{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:17Z","timestamp":1760146457182,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Data-Driven Health Division of National Laboratory for Health Security","award":["RRF-2.3.1-21-2022-00006","K128780","VEKOP-2.3.3-15-2016-00006"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00006","K128780","VEKOP-2.3.3-15-2016-00006"]}]},{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00006","K128780","VEKOP-2.3.3-15-2016-00006"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00006","K128780","VEKOP-2.3.3-15-2016-00006"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian Ministry of National Economy","award":["RRF-2.3.1-21-2022-00006","K128780","VEKOP-2.3.3-15-2016-00006"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00006","K128780","VEKOP-2.3.3-15-2016-00006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: The aim of this matched prospective cohort study was to examine the microarchitecture of the augmented bone following a modified alveolar ridge splitting procedure and compare it to that of native bone. Methods: In the test group, patients underwent a modified ridge split osteotomy procedure to restore the width of the posterior segment of the mandible. Patients with sufficient bone width for dental implant placement in the posterior region of the mandible following 3-month-long spontaneous healing after tooth removal were included in the control group. In both study groups, bone biopsy samples were harvested and dental implants were placed. Histomorphometry and micro-CT analysis were performed. Results: Altogether, 15 patients were included in this study (7 patients in the test group, with 14 bone core biopsies harvested, and 8 patients in the control group, with 13 bone core biopsies harvested). Percentage bone volume (BV\/TV) in the micro-CT analysis (22.088 \u00b1 8.094% and 12.075 \u00b1 4.009% for the test and control group, respectively) showed statistically significant differences between study groups. Conclusions: Based on histological and micro-CT analyses, the modified ridge splitting procedure with autologous bone block harvested from the retromolar area results in a dental implant recipient bone microarchitecture superior to that of the extraction sockets left to heal undisturbed for a 3-month-long healing period.<\/jats:p>","DOI":"10.3390\/jcm13226679","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T07:47:16Z","timestamp":1730965636000},"page":"6679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microarchitectural Study of the Augmented Bone Following a Modified Ridge Splitting Technique: Histological and Micro-Computed Tomography Analyses"],"prefix":"10.3390","volume":"13","author":[{"given":"Dorottya","family":"P\u00e9nzes","sequence":"first","affiliation":[{"name":"Department of Public Dental Health, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csilla","family":"Szerencse","sequence":"additional","affiliation":[{"name":"Department of Public Dental Health, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Major","sequence":"additional","affiliation":[{"name":"Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, M\u00e1ria utca 52, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, M\u00e1ria utca 52, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-1392","authenticated-orcid":false,"given":"Endre","family":"Kontsek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic and Insurance Medicine University, \u00dcll\u0151i \u00fat 93, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-3021","authenticated-orcid":false,"given":"J\u00e1nos","family":"B\u00e1skay","sequence":"additional","affiliation":[{"name":"Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre, Semmelweis University, K\u00fatv\u00f6lgyi \u00fat 2, 1125 Budapest, Hungary"},{"name":"Department of Biological Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P\u00e9ter S\u00e9t\u00e1ny 1\/a, 1117 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Pollner","sequence":"additional","affiliation":[{"name":"Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre, Semmelweis University, K\u00fatv\u00f6lgyi \u00fat 2, 1125 Budapest, Hungary"},{"name":"Department of Biological Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P\u00e9ter S\u00e9t\u00e1ny 1\/a, 1117 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5933-3956","authenticated-orcid":false,"given":"Bence Tam\u00e1s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostics, Semmelweis University, Szentkir\u00e1lyi utca 47, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-7926","authenticated-orcid":false,"given":"Csaba","family":"Dob\u00f3-Nagy","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostics, Semmelweis University, Szentkir\u00e1lyi utca 47, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"Csete","sequence":"additional","affiliation":[{"name":"Department of Physiology, Semmelweis University, T\u0171zolt\u00f3 u. 34-37, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0512-1157","authenticated-orcid":false,"given":"Attila","family":"M\u00f3csai","sequence":"additional","affiliation":[{"name":"Department of Physiology, Semmelweis University, T\u0171zolt\u00f3 u. 34-37, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-3885","authenticated-orcid":false,"given":"Nadim Z.","family":"Baba","sequence":"additional","affiliation":[{"name":"Advanced Dental Education Program in Implant Dentistry, School of Dentistry, Loma Linda University, Loma Linda, CA 92350, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Department of Public Dental Health, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-7027","authenticated-orcid":false,"given":"M\u00e1rton","family":"Kivovics","sequence":"additional","affiliation":[{"name":"Department