{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T23:13:34Z","timestamp":1776035614470,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy","award":["1685\/26.01.2024"],"award-info":[{"award-number":["1685\/26.01.2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Status asthmaticus is a severe, life-threatening asthma exacerbation requiring urgent medical intervention. This study aims to examine its epidemiology in Timis County, Romania, over 11 years. Methods: A retrospective analysis was conducted using hospital records from 2013 to 2023, focusing on demographic, geospatial, and temporal distributions. Network analysis of the recorded comorbidities was used to identify phenotypic clusters among patients. Results: Females and older adults were disproportionately affected. Several triggers and geospatial patterns were identified. Five phenotypic clusters were determined: two in the T2-high endotype, two in T2-low, and a mixed one. Conclusions: The findings highlight the need for personalized asthma management strategies and public healthcare interventions in Timi\u0219 County, addressing specific demographic and geospatial factors. This study also provides a valuable reference for similar regions.<\/jats:p>","DOI":"10.3390\/jcm13216615","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T10:57:20Z","timestamp":1730717840000},"page":"6615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Multifaceted Exploration of Status Asthmaticus: A Retrospective Analysis in a Romanian Hospital"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5270-1464","authenticated-orcid":false,"given":"Adriana Ana","family":"Trusculescu","sequence":"first","affiliation":[{"name":"Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania"},{"name":"Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babe\u0219 Timi\u0219oara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4840-1925","authenticated-orcid":false,"given":"Versavia Maria","family":"Ancusa","sequence":"additional","affiliation":[{"name":"Department of Computer and Information Technology, Automation and Computers Faculty, \u201cPolitehnica\u201d University of Timis, Vasile P\u00e2rvan Blvd, no. 2, 300223 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-3714","authenticated-orcid":false,"given":"Camelia Corina","family":"Pescaru","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania"},{"name":"Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babe\u0219 Timi\u0219oara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0749-8232","authenticated-orcid":false,"given":"Norbert","family":"Wellmann","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania"},{"name":"Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babe\u0219 Timi\u0219oara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corneluta","family":"Fira-Mladinescu","sequence":"additional","affiliation":[{"name":"Hygiene Division, Department of Microbiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Victor Babes Street, no. 16, 300226 Timisoara, Romania"},{"name":"Center for Study in Preventive Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-0581","authenticated-orcid":false,"given":"Cristian Iulian","family":"Oancea","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania"},{"name":"Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babe\u0219 Timi\u0219oara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9034-5218","authenticated-orcid":false,"given":"Ovidiu","family":"Fira-Mladinescu","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania"},{"name":"Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babe\u0219 Timi\u0219oara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Vos","year":"2020","journal-title":"Lancet"},{"key":"ref_2","unstructured":"Chakraborty, R.K., Chen, R.J., and Basnet, S. 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