{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:41Z","timestamp":1792789661093,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Queen Sof\u00eda Foundation","award":["TED2021-131676B-100"],"award-info":[{"award-number":["TED2021-131676B-100"]}]},{"name":"Fundaci\u00f3n CIEN Brain Bank Digitalization program","award":["TED2021-131676B-100"],"award-info":[{"award-number":["TED2021-131676B-100"]}]},{"name":"NextGenerationEu funds","award":["TED2021-131676B-100"],"award-info":[{"award-number":["TED2021-131676B-100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Clinicopathological research in late-life dementia has focused recently on combined neurodegenerative and vascular conditions underlying the high phenotypic heterogeneity of patients. The Vallecas Alzheimer\u2019s Reina Sof\u00eda (VARS) cohort (n &gt; 550), and particularly the series of associated brain donations (VARSpath cohort) are presented here. The aim of this study is to contribute to research in dementia with a well-characterized cohort from a single center. Methods: A total of 167 patients with complete neuropathological work-ups were analyzed here. The cohort is characterized by a high female predominance (79%), advanced age at death (88 yrs.), and a high frequency of ApoE-e4 haplotype (43%). Results: The main neuropathological diagnosis was Alzheimer\u2019s disease (79.6%), followed by vascular dementia (10.2%) and Lewy body dementia (6%). Overall, intermediate-to-high cerebrovascular disease was observed in 38.9%, Lewy body pathology in 57.5%, LATE (TDP-43 pathology) in 70.7%, ARTAG in 53%, and argyrophilic grain disease in 12% of the patients. More than one pathology with a clinically relevant burden of disease was present in 71.1% of the brains, and a selection of premortem neuropsychological and functional scores showed significant correlation with the number of co-pathologies identified in postmortem brains. Conclusions: The VARS cohort, with thorough clinical follow-up, regular blood sampling, 3-Tesla MR, and a high rate of postmortem brain donation, can provide essential multidisciplinary data in the rising age of modifying therapies and biomarkers for Alzheimer\u2019s disease and related dementias.<\/jats:p>","DOI":"10.3390\/jcm13226755","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:34:11Z","timestamp":1731324851000},"page":"6755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer\u2019s Reina Sof\u00eda Cohort"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2573-4644","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Burgue\u00f1o-Garc\u00eda","sequence":"first","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"L\u00f3pez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-7098","authenticated-orcid":false,"given":"Alicia","family":"Uceda-Heras","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Garc\u00eda-Carracedo","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Ascensi\u00f3n","family":"Zea-Sevilla","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-1732","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Rodrigo-Lara","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-329X","authenticated-orcid":false,"given":"Iago","family":"Rego-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-5455","authenticated-orcid":false,"given":"Laura","family":"Saiz-A\u00faz","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Ruiz-Valderrey","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8990-0344","authenticated-orcid":false,"given":"Francisco J.","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Guerra-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9320-6566","authenticated-orcid":false,"given":"Alberto","family":"R\u00e1bano","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda Alzheimer Center, CIEN Foundation, ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024, August 12). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wharton, S.B., Simpson, J.E., Ince, P.G., Richardson, C.D., Merrick, R., Matthews, F.E., Brayne, C., and CFAS (2023). Insights into the pathological basis of dementia from population-based neuropathology studies. Neuropathol. Appl. Neurobiol., 49.","DOI":"10.1111\/nan.12923"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/YCO.0000000000000843","article-title":"Recent research advances in young-onset dementia","volume":"36","author":"Loi","year":"2023","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0306-8","article-title":"Dementia with Lewy bodies: An update and outlook","volume":"14","author":"Outeiro","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-010-0691-0","article-title":"Tau, prions and A\u03b2: The triad of neurodegeneration","volume":"121","author":"Reiniger","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1474-4422(23)00114-X","article-title":"Progression of cerebral amyloid angiopathy: A pathophysiological framework","volume":"22","author":"Koemans","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.3233\/JAD-132288","article-title":"Argyrophilic grain pathology as a natural model of tau propagation","volume":"40","author":"Rodal","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e13213","DOI":"10.1111\/bpa.13213","article-title":"LATE-NC in Alzheimer\u2019s disease: Molecular aspects and synergies","volume":"34","author":"Gawor","year":"2024","journal-title":"Brain Pathol."