{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:13:18Z","timestamp":1787065998780,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-15-2022-310"],"award-info":[{"award-number":["075-15-2022-310"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The rarity and variability of MEN1-related primary hyperparathyroidism (mPHPT) has led to contradictory data regarding the bone phenotype in this patient population. Methods: A single-center retrospective study was conducted among young age- and sex-matched patients with mPHPT and sporadic hyperparathyroidism (sPHPT). The main parameters of calcium\u2013phosphorus metabolism, bone remodeling markers, and bone mineral density (BMD) measurements were obtained during the active phase of hyperparathyroidism before parathyroidectomy (PTE) and 1 year after. Trabecular Bone Score (TBS) and 3D-DXA analysis of the proximal femur were used to evaluate the differences in bone architecture disruption between groups. Results: Patients with mPHPT had significant lower preoperative BMD compared to sPHPT at lumbar spine\u2014LS (p = 0.002); femur neck\u2014FN (p = 0.001); and total hip\u2014TH (p = 0.002). 3D-DXA analysis showed the prevalence of cortical rather than trabecular bone damage in mPHPT compared to sPHPT: cortical thickness (p &lt; 0.001); cortical surface BMD (p = 0.001); cortical volumetric BMD (p = 0.007); and trabecular volumetric BMD (p = 0.029). One year after, PTE DXA and 3D-DXA parameters were similar between groups, while 3D-visualisation showed more extensive regeneration in cortical sBMD and cortical thickness in mPHPT. Conclusions: mPHPT is associated with lower preoperative BMD values with predominant architecture disruption in the cortical bone. The absence of differences in DXA and 3D-DXA parameters 1 year after PTE between mPHPT\/sPHPT combined with significantly lower BMD in mPHPT at the initial stage may indicate faster bone recovery after surgery in mPHPT than in sPHPT.<\/jats:p>","DOI":"10.3390\/jcm13216382","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:42:13Z","timestamp":1729845733000},"page":"6382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Bone Phenotype Differences in MEN1-Related and Sporadic Primary Hyperparathyroidism Using 3D-DXA"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-062X","authenticated-orcid":false,"given":"Anna K.","family":"Eremkina","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-2143","authenticated-orcid":false,"given":"Svetlana V.","family":"Pylina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina R.","family":"Elfimova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-9457","authenticated-orcid":false,"given":"Anna M.","family":"Gorbacheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Humbert","sequence":"additional","affiliation":[{"name":"3D-Shaper Medical, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-6704","authenticated-orcid":false,"given":"Mirella","family":"L\u00f3pez Picazo","sequence":"additional","affiliation":[{"name":"3D-Shaper Medical, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina V.","family":"Hajrieva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-9016","authenticated-orcid":false,"given":"Ekaterina N.","family":"Solodovnikova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya D.","family":"Kovalevich","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Vetchinkina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-2297","authenticated-orcid":false,"given":"Ekaterina V.","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Tarbaeva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia G.","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/endrev\/bnaa031","article-title":"Multiple endocrine neoplasia type 1: Latest insights","volume":"42","author":"Brandi","year":"2021","journal-title":"Endocr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41574-021-00468-3","article-title":"Clinical aspects of multiple endocrine neoplasia type 1","volume":"17","author":"Cadiot","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1210\/jc.2014-3659","article-title":"Men1 disease occurring before 21 years old: A 160-patient cohort study from the groupe d\u2019etude des tumeurs endocrines","volume":"100","author":"Goudet","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (men1)","volume":"97","author":"Thakker","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1750-1172-8-50","article-title":"Differences between sporadic and men related primary hyperparathyroidism; clinical expression, preoperative workup, operative strategy and follow-up","volume":"8","author":"Twigt","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/jbmr.125","article-title":"Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1-associated primary hyperparathyroidism","volume":"25","author":"Lourenco","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1359\/jbmr.090304","article-title":"Sporadic and men1-related primary hyperparathyroidism: Differences in clinical expression and severity","volume":"24","author":"Chiodini","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/cen.14945","article-title":"Clinical profile and treatment outcomes among patients with sporadic and multiple endocrine neoplasia syndrome-related primary hyperparathyroidism","volume":"99","author":"Mathew","year":"2023","journal-title":"Clin. