{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:08:59Z","timestamp":1793740139373,"version":"4.6.1"},"reference-count":34,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Deep endometriosis (DE) is a special form of endometriosis, one of the most common benign diseases in gynecology. In the specific case of DE, ectopic endometrium can be found not only in peritoneal but also in deeper tissue layers or even as parenchymal organ infiltration. Symptoms include dysmenorrhea, dyspareunia, dyschezia, and dysuria, as well as asymptomatic hydronephrosis or other organ dysfunctions. Due to a pathogenesis of the disease that has not been conclusively clarified to date, no causal therapy exists, which is why surgical resection of DE is still the gold standard for symptomatic cases. Methods: This article retrospectively describes the challenges in diagnosis and surgical treatment of DE at a German Level III Endometriosis Center, with a focus on diagnosis and surgical treatment, as well as the analysis of perioperative and postoperative complications. Results: The surgical treatment of DE is performed in most cases by minimally invasive laparoscopy (94.1%), whereas complex procedures such as ureterolysis, adhesiolysis, or preparation of the rectovaginal septum are considered standard procedures as well. The complexity of the procedures is further underlined by a high need for interdisciplinary operations (28%). Despite high complexity, severe postoperative complications occurred in only 3.1% of surgeries, with the complication rate being significantly higher whenever bowel surgery was necessary for DE resection. Conclusions: Our results emphasize the complexity and interdisciplinary nature of the disease. Therefore, treatment should preferably take place at an endometriosis center of the highest level with experienced, well-coordinated teams.<\/jats:p>","DOI":"10.3390\/jcm13226783","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T06:28:32Z","timestamp":1731392912000},"page":"6783","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostics and Surgical Treatment of Deep Endometriosis\u2014Real-World Data from a Large Endometriosis Center"],"prefix":"10.3390","volume":"13","author":[{"given":"Marcel","family":"Grube","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"},{"name":"Department of Gynecology and Obstetrics, Diak Klinikum Schwaebisch Hall, Diakoniestrasse 10, 74523 Schwaebisch Hall, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Castan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Drechsel-Grau","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"},{"name":"Department of Urology, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9000 St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Praetorius","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"},{"name":"Department of Gynecology and Obstetrics, Diak Klinikum Schwaebisch Hall, Diakoniestrasse 10, 74523 Schwaebisch Hall, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Greif","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology, University Hospital Tuebingen, Liebermeisterstra\u00dfe 8, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Staebler","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology, University Hospital Tuebingen, Liebermeisterstra\u00dfe 8, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-561X","authenticated-orcid":false,"given":"Felix","family":"Neis","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-9438","authenticated-orcid":false,"given":"Katharina","family":"Rall","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8628-6745","authenticated-orcid":false,"given":"Bernhard","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kommoss","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"},{"name":"Department of Gynecology and Obstetrics, Diak Klinikum Schwaebisch Hall, Diakoniestrasse 10, 74523 Schwaebisch Hall, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3485-3847","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Andress","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/oxfordjournals.humrep.a019270","article-title":"Delay in the diagnosis of endometriosis: A survey of women from the USA and the UK","volume":"11","author":"Hadfield","year":"1996","journal-title":"Hum. 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