of Public Dental Health, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-7529","authenticated-orcid":false,"given":"Eitan","family":"Mijiritsky","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, School of Medicine, Tel Aviv University, Tel Aviv 64239, Israel"},{"name":"Goldschleger School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 39040, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1708-8208.2004.tb00024.x","article-title":"Implant stability, tissue conditions, and patient self-evaluation after treatment with osseointegrated implants in the posterior mandible","volume":"6","author":"Farzad","year":"2004","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0501.2012.02546.x","article-title":"A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years","volume":"23","author":"Pjetursson","year":"2012","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.4103\/jispcd.JISPCD_149_17","article-title":"Prosthetic Consideration in Implant-supported Prosthesis: A Review of Literature","volume":"7","author":"Gowd","year":"2017","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1902\/jop.2001.72.11.1560","article-title":"Immediate implantation in fresh extraction sockets. A controlled clinical and histological study in man","volume":"72","author":"Paolantonio","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1601-0825.2010.01699.x","article-title":"Atrophy of the residual alveolar ridge following tooth loss in an historical population","volume":"17","author":"Reich","year":"2011","journal-title":"Oral Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/prd.12039","article-title":"Horizontal bone augmentation by means of guided bone regeneration","volume":"66","author":"Benic","year":"2014","journal-title":"Periodontology 2000"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/cid.12438","article-title":"Lateral Ridge Augmentation Using Autogenous Block Grafts and Guided Bone Regeneration: A 10-Year Prospective Case Series Study","volume":"19","author":"Chappuis","year":"2017","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-0501.2006.01301.x","article-title":"Autogenous bone graft alone or associated with titanium mesh for vertical alveolar ridge augmentation: A controlled clinical trial","volume":"18","author":"Roccuzzo","year":"2007","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ren, Y., Fan, L., Alkildani, S., Liu, L., Emmert, S., Najman, S., Rimashevskiy, D., Schnettler, R., Jung, O., and Xiong, X. (2022). Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314987"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tumedei, M., Mour\u00e3o, C.F., D\u2019Agostino, S., Dolci, M., Di Cosola, M., Piattelli, A., and Lucchese, A. (2021). Histological and Histomorphometric Effectiveness of the Barrier Membranes for Jawbone Regeneration: An Overview of More Than 30 Years\u2019 Experience of Research Results of the Italian Implant Retrieval Center (1988\u20132020). Appl. Sci., 11.","DOI":"10.3390\/app11052438"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.5005\/jp-journals-10024-3704","article-title":"Comparison of Khoury\u2019s Bone Shell Technique vs Titanium-reinforced Polytetrafluoroethylene Membrane for 3D-bone Augmentation in Atrophic Posterior Mandible: A Randomized Clinical Trial","volume":"25","author":"Shaker","year":"2024","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"P\u00e9nzes, D., Simon, F., Mijiritsky, E., N\u00e9meth, O., and Kivovics, M. (2020). A Modified Ridge Splitting Technique Using Autogenous Bone Blocks-A Case Series. Materials, 13.","DOI":"10.3390\/ma13184036"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/cid.13363","article-title":"Advancements in dental implantology: The alveolar ridge split technique for enhanced osseointegration","volume":"26","author":"Luo","year":"2024","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_14","first-page":"141","article-title":"Rehabilitation of patients with thin ridges by conical expanders and immediate cone morse dental implant: A case report","volume":"27","author":"Scarano","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.21608\/edj.2022.142588.2152","article-title":"Evaluation of Bone Width Recovery After Using Modified Ridge Splitting Technique With and Without Beta-Tricalcium Phosphate Material (A randomized clinical trial)","volume":"68","author":"Khashaba","year":"2022","journal-title":"Egypt. Dent. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00784-023-05427-y","article-title":"Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: Randomized controlled clinical trial","volume":"28","author":"Issa","year":"2024","journal-title":"Clin. Oral Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1902\/jop.1991.62.1.2","article-title":"The excessive loss of Branemark fixtures in type IV bone: A 5-year analysis","volume":"62","author":"Jaffin","year":"1991","journal-title":"J. Periodontol."},{"key":"ref_18","first-page":"220","article-title":"Evaluation of patient and implant characteristics as potential prognostic factors for oral implant failures","volume":"20","author":"Herrmann","year":"2005","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E065","DOI":"10.5005\/jcdp-11-6-65","article-title":"Success or failure of a dental implant: Its relationship to bone density: A case report of a failed implant","volume":"11","author":"Malik","year":"2010","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jbo.2012.10.003","article-title":"Histomorphometric and microarchitectural analyses using the 2 mm bone marrow trephine in metastatic breast cancer patients-preliminary results","volume":"1","author":"Fralick","year":"2012","journal-title":"J. Bone Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/clr.14210","article-title":"Critical-size defects reconstruction with four different bone grafts associated with e-PTFE membrane: A histomorphometric experimental in vivo study","volume":"35","author":"Fernandes","year":"2024","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-1-0716-1847-9_10","article-title":"Micro-CT-Based Bone Microarchitecture Analysis of the Murine Skull","volume":"2403","author":"Tan","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"335","author":"Altman","year":"2007","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J. Anaesth."