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.surg.2016.06.065","article-title":"Operative intervention for primary hyperparathyroidism offers greater bone recovery in patients with sporadic disease than in those with multiple endocrine neoplasia type 1-related hyperparathyroidism","volume":"161","author":"Silva","year":"2017","journal-title":"Surgery"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1530\/EJE-08-0153","article-title":"Multiple endocrine neoplasia type 1 in brazil: Men1 founding mutation, clinical features, and bone mineral density profile","volume":"159","author":"Lourenco","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"ref_11","first-page":"573","article-title":"Peripheral bone mineral density in correlation to disease-related predisposing conditions in patients with multiple endocrine neoplasia type 1","volume":"35","author":"Kann","year":"2012","journal-title":"J. Endocrinol. Invest."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Altieri, B., Di Dato, C., Modica, R., Bottiglieri, F., Di Sarno, A., Pittaway, J.F.H., Martini, C., Faggiano, A., and Colao, A. (2020). Bone metabolism and vitamin d implication in gastroenteropancreatic neuroendocrine tumors. Nutrients, 12.","DOI":"10.3390\/nu12041021"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/humu.22981","article-title":"Hgvs recommendations for the description of sequence variants: 2016 update","volume":"37","author":"Dalgleish","year":"2016","journal-title":"Hum. Mutat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1254806","DOI":"10.1126\/science.1254806","article-title":"Rna splicing. The human splicing code reveals new insights into the genetic determinants of disease","volume":"347","author":"Xiong","year":"2015","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/hmg\/6.7.1169","article-title":"Germline mutations of the men1 gene in familial multiple endocrine neoplasia type 1 and related states","volume":"6","author":"Agarwal","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e26382","DOI":"10.1097\/MD.0000000000026382","article-title":"A germline c.1546dupc men1 mutation in an men1 family: A case report","volume":"100","author":"Cho","year":"2021","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1097\/SLA.0b013e31824c5145","article-title":"Primary hyperparathyroidism in men1 patients: A cohort study with longterm follow-up on preferred surgical procedure and the relation with genotype","volume":"255","author":"Pieterman","year":"2012","journal-title":"Ann. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1590\/S0004-27302010000800007","article-title":"Application of genetic testing to define the surgical approach in a sporadic case of multiple endocrine neoplasia type 1","volume":"54","author":"Boguszewski","year":"2010","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E282","DOI":"10.1210\/jc.2011-0241","article-title":"Menin missense mutants encoded by the men1 gene that are targeted to the proteasome: Restoration of expression and activity by chip sirna","volume":"97","author":"Canaff","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.14341\/probl12864","article-title":"Severe bone complications of primary hyperparathyroidism in a young patient with the rare verified mutation of men1","volume":"68","author":"Eremkina","year":"2022","journal-title":"Probl. Endokrinol. (Mosk)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12020-018-1566-8","article-title":"Multiple endocrine neoplasia type 1: Analysis of germline men1 mutations in the italian multicenter men1 patient database","volume":"62","author":"Marini","year":"2018","journal-title":"Endocrine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1530\/EC-17-0126","article-title":"Primary hyperparathyroidism in young patients in russia: High frequency of hyperparathyroidism-jaw tumor syndrome","volume":"6","author":"Mamedova","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1055\/a-1147-1375","article-title":"Identification of novel variants in men1: A study conducted with four multiple endocrine neoplasia type 1 patients","volume":"52","author":"Hu","year":"2020","journal-title":"Horm. Metab. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1507\/endocrj.K08E-265","article-title":"Men1 gene analysis in patients with primary hyperparathyroidism: 10-year experience of a single institution for thyroid and parathyroid care in japan","volume":"56","author":"Kihara","year":"2009","journal-title":"Endocr. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1530\/EJE-13-1008","article-title":"Insulinoma in childhood: Clinical, radiological, molecular and histological aspects of nine patients","volume":"170","author":"Padidela","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"16033","DOI":"10.1038\/nrdp.2016.33","article-title":"Primary hyperparathyroidism","volume":"2","author":"Bilezikian","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"bvaa077","DOI":"10.1210\/jendso\/bvaa077","article-title":"Unusual combination of men-1 and the contiguous gene deletion syndrome of cah and ehlers-danlos syndrome (cah-x)","volume":"4","author":"Jarad","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/humu.23337","article-title":"Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma","volume":"38","author":"Cardoso","year":"2017","journal-title":"Hum. Mutat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2169\/internalmedicine.51.7475","article-title":"A puzzling case of phospho-soda-induced hypocalcemia in a patient with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism","volume":"51","author":"Ozveren","year":"2012","journal-title":"Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<373::AID-IJC7>3.0.CO;2-B","article-title":"Men1 gene mutation analysis of sporadic adrenocortical lesions","volume":"80","author":"Roth","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Klementieva, N., Goliusova, D., Krupinova, J., Yanvarev, V., Panova, A., Mokrysheva, N., and Kiselev, S.L. (2021). A novel isogenic human cell-based system for men1 syndrome generated by crispr\/cas9 genome editing. