{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:33:53Z","timestamp":1760146433037,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","doi-asserted-by":"publisher","award":["JP20K18288"],"award-info":[{"award-number":["JP20K18288"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Wideband tympanometry (WBT) has the potential to distinguish various mechanical middle ear and inner ear pathologies noninvasively. This study investigated the diagnostic value of WBT in the diagnosis of enlarged vestibular aqueduct (EVA). Methods: The absorbance and resonance frequency (RF) of patients with EVA (40 ears, 25 patients) and matched population controls (39 ears, 28 subjects) were compared, alongside receiver operating characteristic (ROC) analysis. Correlations between VA width and RF were also examined. Results: Patients with EVA had higher absorbance at low frequencies (226\u2013917 Hz) and lower absorbance at high frequencies (2520\u20134896 Hz) compared to controls. The RF of the EVA group was significantly lower versus controls (751 [391\u20131165] vs. 933 [628\u20131346] Hz). The ROC analysis revealed area under the curve values of 0.771 and 0.801, respectively, for absorbance and RF. RF had a sensitivity, specificity, positive predictive value, and negative predictive value of 74.4%, 82.5%, 76.7%, and 80.6%, respectively, for diagnosing EVA. In the EVA group, the VA midpoint width (r = \u22120.334) and VA petrous width (r = \u22120.402) both significantly correlated with RF. Conclusions: Our findings support the utility of WBT for diagnosing EVA, with RF as the optimal index used.<\/jats:p>","DOI":"10.3390\/jcm13216602","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T10:57:20Z","timestamp":1730717840000},"page":"6602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of Enlarged Vestibular Aqueduct Using Wideband Tympanometry"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-8886","authenticated-orcid":false,"given":"Akira","family":"Ganaha","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, International University of Health and Welfare, Narita Hospital, Narita 286-8520, Japan"},{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University of the Ryukyus, Nishihara 903-0215, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, International University of Health and Welfare, Narita Hospital, Narita 286-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2317-7450","authenticated-orcid":false,"given":"Takeshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"Higa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University of the Ryukyus, Nishihara 903-0215, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University of the Ryukyus, Nishihara 903-0215, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tono","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, International University of Health and Welfare, Tochigi 324-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00206099109072866","article-title":"Developmental changes in multifrequency tympanograms","volume":"30","author":"Holte","year":"1991","journal-title":"Audiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3766\/jaaa.25.5.6","article-title":"Wideband absorbance in young infants (0\u20136 months): A cross-sectional study","volume":"25","author":"Aithal","year":"2014","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/00206098509070096","article-title":"Multifrequency tympanometry in normal ears","volume":"24","author":"Margolis","year":"1985","journal-title":"Audiology."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.21053\/ceo.2018.01137","article-title":"Can wideband tympanometry be used as a screening test for superior semicircular canal dehiscence?","volume":"12","author":"Demir","year":"2019","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0196-0709(83)80071-4","article-title":"Transmission of cerebrospinal fluid pressure via the cochlear aqueduct and endolymphatic sac","volume":"4","author":"Carlborg","year":"1983","journal-title":"Am. J. Otolaryngol."},{"key":"ref_6","first-page":"703","article-title":"Effect of increased inner ear pressure on middle ear mechanics","volume":"118","author":"Murakami","year":"1998","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1044\/jshr.1502.330","article-title":"Effects of body position on the auditory system","volume":"15","author":"Macrae","year":"1972","journal-title":"J. Speech Hear. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.anl.2017.05.008","article-title":"Diagnosis and following up of M\u00e9ni\u00e8re\u2019s disease using multifrequency tympanometry-Cutoff values and temporal changes in measurements","volume":"45","author":"Ishizu","year":"2018","journal-title":"Auris Nasus Larynx"},{"key":"ref_9","first-page":"671","article-title":"Air-bone gap and resonant frequency in large vestibular aqueduct syndrome","volume":"21","author":"Nakashima","year":"2000","journal-title":"Am. J. Otol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5152\/JIAO.2021.8632","article-title":"The third mobile window effects in otology\/ neurotology","volume":"17","author":"Ota","year":"2021","journal-title":"J. Int. Adv. Otol."},{"key":"ref_11","first-page":"387","article-title":"The large vestibular aqueduct syndrome","volume":"6","author":"Emmett","year":"1985","journal-title":"Am. J. Otol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-5876(99)00268-2","article-title":"Audiological findings in large vestibular aqueduct syndrome","volume":"51","author":"Govaerts","year":"1999","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/14992020500057665","article-title":"Hearing loss in patients with enlarged vestibular aqueduct: Air-bone gap and audiological Bing test","volume":"44","author":"Mimura","year":"2005","journal-title":"Int. J. Audiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/cge.12074","article-title":"SLC26A4 mutation frequency and spectrum in 109 Danish Pendred syndrome\/DFNB4 probands and a report of nine novel mutations","volume":"84","author":"Rendtorff","year":"2013","journal-title":"Clin. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/lio2.988","article-title":"Three-dimensional wideband absorbance immittance findings in young adults with large vestibular aqueduct syndrome","volume":"8","author":"Zhang","year":"2023","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Li, A., Du, H., Gao, J., Xu, Y., Zhao, N., Gao, S., Xing, Y., Qian, X., Gao, X., and Yang, Y. (2023). Characteristics of large vestibular aqueduct syndrome in wideband acoustic immittance. