{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:21:06Z","timestamp":1788301266833,"version":"build-2803163510"},"reference-count":96,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Early detection and rehabilitation interventions are essential to optimise motor function in infants and young children with unilateral cerebral palsy. In this paper we report a clinical framework aimed at enhancing upper limb therapy for infants and young children with unilateral cerebral palsy during a sensitive period of brain development. We describe two major therapeutic approaches based on motor learning principles and evidence: constraint-induced movement therapy and bimanual therapy. These two therapies have demonstrated efficacy in older children and emerging evidence is available for their application to infants younger than 2 years of age. To provide clinicians with guidance as to when to implement these therapies, we discuss the key consideration when undertaking upper limb therapy programs. In addition, we describe the factors to consider when choosing which approach may be suitable for an individual child and family. Detailed strategies for implementing these therapies in infants and young children of different ability levels are given.<\/jats:p>","DOI":"10.3390\/jcm13226873","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T05:33:04Z","timestamp":1731648784000},"page":"6873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Upper Limb Therapy for Infants and Young Children with Unilateral Cerebral Palsy: A Clinical Framework"],"prefix":"10.3390","volume":"13","author":[{"given":"Susan","family":"Greaves","sequence":"first","affiliation":[{"name":"CPGroup, 74 Faraday Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-4141","authenticated-orcid":false,"given":"Brian","family":"Hoare","sequence":"additional","affiliation":[{"name":"CPGroup, 74 Faraday Street, Carlton, VIC 3053, Australia"},{"name":"School of Allied Health, Australian Catholic University, 115 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Discipline of Occupational Therapy, La Trobe University, Plenty Road, Bundoora, VIC 3086, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/08830738221124365","article-title":"Upper Limb Onabotulinumtoxin A Injections in Children Under 2 Years with Cerebral Palsy: A Retrospective Chart Review","volume":"37","author":"Centorame","year":"2022","journal-title":"J. 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