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222112054"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/humu.23746","article-title":"Proposition of adjustments to the acmg-amp framework for the interpretation of men1 missense variants","volume":"40","author":"Romanet","year":"2019","journal-title":"Hum. Mutat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.3892\/mmr.2017.7749","article-title":"Analysis of men1 c.482g>a (p.Gly161asp) mutation in a pedigree with familial multiple endocrine neoplasia type 1","volume":"16","author":"Luo","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-1004(1999)13:3<175::AID-HUMU1>3.0.CO;2-R","article-title":"Germline mutations in the multiple endocrine neoplasia type 1 gene: Evidence for frequent splicing defects","volume":"13","author":"Mutch","year":"1999","journal-title":"Hum. Mutat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/jmg.2003.017319","article-title":"A report of a national mutation testing service for the men1 gene: Clinical presentations and implications for mutation testing","volume":"42","author":"Cardinal","year":"2005","journal-title":"J. Med. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1098-1004(1999)13:1<54::AID-HUMU6>3.0.CO;2-K","article-title":"Mutation analysis of the men1 gene in belgian patients with multiple endocrine neoplasia type 1 and related diseases","volume":"13","author":"Poncin","year":"1999","journal-title":"Hum. Mutat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/01.GIM.0000153663.62300.F8","article-title":"Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory","volume":"7","author":"Klein","year":"2005","journal-title":"Genet. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13023-020-01380-1","article-title":"Bone tissue and mineral metabolism in hereditary endocrine tumors: Clinical manifestations and genetic bases","volume":"15","author":"Maraghelli","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mokrysheva, N.G., Eremkina, A.K., Elfimova, A.R., Kovaleva, E.V., Miliutina, A.P., Bibik, E.E., Gorbacheva, A.M., Dobreva, E.A., Maganeva, I.S., and Krupinova, J.A. (2023). The russian registry of primary hyperparathyroidism, latest update. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1203437"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kong, J., Wang, O., Nie, M., Shi, J., Hu, Y., Jiang, Y., Li, M., Xia, W., Meng, X., and Xing, X. (2016). Clinical and genetic analysis of multiple endocrine neoplasia type 1-related primary hyperparathyroidism in chinese. PLoS ONE, 11.","DOI":"10.1530\/boneabs.5.P445"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.6061\/clinics\/2012(Sup01)17","article-title":"Biochemical, bone and renal patterns in hyperparathyroidism associated with multiple endocrine neoplasia type 1","volume":"67","author":"Lourenco","year":"2012","journal-title":"Clinics"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Marini, F., Giusti, F., Cioppi, F., Maraghelli, D., Cavalli, T., Tonelli, F., and Brandi, M.L. (2021). Bone and mineral metabolism phenotypes in men1-related and sporadic primary hyperparathyroidism, before and after parathyroidectomy. Cells, 10.","DOI":"10.3390\/cells10081895"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.metabol.2017.10.003","article-title":"Bone disease in primary hyperparathyroidism","volume":"80","author":"Makras","year":"2018","journal-title":"Metabolism"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bone.2013.03.009","article-title":"New insights into the effects of primary hyperparathyroidism on the cortical and trabecular compartments of bone","volume":"55","author":"Vu","year":"2013","journal-title":"Bone"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00198-019-05186-1","article-title":"Impaired geometry, volumetric density, and microstructure of cortical and trabecular bone assessed by hr-pqct in both sporadic and men1-related primary hyperparathyroidism","volume":"31","author":"Wang","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/clinem\/dgad460","article-title":"Trabecular bone score as a more sensitive tool to evaluate bone involvement in men1-related primary hyperparathyroidism","volume":"109","author":"Song","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/archsurg.134.10.1119","article-title":"Osteoporosis in multiple endocrine neoplasia type 1: Severity, clinical significance, relationship to primary hyperparathyroidism, and response to parathyroidectomy","volume":"134","author":"Burgess","year":"1999","journal-title":"Arch. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2265.2009.03672.x","article-title":"Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy","volume":"72","author":"Coutinho","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e210494","DOI":"10.1530\/EC-21-0494","article-title":"The role of menin in bone pathology","volume":"11","author":"Gorbacheva","year":"2022","journal-title":"Endocr. Connect."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/21\/6382\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:20:02Z","timestamp":1760113202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/21\/6382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":50,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["jcm13216382"],"URL":"https:\/\/doi.org\/10.3390\/jcm13216382","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}