{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:21Z","timestamp":1760146641726,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chair Alcon-FOM-UVEG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Corneal oedema is known for changing the cornea\u2019s optical properties, particularly its ability to transmit ultraviolet (UV) light, which is crucial for visual clarity and eye health. This study explores how changes in corneal thickness in oedematous states affect UV light transmission. Methods: This study included 107 porcine eyes with artificially induced corneal oedema. Corneal thickness (CCT) was measured histologically, UV transmittance was assessed using a UV\/VIS spectrometer, and endothelial cell parameters were evaluated with specular microscopy. Statistical analyses included the Kruskal\u2013Wallis test, Mann\u2013Whitney U test, and Spearman\u2019s correlation. Results: The findings indicated a significant increase in CCT in oedematous corneas at 24 and 48 h post extraction compared to controls, with median CCT values of 816.59 \u00b1 139.71 \u03bcm for controls, 1022.40 \u00b1 234.48 \u03bcm at 24 h, and 1074.21 \u00b1 220.83 \u03bcm at 48 h (p &lt; 0.001). UV transmittance (395\u2013280 nm) decreased substantially, dropping from 50.79 \u00b1 7.65% in controls to 43.24 \u00b1 5.35% at 24 h and 39.66 \u00b1 6.51% at 48 h (p &lt; 0.001). There was a significant negative correlation between CCT and UV transmittance (\u03c1 = \u22120.346, p &lt; 0.001). Endothelial parameters showed notable changes: maximum cell area (AreaMAX) decreased at 24 and 48 h, while endothelial cell density (ECD) increased at 24 h. Conclusions: Our study found a substantial inverse link between CCT and UV light transmission in oedematous corneas, highlighting the importance of UV protection, especially in individuals who are prone to recurrent oedema. Changes in CCT and endothelial measures, such as AreaMAX and ECD, are useful signs of corneal integrity. However, the study\u2019s small sample size and potential tissue modifications during processing need more research with bigger, in vivo samples to corroborate these findings and improve therapeutic use.<\/jats:p>","DOI":"10.3390\/jcm13237228","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:28:01Z","timestamp":1732778881000},"page":"7228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Corneal Oedema on UV Light Transmission: An Experimental Study in Porcine Eyes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9363-5482","authenticated-orcid":false,"given":"Celeste","family":"Briceno-Lopez","sequence":"first","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner, 50, Burjassot, E-46100 Valencia, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner, 50, E-46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-0214","authenticated-orcid":false,"given":"M\u00aa Carmen","family":"Garc\u00eda-Domene","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner, 50, Burjassot, E-46100 Valencia, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner, 50, E-46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Peris-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Anterior Segment and Cornea and External Eye Diseases Unit, Fundaci\u00f3n de Oftalmolog\u00eda M\u00e9dica, Av. P\u00edo Baroja, 12, E-46015 Valencia, Spain"},{"name":"Surgery Department, Faculty of Medicine, Universitat de Val\u00e8ncia, Av. Blasco Ib\u00e1\u00f1ez, 15, E-46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-8429","authenticated-orcid":false,"given":"M\u00aa Jose","family":"Luque-Cobija","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner, 50, Burjassot, E-46100 Valencia, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner, 50, E-46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-4039","authenticated-orcid":false,"given":"M\u00aa Amparo","family":"D\u00edez-Ajenjo","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner, 50, Burjassot, E-46100 Valencia, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner, 50, E-46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-1431","authenticated-orcid":false,"given":"Neus","family":"Burguera-Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner, 50, Burjassot, E-46100 Valencia, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner, 50, E-46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/08820538.2019.1620796","article-title":"Methods for Assessing Corneal Opacity","volume":"34","author":"Dohlman","year":"2019","journal-title":"Semin. 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