{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:46:12Z","timestamp":1774305972597,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Erectile dysfunction (ED) can stem from various organic and functional causes but is often linked to vascular health and cardiovascular disease. Limited data exist on how cardiovascular disease markers correlate with objective ED tests like the Nocturnal Penile Tumescence and Rigidity (NPTR) test and Penile Color Doppler Ultrasound (PCDU). Methods: A prospective observational study was performed, and 58 men with ED were assessed using the International Index of Erectile Function-15 (IIEF-15), NPTR test, and PCDU. Peripheral vascular health was evaluated through carotid intima-media thickness (cIMT) and brachial flow-mediated dilation (FMD). Results: Out of the participants, 44 had normal NPTR results, while 14 had abnormal results. The group with abnormal NPTR results was significantly older and had higher rates of hypertension and diabetes. Although the IIEF-15 scores were similar between the two groups, those with abnormal NPTR results had a lower peak systolic velocity (PSV) and a higher prevalence of impaired PSV. Correlations between the IIEF, NPTR, PCDU, and peripheral vascular markers lost significance after the age adjustment. Conclusions: This study suggests that abnormal NPTR results, combined with cardiovascular risk factors, may signal vascular ED and generalized vasculopathy, highlighting the need for cardiovascular assessment. An accurate ED diagnosis should integrate clinical evaluation with multiple tests while considering aging as a key risk factor.<\/jats:p>","DOI":"10.3390\/jcm13216321","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T04:28:43Z","timestamp":1729657723000},"page":"6321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Study of the Relationship Between Objective Tests to Diagnose Erectile Dysfunction and Markers of Cardiovascular Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0821-3591","authenticated-orcid":false,"given":"Maurizio","family":"De Rocco Ponce","sequence":"first","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Quintian Schwieters","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Meziere","sequence":"additional","affiliation":[{"name":"San Luigi Gonzaga University Hospital, 10043 Orbassano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-3309","authenticated-orcid":false,"given":"Josvany","family":"Sanchez Curbelo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillem","family":"Abad Carratal\u00e1","sequence":"additional","affiliation":[{"name":"Hospital Provincial Castell\u00f3n de la Plana, 12002 Castell\u00f3n de la Plana, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eden","family":"Troka","sequence":"additional","affiliation":[{"name":"Facolt\u00e0 di Medicina e Chirurgia, University of Padua, 35127 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluis","family":"Bassas Arnau","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Ruiz Casta\u00f1\u00e9","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Martinez Barcina","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-9206","authenticated-orcid":false,"given":"Osvaldo","family":"Rajmil","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Puigvert, Instituto de Investigaciones Biom\u00e9dicas Sant Pau (IIB-Sant Pau), Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0022-5347(01)62045-7","article-title":"The epidemiology and pathophysiology of erectile dysfunction","volume":"161","author":"Melman","year":"1999","journal-title":"J. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0002-9343(86)90635-2","article-title":"Impotence","volume":"80","author":"Morley","year":"1986","journal-title":"Am. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/CIRCOUTCOMES.112.966903","article-title":"Prediction of cardiovascular events and all-cause mortality with erectile dysfunction a systematic review and meta-analysis of cohort studies","volume":"6","author":"Vlachopoulos","year":"2013","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1001\/jama.294.23.2996","article-title":"Erectile Dysfunction and Subsequent Cardiovascular Disease","volume":"294","author":"Thompson","year":"2005","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1185\/030079904125003467","article-title":"The multinational Men\u2019s Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population","volume":"20","author":"Rosen","year":"2004","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_6","first-page":"4","article-title":"Impotence and Infertility","volume":"Volume 1","author":"Vaughan","year":"1999","journal-title":"Atlas of Clinical Urology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/andr.12561","article-title":"Penile doppler ultrasound predicts cardiovascular events in men with erectile dysfunction","volume":"7","author":"Caretta","year":"2019","journal-title":"Andrology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/j.1742-1241.2007.01629.x","article-title":"The temporal relationship between erectile dysfunction and cardiovascular disease","volume":"61","author":"Hodges","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"ref_9","first-page":"775","article-title":"Use of nocturnal penile tumescence and rigidity in the evaluation of male erectile dysfunction","volume":"22","author":"Levine","year":"1995","journal-title":"Urol. Clin. North Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/j.1743-6109.2007.00546.x","article-title":"The role of penile color-duplex ultrasound for the evaluation of erectile dysfunction","volume":"4","author":"Aversa","year":"2007","journal-title":"J. Sex. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.sxmr.2018.10.005","article-title":"The Role of Nocturnal Penile Tumescence and Rigidity (NPTR) Monitoring in the Diagnosis of Psychogenic Erectile Dysfunction: A Review","volume":"7","author":"Zou","year":"2019","journal-title":"Sex. Med. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0022-5347(17)36966-5","article-title":"The American Urological Association Symptom Index for Benign Prostatic Hyperplasia","volume":"148","author":"Barry","year":"1992","journal-title":"J. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0090-4295(99)00099-0","article-title":"Diagnostic evaluation of the erectil function domain of the international index of erectile function","volume":"54","author":"Cappelleri","year":"1999","journal-title":"Urology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0022-5347(01)63197-5","article-title":"Nocturnal Penile Tumescence and Rigidity Monitoring in Young Potent Volunteers: Reproducibility, Evaluation Criteria and the Effect of Sexual Intercourse","volume":"159","author":"Hatzichristou","year":"1998","journal-title":"J. