{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:39:31Z","timestamp":1791499171555,"version":"4.3.4"},"reference-count":18,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Predicting whether extracorporeal membrane oxygenation (ECMO) treatment duration affects prognosis is important both medically and economically. Methods: We conducted a retrospective, multicenter study to better understand the outcomes of patients treated with veno-venous (VV) ECMO over a prolonged duration, analyzing data from the Israel ECMO registry. The study included all adult patients treated with VV-ECMO due to COVID-19-induced respiratory failure. The primary outcomes were survival rates up to 180 days from cannulation. Results: One hundred and eighty-eight patients were included in the study. The median age was 50 years (IQR 42, 50), and 69% were male. Patients were mechanically ventilated for a median of 2.5 days before cannulation (IQR 0.5, 5). The mean ECMO support duration was 29.9 days, with a maximal duration of 189.9 days. The survival rate for 180 days was 56%. We found no change in survival for patients on ECMO for 14, 28, or 56 days. Every day of mechanical ventilation before cannulation correlated with an 11% greater risk for prolonged ECMO treatment (p = 0.01). Conclusions: COVID-19-induced ARDS patients treated with VV-ECMO for prolonged duration had the same prognosis as those treated for short periods of time. The longer the duration of mechanical ventilation before ECMO cannulation, the higher the risk for prolonged ECMO treatment.<\/jats:p>","DOI":"10.3390\/jcm13237252","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T08:24:14Z","timestamp":1732868654000},"page":"7252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes and Prognosis of COVID-19-Induced Adult Respiratory Distress Syndrome Patients Treated with Prolonged Veno-Venous Extracorporeal Membrane Oxygenation: A Retrospective Multicenter Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Amram","family":"Bitan","sequence":"first","affiliation":[{"name":"Medical Division, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitzan","family":"Sagie","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Ilgiyaev","sequence":"additional","affiliation":[{"name":"Shamir Medical Center, Faculty of Medicine, University of Tel Aviv, Be\u2019er Ya\u2019akov 703301, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekel","family":"Stavi","sequence":"additional","affiliation":[{"name":"Division of Anesthesia, Pain Management, and Intensive Care, Tel-Aviv Sourasky Medical Center\u2014Ichilov Hospital, Faculty of Medicine, University of Tel Aviv, Tel Aviv 6423906, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Makhoul","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Rambam Health Care Campus, Haifa 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Soroksky","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Wolfson Medical Center, Faculty of Medicine, University of Tel Aviv, Holon 5822012, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigal","family":"Kasif","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tel HaShomer Hospital, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Novack","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Galante","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/MAT.0000000000001067","article-title":"Predicting Survival of Adult Respiratory Failure Patients Receiving Prolonged (\u226514 Days) Extracorporeal Membrane Oxygenation","volume":"66","author":"Posluszny","year":"2020","journal-title":"ASAIO J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/MAT.0b013e3182904a52","article-title":"Extracorporeal Life Support Organization Registry Report 2012","volume":"59","author":"Paden","year":"2013","journal-title":"ASAIO J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MAT.0000000000000475","article-title":"Extracorporeal Life Support Organization Registry International Report 2016","volume":"63","author":"Thiagarajan","year":"2017","journal-title":"ASAIO J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0140-6736(09)61069-2","article-title":"Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial","volume":"374","author":"Peek","year":"2009","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201205-0815OC","article-title":"Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: A cohort study and propensity-matched analysis","volume":"187","author":"Pham","year":"2013","journal-title":"Am. 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