},{"key":"ref_10","first-page":"897","article-title":"Novel Blood-Based Biomarkers and Disease Modifying Therapies for Alzheimer\u2019s Disease. Are We Ready for the New Era?","volume":"11","author":"Kalsi","year":"2024","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3233\/JAD-2010-101149","article-title":"Alzheimer Center Reina Sofia Foundation: Fighting the disease and providing overall solutions","volume":"21","author":"Avila","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JAD-2011-110875","article-title":"Promoting research in advanced dementia: Early clinical results of the Alzheimer Center Reina Sof\u00eda Foundation","volume":"28","author":"Osorio","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jnen\/nlab122","article-title":"Advances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future","volume":"81","author":"Shakir","year":"2022","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jalz.2015.01.004","article-title":"Combined Alzheimer\u2019s disease and cerebrovascular staging explains advanced dementia cognition","volume":"11","author":"Calero","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3233\/JAD-200600","article-title":"Pathological Correlations of Neuropsychiatric Symptoms in Institutionalized People with Dementia","volume":"78","author":"Amaya","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/infdis\/jiac268","article-title":"Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study","volume":"227","author":"Calero","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/alz.12942","article-title":"A novel histological staging of hippocampal sclerosis that is evident in gray matter loss in vivo","volume":"19","author":"Iglesias","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1002\/alz.13352","article-title":"Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior","volume":"19","author":"Iglesias","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/alz.13695","article-title":"Three-dimensional histology reveals dissociable human hippocampal long-axis gradients of Alzheimer\u2019s pathology","volume":"20","author":"Bress","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/brain\/awae035","article-title":"Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles","volume":"147","author":"Pastor","year":"2024","journal-title":"Brain"},{"key":"ref_21","first-page":"767","article-title":"Revalidaci\u00f3n y normalizaci\u00f3n del Mini-Examen Cognoscitivo (primera versi\u00f3n en castellano del Mini-Mental Status Examination) en la poblaci\u00f3n general geri\u00e1trica [Revalidation and standardization of the cognition mini-exam (first Spanish version of the Mini-Mental Status Examination) in the general geriatric population]","volume":"112","author":"Lobo","year":"1999","journal-title":"Med. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"ref_23","first-page":"653","article-title":"Functional assessment staging (FAST)","volume":"24","author":"Reisberg","year":"1988","journal-title":"Psychopharmacol. Bull."},{"key":"ref_24","first-page":"629","article-title":"Brief Cognitive Rating Scale (BCRS)","volume":"24","author":"Reisberg","year":"1988","journal-title":"Psychopharmacol. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br. J. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-020-02255-2","article-title":"Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: A multi-centre study","volume":"141","author":"Attems","year":"2021","journal-title":"Acta Neuropathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-022-02524-2","article-title":"LATE-NC staging in routine neuropathologic diagnosis: An update","volume":"145","author":"Nelson","year":"2023","journal-title":"Acta Neuropathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-016-1537-1","article-title":"Updated TDP-43 in Alzheimer\u2019s disease staging scheme","volume":"131","author":"Josephs","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/jnen\/63.9.911","article-title":"Staging of argyrophilic grains: An age-associated tauopathy","volume":"63","author":"Saito","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1212\/WNL.0b013e31824e8e7f","article-title":"Staging and natural history of cerebrovascular pathology in dementia","volume":"78","author":"Deramecourt","year":"2012","journal-title":"Neurology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/aww214","article-title":"Vascular cognitive impairment neuropathology guidelines (VCING): The contribution of cerebrovascular pathology to cognitive