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Clinical presentation is highly variable and is mostly influenced by specific organs involved, precursor protein type, and extent of amyloid deposition, often closely reflecting clinical features of the underlying disease. The most critical determinants of prognosis are cardiac and renal involvement. Diagnosis of amyloidosis is confirmed by tissue biopsy, which remains the gold standard, followed by precise amyloid fibril typing. The primary therapeutic approach is directed towards controlling underlying disease and reducing serum levels of precursor proteins to prevent further amyloid deposition. This study aims to highlight the main clinical characteristics of amyloidosis with onset in childhood, emphasizing the key differences compared to adult form.<\/jats:p>","DOI":"10.3390\/jcm13226682","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T07:47:16Z","timestamp":1730965636000},"page":"6682","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Amyloidosis in Childhood: A Review of Clinical Features and Comparison with Adult Forms"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9767-3892","authenticated-orcid":false,"given":"Giovanni Battista","family":"Zamarra","sequence":"first","affiliation":[{"name":"Department of Pediatrics, L\u2019Aquila University\u2014UNIVAQ, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5787-004X","authenticated-orcid":false,"given":"Marina","family":"Sandu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, L\u2019Aquila University\u2014UNIVAQ, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4695-4348","authenticated-orcid":false,"given":"Nicholas","family":"Caione","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, L\u2019Aquila University\u2014UNIVAQ, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Di Pasquale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, L\u2019Aquila University\u2014UNIVAQ, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Di Berardino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, L\u2019Aquila University\u2014UNIVAQ, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2644-1475","authenticated-orcid":false,"given":"Armando","family":"Di Ludovico","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cG. 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