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1185033"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archotol.1972.00770090791004","article-title":"Studies in impedance audiometry. I. Normal and sensorineural ears","volume":"96","author":"Jerger","year":"1972","journal-title":"Arch. Otolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/lary.1978.88.5.723","article-title":"The large vestibular aqueduct syndrome","volume":"88","author":"Valvassori","year":"1978","journal-title":"Laryngoscope"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3174\/ajnr.A0495","article-title":"When is the vestibular aqueduct enlarged? A statistical analysis of the normative distribution of vestibular aqueduct size","volume":"28","author":"Vijayasekaran","year":"2007","journal-title":"Am. J. Neuroradiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/lary.25664","article-title":"Correlation of vestibular aqueduct size with air-bone gap in enlarged vestibular aqueduct syndrome","volume":"126","author":"Seo","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_21","unstructured":"Hunter, L.L., and Shahnaz, N. (2014). Acoustic Immittance Measures: Basic and Advanced Practice, Plural Publishing."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/000348946907800105","article-title":"Pneumatization of the temporal bone","volume":"78","author":"Allam","year":"1969","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1017\/S0022215100054049","article-title":"Pneumatization of the mastoid bone","volume":"72","author":"Diamant","year":"1958","journal-title":"J. Laryngol. Otol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/archotol.124.3.249","article-title":"Sound- and\/or pressure-induced vertigo due to bone dehiscence of the superior semicircular canal","volume":"124","author":"Minor","year":"1998","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/000348946207100101","article-title":"Closure of the cochlear windows: Its effect upon air- and bone-conduction","volume":"71","author":"Tonndorf","year":"1962","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-5955(97)00017-8","article-title":"Anatomy of the normal human cochlear aqueduct with functional implications","volume":"107","author":"Gopen","year":"1997","journal-title":"Hear. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/archotol.1989.01860250056026","article-title":"The large vestibular aqueduct syndrome in children. A review of 12 cases and the description of a new clinical entity","volume":"115","author":"Levenson","year":"1989","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/MAO.0b013e318161ab24","article-title":"Conductive hearing loss caused by third-window lesions of the inner ear","volume":"29","author":"Merchant","year":"2008","journal-title":"Otol. Neurotol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"48S","DOI":"10.1097\/AUD.0b013e31829c964d","article-title":"Assessment of ear disorders using power reflectance","volume":"34","author":"Nakajima","year":"2013","journal-title":"Ear Hear."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1097\/AUD.0b013e31829d5a14","article-title":"An overview of wideband immittance measurements techniques and terminology: You say absorbance, I say reflectance","volume":"34","author":"Rosowski","year":"2013","journal-title":"Ear Hear."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/00016489.2020.1754460","article-title":"Effects of endolymphatic hydrops on acoustic energy absorbance","volume":"140","author":"Kobayashi","year":"2020","journal-title":"Acta Otolaryngol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/lary.25747","article-title":"Endolymphatic hydrops in superior canal dehiscence and large vestibular aqueduct syndromes","volume":"126","author":"Sone","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1097\/00005537-200209000-00021","article-title":"Tympanometric findings in patients with enlarged vestibular aqueducts","volume":"112","author":"Sato","year":"2002","journal-title":"Laryngoscope"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"111034","DOI":"10.1016\/j.ijporl.2021.111034","article-title":"Inter-rater reliability of the diagnosis of otitis media based on otoscopic images and wideband tympanometry measurements","volume":"153","author":"Sundgaard","year":"2022","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1179\/1754762815Y.0000000016","article-title":"Histopathology of inner ear malformations: Do we have enough evidence to explain pathophysiology?","volume":"17","author":"Sennaroglu","year":"2016","journal-title":"Cochlear Implants Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.anl.2008.07.002","article-title":"Middle ear impedance measurements in large vestibular aqueduct syndrome","volume":"36","author":"Bilgen","year":"2009","journal-title":"Auris Nasus Larynx"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1288\/00005537-198912000-00006","article-title":"The large vestibular aqueduct syndrome","volume":"99","author":"Jackler","year":"1989","journal-title":"Laryngoscope"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.amjoto.2005.02.013","article-title":"Large vestibular aqueduct syndrome: Audiological, radiological, clinical, and genetic features","volume":"26","author":"Berrettini","year":"2005","journal-title":"Am. J. Otolaryngol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ideura, M., Nishio, S.Y., Moteki, H., Takumi, Y., Miyagawa, M., Sato, T., Kobayashi, Y., Ohyama, K., Oda, K., and Matsui, T. (2019). Comprehensive analysis of syndromic hearing loss patients in Japan. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-47141-4"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1002\/lary.30605","article-title":"Newborn hearing screening results in patients with enlarged vestibular aqueduct","volume":"133","author":"Perry","year":"2023","journal-title":"Laryngoscope"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ald\u00e8, M., Cantarella, G., Zanetti, D., Pignataro, L., La Mantia, I., Maiolino, L., Ferlito, S., Di Mauro, P., Cocuzza, S., and Lechien, J.R. (2023). Autosomal dominant non-syndromic hearing loss (DFNA): A comprehensive narrative review. Biomedicines., 11.","DOI":"10.3390\/biomedicines11061616"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"27S","DOI":"10.1097\/AUD.0b013e31829d5328","article-title":"Wideband acoustic immittance normative data: Ethnicity, gender, aging, and instrumentation","volume":"34","author":"Shahnaz","year":"2013","journal-title":"Ear Hear."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/21\/6602\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:27:39Z","timestamp":1760113659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/21\/6602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,3]]},"references-count":42,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["jcm13216602"],"URL":"https:\/\/doi.org\/10.3390\/jcm13216602","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,11,3]]}}}