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Antibodies (Abs) to anti-aminoacyl-transfer ribonucleic acid synthetase (ARS) are linked to ILD in patients with idiopathic inflammatory myopathies (IIM). There have been limited studies of anti-ARS Abs in RA. In this study, we examined anti-ARS Abs in ILD in patients with RA. Methods: Anti-ARS Abs in serum from patients with RA were measured. Results: There were higher anti-ARS Ab levels in RA patients with ILD (mean \u00b1 SDM, 16.3 \u00b1 32.3 vs. 7.4 \u00b1 7.0 (Index), p = 5.58 \u00d7 10\u221212), usual interstitial pneumonia (14.4 \u00b1 24.4 vs. 7.4 \u00b1 7.0 [Index], p = 3.14 \u00d7 10\u221212), and nonspecific interstitial pneumonia (17.9 \u00b1 37.7 vs. 7.4 \u00b1 7.0 (Index), p = 5.07 \u00d7 10\u22125) compared with patients without chronic lung disease. The area under the curve (AUC) of the receiver operating characteristic curve for anti-ARS Ab was too low to allow for discrimination among RA patients with\/without chronic lung disease (0.608, 95% confidence interval (CI) 0.560\u20130.655, p = 8.69 \u00d7 10\u22126). Multiple logistic regression analyses of age, smoking status, anti-ARS Abs, as well as Steinbrocker stage generated an ARS-index with a high AUC value (0.707, 95%CI 0.662\u20130.752, p = 2.20 \u00d7 10\u221219). Conclusions: Anti-ARS Abs are related to ILD pathogenesis in RA and may be a biomarker for ILD.<\/jats:p>","DOI":"10.3390\/jcm13226761","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:34:11Z","timestamp":1731324851000},"page":"6761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Shomi","family":"Oka","sequence":"first","affiliation":[{"name":"Department of Rheumatology, NHO Tokyo National Hospital, Kiyose 204-8585, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Tokyo National Hospital, Kiyose 204-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-8056","authenticated-orcid":false,"given":"Hiroshi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Tokyo National Hospital, Kiyose 204-8585, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"},{"name":"Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu 183-8524, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Himeji Medical Center, Himeji 670-8520, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misuzu","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Himeji Medical Center, Himeji 670-8520, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"},{"name":"Department of Internal Medicine, Sagami Seikyou Hospital, Sagamihara 252-0303, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Komiya","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"},{"name":"Department of Clinical Laboratory, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Saisho","sequence":"additional","affiliation":[{"name":"Department of Orthopedics\/Rheumatology, NHO Miyakonojo Medical Center, Miyakonojo 885-0014, Japan"},{"name":"Tanimura Hospital, Nobeoka 882-0041, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedics\/Rheumatology, NHO Miyakonojo Medical Center, Miyakonojo 885-0014, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, NHO Nagoya Medical Center, Nagoya 460-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-3211","authenticated-orcid":false,"given":"Toshihiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"},{"name":"Department of Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara 252-0392, Japan"},{"name":"Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-890, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Migita","sequence":"additional","affiliation":[{"name":"Clinical Research Center, NHO Nagasaki 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