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.ijir.3901413","article-title":"Age-matched cavernous peak systolic velocity: A highly sensitive parameter in the diagnosis of arteriogenic erectile dysfunction","volume":"18","author":"Caretta","year":"2006","journal-title":"Int. J. Impot. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.ijir.3901477","article-title":"Doppler evaluation of erectile dysfunction\u2014Part 1","volume":"19","author":"Golijanin","year":"2007","journal-title":"Int. J. Impot. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.ijir.3901478","article-title":"Doppler evaluation of erectile dysfunction\u2014Part 2","volume":"19","author":"Golijanin","year":"2007","journal-title":"Int. J. Impot. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liu, D., Du, C., Shao, W., and Ma, G. (2020). Diagnostic role of carotid intima-media thickness for coronary artery disease: A meta-analysis. Biomed. Res. Int., 2020.","DOI":"10.1155\/2020\/9879463"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/cvr\/cvac095","article-title":"Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health","volume":"119","author":"Heiss","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.atherosclerosis.2007.08.006","article-title":"Asymmetric development of peripheral atherosclerosis in patients with erectile dysfunction: An ultrasonographic study","volume":"197","author":"Foresta","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, G., Zhang, Y., Wu, X., Zhang, W., Jiang, H., and Zhang, X. (2024). Association between the atherogenic index of plasma and erectile dysfunction in US men: A population-based cross-sectional study. Int. J. Impot. Res., ahead of print.","DOI":"10.1038\/s41443-024-00972-w"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/iju.15516","article-title":"The role of lipidic balance on erectile dysfunction in prostate cancer patients undergoing robotic surgery","volume":"31","author":"Fraia","year":"2024","journal-title":"Int. J. Urol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S0090-4295(96)00317-2","article-title":"Comparison of results of nocturnal penile tumescence and rigidity in a sleep laboratory versus a portable home monitor","volume":"48","author":"Guay","year":"1996","journal-title":"Urology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0090-4295(82)90526-X","article-title":"Diagnostic significance of penile erections during sleep","volume":"20","author":"Marshall","year":"1982","journal-title":"Urology"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Gu, Y., Wu, C., Qin, F., and Yuan, J. (2022). Erectile Dysfunction and Obstructive Sleep Apnea: A Review. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.766639"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","article-title":"Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement from the American Heart Association","volume":"144","author":"Yeghiazarians","year":"2021","journal-title":"Circulation."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.eururo.2006.01.028","article-title":"EAU Guidelines on Erectile Dysfunction: An Update","volume":"49","author":"Wespes","year":"2006","journal-title":"Eur. Urol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1111\/j.1743-6109.2009.01343.x","article-title":"Use and abuse of rigiscan in the diagnosis of erectile dysfunction","volume":"6","author":"Jannini","year":"2009","journal-title":"J. Sex. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.urology.2004.03.016","article-title":"Screening for ischemic heart disease in patients with erectile dysfunction: Role of penile Doppler ultrasonography","volume":"64","author":"Morsy","year":"2004","journal-title":"Urology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.ijir.3900642","article-title":"Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients","volume":"13","author":"Kawanishi","year":"2001","journal-title":"Int. J. Impot. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/cvr\/cvaa085","article-title":"Endothelial function in cardiovascular precision medicine: A position paper on behalf of the European Society for Cardiology","volume":"117","author":"Alexander","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/eurheartj\/ehz350","article-title":"Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans","volume":"40","author":"Thijssen","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/HJH.0b013e328353f222","article-title":"Assessment of flow-mediated dilation reproducibility: A nationwide multicenter study","volume":"30","author":"Ghiadoni","year":"2012","journal-title":"J. Hypertens."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0735-1097(02)01976-9","article-title":"Prognostic Role of Reversible Endothelial Dysfunction in Hypertensive Postmenopausal Women","volume":"40","author":"Modena","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1557988306298006","article-title":"Epidemiology of male sexual dysfunction","volume":"1","author":"Hatzimouratidis","year":"2007","journal-title":"Am. J. Mens. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100347","DOI":"10.1016\/j.esxm.2021.100347","article-title":"Association Between Penile Color Doppler Ultrasonography and Cardiorespiratory Fitness in Patients With Vascular Erectile Dysfunction","volume":"9","author":"Vecchiato","year":"2021","journal-title":"Sex. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12610-023-00206-x","article-title":"Association between sleep quality and nocturnal erection monitor by RigiScan in erectile dysfunction patients: A prospective study using fitbit charge 2","volume":"33","author":"Zhang","year":"2023","journal-title":"Basic. Clin. Androl."},{"key":"ref_40","first-page":"904141","article-title":"Evaluation of the endoPAT as a tool to assess endothelial function","volume":"2012","author":"Moerland","year":"2012","journal-title":"Int. J. Vasc. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/21\/6321\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:18:16Z","timestamp":1760113096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/21\/6321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":40,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["jcm13216321"],"URL":"https:\/\/doi.org\/10.3390\/jcm13216321","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]}}}