{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:07:19Z","timestamp":1780330039118,"version":"3.54.1"},"reference-count":35,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Region Stockholm","award":["RS2020-0731"],"award-info":[{"award-number":["RS2020-0731"]}]},{"name":"Region Stockholm","award":["RS2021-0932"],"award-info":[{"award-number":["RS2021-0932"]}]},{"name":"Region Stockholm","award":["2021-0273"],"award-info":[{"award-number":["2021-0273"]}]},{"name":"Swedish Heart-Lung Foundation","award":["RS2020-0731"],"award-info":[{"award-number":["RS2020-0731"]}]},{"name":"Swedish Heart-Lung Foundation","award":["RS2021-0932"],"award-info":[{"award-number":["RS2021-0932"]}]},{"name":"Swedish Heart-Lung Foundation","award":["2021-0273"],"award-info":[{"award-number":["2021-0273"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The long-term risk of cardiovascular and thrombotic events following severe COVID-19 remains largely unknown. This study aimed to assess the risk of atherosclerotic cardiovascular disease (ASCVD) within one year after hospital discharge in patients who received intensive care for severe COVID-19. Methods: A register-based nationwide case-control study on a cohort of patients with severe COVID-19 (cases) requiring mechanical ventilation and discharged alive without experiencing cardiovascular or thrombotic events during their hospital stay. Each case was matched (age, sex, district of residence) with up to 10 population-based controls. The primary outcome was ASCVD occurring after hospital discharge, defined as a composite endpoint, including myocardial infarction (MI), unstable angina pectoris and ischemic stroke. Secondary endpoints were MI, stroke, all-cause mortality, and venous thromboembolic events. Hazard ratio (HR) (95% CI) was used with adjustments for age, sex, socioeconomic factors, and co-morbidities. Results: In total, 31,375 individuals (70% men, median age 62 years) were included, of which 2854 had severe COVID-19 and 26,885 matched control subjects. The adjusted HR for ASCVD during the first year compared to control subjects was 3.1 (95% CI 1.7\u20135.4). Adjusted HRs for secondary outcomes for myocardial infarction were 2.0 (95% CI 0.8\u20135.3), for stroke 1.9 (95% CI 0.7\u20135.3), for pulmonary embolism 49.4 (95% CI 28.0\u201387.1), and deep venous thrombosis (DVT) 16.0 (95% CI 7.8\u201332.6). Conclusions: Severe COVID-19 requiring intensive care was associated with a substantial increase in 1-year risk for ASCVD and venous thromboembolic events.<\/jats:p>","DOI":"10.3390\/jcm13237265","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T08:24:14Z","timestamp":1732868654000},"page":"7265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["From Crisis to Complications: A Nationwide Cohort Study Assessing One-Year Cardiovascular and Thromboembolic Risks After Severe COVID-19 Compared to Matched Controls"],"prefix":"10.3390","volume":"13","author":[{"given":"Andreas","family":"Liliequist","sequence":"first","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, 171 64 Stockholm, Sweden"},{"name":"Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, 171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-895X","authenticated-orcid":false,"given":"Robin","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"H\u00e4bel","sequence":"additional","affiliation":[{"name":"Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institute, 171 65 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-6240","authenticated-orcid":false,"given":"Marcus","family":"St\u00e5hlberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, 171 64 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Nordberg","sequence":"additional","affiliation":[{"name":"Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, 171 76 Stockholm, Sweden"},{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, 118 83 Stockholm, Sweden"},{"name":"Department of Physiology and Pharmacology, Karolinska Institute, 171 65 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-022-05522-2","article-title":"The WHO estimates of excess mortality associated with the COVID-19 pandemic","volume":"613","author":"Msemburi","year":"2023","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.20050828","article-title":"Multiple organ infection and the pathogenesis of SARS","volume":"202","author":"Gu","year":"2005","journal-title":"J. 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