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.11607\/jomi.2201","article-title":"Mandibular ridge expansion using a horizontal bone-splitting technique and synthetic bone substitute: An alternative to bone block grafting?","volume":"29","author":"Ella","year":"2014","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"B\u00e1skay, J., P\u00e9nzes, D., Kontsek, E., Pesti, A., Kiss, A., Guimar\u00e3es Carvalho, B.K., Sz\u00f3cska, M., Szab\u00f3, B.T., Dob\u00f3-Nagy, C., and Csete, D. (2024). Are Artificial Intelligence-Assisted Three-Dimensional Histological Reconstructions Reliable for the Assessment of Trabecular Microarchitecture?. J. Clin. Med., 13.","DOI":"10.3390\/jcm13041106"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/clr.13276","article-title":"Implant placement and loading protocols in partially edentulous patients: A systematic review","volume":"29","author":"Gallucci","year":"2018","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gasperini, F.M., Fernandes, G.V.O., Mitri, F.F., Calasans-Maia, M.D., Mavropoulos, E., Malta Rossi, A., and Granjeiro, J.M. (2023). Histomorphometric evaluation, SEM, and synchrotron analysis of the biological response of biodegradable and ceramic hydroxyapatite-based grafts: From the synthesis to the bed application. Biomed. Mater., 18.","DOI":"10.1088\/1748-605X\/ad0397"},{"key":"ref_31","first-page":"365","article-title":"Section plane selection influences the results of histomorphometric studies: The example of dental implants","volume":"57","author":"Kopp","year":"2012","journal-title":"Biomed. Tech. Biomed. Eng."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cmpb.2010.12.011","article-title":"Extracting 3D information on bone remodeling in the proximity of titanium implants in SR\u03bcCT image volumes","volume":"102","author":"Sarve","year":"2011","journal-title":"Comput. Methods Programs Biomed."},{"key":"ref_33","first-page":"162","article-title":"Trabecular bone microarchitecture: A review","volume":"92","author":"Chappard","year":"2008","journal-title":"Morphol. Bull. L\u2019association Anat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1007\/s11999-010-1702-0","article-title":"Methods for assessing bone quality: A review","volume":"469","author":"Donnelly","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Alqahtani, A.R., Desai, S.R., Patel, J.R., Alqhtani, N.R., Alqahtani, A.S., Heboyan, A., Fernandes, G.V.O., Mustafa, M., and Karobari, M.I. (2023). Investigating the impact of diameters and thread designs on the Biomechanics of short implants placed in D4 bone: A 3D finite element analysis. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03370-8"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bonato, R.S., Fernandes, G.V.O., Calasans-Maia, M.D., Mello, A., Rossi, A.M., Carreira, A.C.O., Sogayar, M.C., and Granjeiro, J.M. (2022). The Influence of rhBMP-7 Associated with Nanometric Hydroxyapatite Coatings Titanium Implant on the Osseointegration: A Pre-Clinical Study. Polymers, 14.","DOI":"10.3390\/polym14194030"},{"key":"ref_37","first-page":"186","article-title":"Clinical and esthetic outcomes of implants placed in postextraction sites","volume":"24","author":"Chen","year":"2009","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Moro, A., Gasparini, G., Foresta, E., Saponaro, G., Falchi, M., Cardarelli, L., De Angelis, P., Forcione, M., Garagiola, U., and D\u2019amato, G. (2017). Alveolar Ridge Split Technique Using Piezosurgery with Specially Designed Tips. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/4530378"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1902\/jop.2010.100093","article-title":"Reconstruction of posterior mandibular alveolar ridge deficiencies with the piezoelectric hinge-assisted ridge split technique: A retrospective observational report","volume":"81","author":"Holtzclaw","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1600-0501.2006.01206.x","article-title":"Split-crest and immediate implant placement with ultra-sonic bone surgery: A 3-year life-table analysis with 230 treated sites","volume":"17","author":"Blus","year":"2006","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_41","first-page":"554","article-title":"Alternative bone expansion technique for immediate placement of implants in the edentulous posterior mandibular ridge: A clinical report","volume":"19","author":"Basa","year":"2004","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_42","first-page":"269","article-title":"Bone regeneration in the edentulous ridge expansion technique: Histologic and ultrastructural study of 20 clinical cases","volume":"19","author":"Scipioni","year":"1999","journal-title":"Int. J. Periodontics Restor. Dent."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/22\/6679\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:27:53Z","timestamp":1760113673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/22\/6679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":42,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["jcm13226679"],"URL":"https:\/\/doi.org\/10.3390\/jcm13226679","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}