{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:35:59Z","timestamp":1766428559523,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The natural history and prognosis of mesenteric panniculitis (MP) are not well-described. Despite referral for colonoscopy being common for this indication, colonoscopy findings in MP patients have not been reported. Therefore, we aimed to describe upper and lower gastrointestinal (GI) endoscopy findings in patients with mesenteric panniculitis, compared to matched controls, to investigate their clinical outcomes including incidence of malignancy and mortality. Methods: Retrospective case\u2013control study was conducted, and included patients who were diagnosed with mesenteric panniculitis according to Coulier radiologic criteria on abdominal computerized tomography between 1\/2005 and 12\/2019, and followed to 12\/2021. The case group was compared to a matched control group without MP on abdominal CT. Clinical data and the upper and lower endoscopies\u2019 reports were reviewed in both groups. We excluded patients who, beyond diagnosis of MP, were also diagnosed with current malignancy, significant intra-abdominal morbidity or inflammatory bowel disease. Results: The initial set of 376 patients with MP, after exclusion, included 187 patients. A total of 56.1% were male, with a mean age 60 \u00b1 15 years. Of them, 74 (39%) patients underwent follow-up CT scans, which demonstrated, in 66 (89.2%) patients, a stable MP without any aggravation. Colonoscopy was performed in 89 MP patients, and 98\/187 controls. No significant difference in the colonoscopies\u2019 findings was found between the two groups. Gastroscopy was performed in 84 MP and 79 controls. No case of gastric cancer was found. No statistically significant difference was found in the rate of gastroscopy findings. By the end of the follow-up period, malignancy was diagnosed in four patients of the MP group. None were colon cancer. The mortality rate in the MP group was 3.2%, without a significant difference compared to the controls. None were MP related. Conclusions: MP identified on abdominal CT is not associated with pathologic endoscopy findings or future diagnosis of colon cancer, and also has no impact on mortality rate. Since repeating abdominal CT did not reveal any disease progression, the necessity of follow-up imaging for MP should be carefully reconsidered.<\/jats:p>","DOI":"10.3390\/jcm13226709","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:02:54Z","timestamp":1731038574000},"page":"6709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Upper and Lower Endoscopic Findings in Mesenteric Panniculitis Patients: A Case-Control Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-1549","authenticated-orcid":false,"given":"Hagai","family":"Schweistein","sequence":"first","affiliation":[{"name":"Gastroenterology Division Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva 4941492, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Weintraub","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-5116","authenticated-orcid":false,"given":"Tzipi","family":"Hornik-Lurie","sequence":"additional","affiliation":[{"name":"Research Authority, Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Haskiya","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Rave","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-5850","authenticated-orcid":false,"given":"Ahinoam","family":"Glusman Bendersky","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva 4941492, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidal","family":"Issa","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Surgery Rabin Medical Center\u2014Hasharon Hospital, Petach Tikva 49372, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timna","family":"Naftali","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Division of Gastroenterology, Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-4402","authenticated-orcid":false,"given":"Rachel","family":"Gingold-Belfer","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva 4941492, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/00000478-199704000-00004","article-title":"Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: A single entity?","volume":"21","author":"Emory","year":"1997","journal-title":"Am. 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