impairment","volume":"139","author":"Skrobot","year":"2016","journal-title":"Brain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jneumeth.2009.06.033","article-title":"Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assays","volume":"183","author":"Calero","year":"2009","journal-title":"J. Neurosci. Methods"},{"key":"ref_37","first-page":"151","article-title":"Brain Donation by Proxy: Are There Predictors in Neurodegenerative Dementia?","volume":"1","author":"Dobato","year":"2014","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.trci.2016.09.002","article-title":"Multiple comorbid neuropathologies in the setting of Alzheimer\u2019s disease neuropathology and implications for drug development","volume":"3","author":"Rabinovici","year":"2016","journal-title":"Alzheimer\u2019s Dement"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00401-018-1872-5","article-title":"Non-Alzheimer\u2019s contributions to dementia and cognitive resilience in The 90+ Study","volume":"136","author":"Robinson","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jalz.2016.09.015","article-title":"Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample","volume":"13","author":"Brenowitz","year":"2017","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1093\/brain\/awab099","article-title":"Comorbid neuropathological diagnoses in early versus late-onset Alzheimer\u2019s disease","volume":"144","author":"Spina","year":"2021","journal-title":"Brain"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ana.25392","article-title":"Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders","volume":"85","author":"Coughlin","year":"2019","journal-title":"Ann. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Thomas, D.X., Bajaj, S., McRae-McKee, K., Hadjichrysanthou, C., Anderson, R.M., and Collinge, J. (2020). Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer\u2019s disease neuropathology. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-71305-2"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13195-018-0450-3","article-title":"Prediction models for dementia and neuropathology in the oldest old: The Vantaa 85+ cohort study","volume":"11","author":"Hall","year":"2019","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00401-024-02716-y","article-title":"Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies","volume":"147","author":"Hiya","year":"2024","journal-title":"Acta Neuropathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/brain\/awy146","article-title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","volume":"141","author":"Robinson","year":"2018","journal-title":"Brain"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00401-017-1709-7","article-title":"Interactions of pathological proteins in neurodegenerative diseases","volume":"134","author":"Attems","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s40478-021-01260-0","article-title":"The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer\u2019s dementia in older persons","volume":"9","author":"Agrawal","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13024-023-00653-0","article-title":"TDP-43 pathology is associated with increased tau burdens and seeding","volume":"18","author":"Tsaka","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Katsumata, Y., Wu, X., Aung, K.Z., Gauthreaux, K., Mock, C., Forrest, S.L., Kovacs, G.G., and Nelson, P.T. (2024). Pathologic correlates of aging-related tau astrogliopathy: ARTAG is associated with LATE-NC and cerebrovascular pathologies, but not with ADNC. Neurobiol. Dis., 191.","DOI":"10.1016\/j.nbd.2024.106412"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"fcae141","DOI":"10.1093\/braincomms\/fcae141","article-title":"Multiple system atrophy with amyloid-\u03b2-predominant Alzheimer\u2019s disease neuropathologic change","volume":"6","author":"Kon","year":"2024","journal-title":"Brain Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e13210","DOI":"10.1111\/bpa.13210","article-title":"The molecular spectrum of amyloid-beta (A\u03b2) in neurodegenerative diseases beyond Alzheimer\u2019s disease","volume":"34","author":"Ichimata","year":"2024","journal-title":"Brain Pathol."},{"key":"ref_53","first-page":"7384","article-title":"Pathways to personalized medicine-Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer\u2019s disease","volume":"20","author":"Arnold","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/s41591-024-02988-7","article-title":"Revised criteria for the diagnosis and staging of Alzheimer\u2019s disease","volume":"30","author":"Jack","year":"2024","journal-title":"Nat. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/22\/6755\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:29:37Z","timestamp":1760113777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/22\/6755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":54,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["jcm13226755"],"URL":"https:\/\/doi.org\/10.3390\/jcm13226755","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]}}}