{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:50:53Z","timestamp":1790013053367,"version":"4.0.1"},"reference-count":33,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Trigeminal neuralgia (TN) is a disease that causes severe pain that can seriously affect the quality of life. This study aimed to compare the effectiveness of two different low-level laser therapies (LLLT) as alternatives to medical treatment to reduce pain and improve the quality of life in patients with TN. Methods: A total of 45 patients were randomly divided into 3 groups. In the first group, a new-generation diode laser (GRR laser) was applied at predetermined points in the trigeminal nerve line. In the second group, a low-level neodymium-doped yttrium aluminum garnet (Nd:YAG) laser was applied along the affected nerve line. The placebo group received the same protocol with a Nd:YAG laser without the device switched on. The scores were recorded pre- and post-treatment using the Brief Pain Inventory-Facial (BPI-facial) scale. Results: A statistically significant difference was found between the pre- and post-treatment values of all four variables in the GRR laser, Nd:YAG laser, and placebo groups. When the post-treatment values were compared, statistically significant differences were found between the groups in pain frequency, pain intensity, and interference in facial-specific activities, but no differences were found in general activities. Conclusions: Both LLLTs can be considered alternative treatment modalities for TN, but the GRR laser treatment was more effective than the Nd:YAG laser treatment in reducing pain and improving the quality of life in patients with TN.<\/jats:p>","DOI":"10.3390\/jcm13226890","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T09:30:25Z","timestamp":1732008625000},"page":"6890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"\u0130rem","family":"Karag\u00f6zo\u011flu","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Prosthodontics, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Demirkol","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Prosthodontics, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Parlar \u00d6z","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Prosthodontics, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6k\u00e7e","family":"Ke\u00e7eci","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Prosthodontics, Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University, Kahramanmara\u015f 46050, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beste","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Prosthodontics, Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University, Kahramanmara\u015f 46050, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-6098","authenticated-orcid":false,"given":"Mutlu","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Clinic of Masticatory Disorders and Dental Biomaterials, Center for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"ref_1","first-page":"226","article-title":"Classification of chronic pain: Descriptions of chronic pain syndromes and definitions of pain terms","volume":"3","author":"Merskey","year":"1986","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3949\/ccjm.90a.22052","article-title":"Guidelines for the management of trigeminal neuralgia","volume":"90","author":"Chong","year":"2023","journal-title":"Cleve Clin. 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