{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:32:13Z","timestamp":1775457133127,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cocaine use can cause multiple cardiovascular complications, including heart failure. Aim: This general review of the literature delivers data on the relationship between cocaine consumption and the development of heart failure, as well as the elements of its diagnosis and management. Methods: A literature search was carried out using the PubMed, Web Of Science, and Google Scholar bibliographic databases over the period of 2007\u20132022 using the following keywords: \u201ccocaine\u201d AND \u201cheart failure\u201d NOT \u201cacute heart disease\u201d. The exclusion criteria exempted studies carried out on animals, along with articles not written in English. Results and Discussion: A total of 27 articles (11 reviews, 10 clinical studies, 4 letters to the editor, and 2 clinical cases) were included. The prevalence of heart failure among cocaine users varies from one study to another (2.5%, 5.3%, 6.2%, or even 20%); however, when patients have a history of cocaine consumption, the prevalence of heart failure is higher than that ordinarily found in the young population (&lt;0.1% to 0.5%). Cocaine consumption has a number of serious cardiotoxic effects that can lead to heart failure. According to the studies analysed, heart failure should be treated with beta-blockers, even in the event of long-term cocaine use, with a preference for carvedilol. Conclusions: Despite previous concerns about the use of beta-blockers in cocaine users, treatment with beta-blockers (particularly carvedilol) may actually result in measurable clinical improvement. Cocaine withdrawal remains essential for optimal treatment.<\/jats:p>","DOI":"10.3390\/jcm13237275","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:48:56Z","timestamp":1733226536000},"page":"7275","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Narrative Review of Heart Failure Related to Cocaine Consumption and Its Therapeutic Management"],"prefix":"10.3390","volume":"13","author":[{"given":"Catl\u00e9ya","family":"Alawo\u00e8","sequence":"first","affiliation":[{"name":"Addictovigilance Centre, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Chapet","sequence":"additional","affiliation":[{"name":"Cardiology Department, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-9687","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"Cardiology Intensive Care Department, PhyMedExp, INSERM U1046, CNRS UMR 9214, Montpellier Faculty of Medicine, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-9099","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Peyri\u00e8re","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre, INSERM U1058, Pathogenesis and Control of Chronic Infections (PCCI), Montpellier Faculty of Pharmacy, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9811","authenticated-orcid":false,"given":"C\u00e9line","family":"Eiden","sequence":"additional","affiliation":[{"name":"Addictovigilance Centre, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","unstructured":"(2024, September 30). Th\u00e9ma Coca\u00efne OFDT 2023: Evolution de l\u2019Usage dans l\u2019Ann\u00e9e de Coca\u00efne Parmi les Adultes (18\u201364-Ans), Donn\u00e9es du Barom\u00e8tre Sant\u00e9 de Sant\u00e9 Publique France. Available online: https:\/\/www.ofdt.fr\/sites\/ofdt\/files\/2023-08\/field_media_document-5869-epfxco2d3.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/fcp.12603","article-title":"Health consequences of cocaine use in France: Data from the French Addictovigilance Network","volume":"35","author":"Eiden","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1532-429X-16-26","article-title":"Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T","volume":"16","author":"Maceira","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.amjcard.2017.03.034","article-title":"Comparison of Frequency of Cardiovascular Events and Mortality in Patients With Heart Failure Using Versus Not Using Cocaine","volume":"119","author":"Nguyen","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/clc.22897","article-title":"Improvement in clinical outcomes of patients with heart failure and active cocaine use after \u03b2-blocker therapy","volume":"41","author":"Lopez","year":"2018","journal-title":"Clin. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1177\/1074248418778550","article-title":"Effect of \u03b2-blocker Therapy on Hospital Readmission and Mortality in Heart Failure Patients With Concurrent Cocaine Use","volume":"23","author":"Egbuche","year":"2018","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jchf.2019.06.010","article-title":"Carvedilol Among Patients With Heart Failure With a Cocaine-Use Disorder","volume":"7","author":"Banerji","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijcard.2018.08.058","article-title":"Clinical outcomes of \u0392-blocker therapy in cocaine-associated heart failure","volume":"277","author":"Lopez","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_9","first-page":"70","article-title":"Detection of subclinical myocardial dysfunction in cocaine addicts with feature tracking cardiovascular magnetic resonance","volume":"22","author":"Maceira","year":"2020","journal-title":"J. Cardiovasc. Magn. Reson. Off. J. Soc. Cardiovasc. Magn. Reson."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.amjcard.2022.04.028","article-title":"Outcomes in Patients With Heart Failure Using Cocaine","volume":"176","author":"Garry","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_11","first-page":"101189","article-title":"Effect of Cocaine, Amphetamine, and Cannabis Use Disorders on 30-day Readmissions of Patients with Heart Failure","volume":"25","author":"Thyagaturu","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cjca.2021.11.002","article-title":"Heavy Burden of Toxic. Dilated Cardiomyopathy: Among Young: Adults: A Retrospective Study and Review of the Literature","volume":"38","author":"Massot","year":"2022","journal-title":"Can. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00059-013-3976-y","article-title":"Successful treatment of cocaine-induced cardiotoxicity with carvedilol therapy","volume":"40","author":"Tellice","year":"2015","journal-title":"Herz"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1536\/ihj.21-139","article-title":"Severe Heart Failure in a Young Cocaine-User","volume":"62","author":"Bekki","year":"2021","journal-title":"Int. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03256574","article-title":"Cocaine cardiotoxicity: A review of the pathophysiology. pathology, and treatment options","volume":"9","author":"Phillips","year":"2009","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pcad.2009.11.004","article-title":"Alcoholic and cocaine-associated cardiomyopathies","volume":"52","author":"Awtry","year":"2010","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.yrtph.2013.09.002","article-title":"Influence of mitochondrion toxic agents on the cardiovascular system","volume":"67","author":"Finsterer","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"H1453","DOI":"10.1152\/ajpheart.00554.2015","article-title":"Drug-induced mitochondrial dysfunction and cardiotoxicity","volume":"309","author":"Varga","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cnc.2015.07.002","article-title":"Mechanisms of-Cardiotoxicity and the Development of Heart Failure","volume":"27","author":"Lee","year":"2015","journal-title":"Crit. Care Nurs. Clin. N. Am."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/med.21476","article-title":"Comprehensive review of cardiovascular toxicity of drugs and related agents","volume":"38","author":"Costa","year":"2018","journal-title":"Med. Res. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2017.154","article-title":"Epidemiology of cardiovascular disease in young individuals","volume":"15","author":"Andersson","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jchf.2019.07.002","article-title":"Cocaine, Heart Failure, and Carvedilol: Triangulating the Safety of- \u00df-Blocker Therapy","volume":"7","author":"Page","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1985379","DOI":"10.1155\/2020\/1985379","article-title":"Beta Blocker Therapy in Heart Failure Patients with Active Cocaine Use: A Systematic Review","volume":"2020","author":"Mann","year":"2020","journal-title":"Cardiol. Res. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.cardfail.2021.05.023","article-title":"Drugs of Abuse and Heart Failure","volume":"27","author":"Grubb","year":"2021","journal-title":"J. Card. Fail."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cjca.2022.06.027","article-title":"Early-Onset Cardiovascular Disease From Cocaine, Amphetamines, Alcohol, and Marijuana","volume":"38","author":"Lavie","year":"2022","journal-title":"Can. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.ijcard.2013.03.187","article-title":"Beta blocker treatment of heart failure patients with ongoing cocaine use","volume":"168","author":"Littmann","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.amjcard.2017.10.036","article-title":"Safety and Efficacy of Beta Blockers in Cocaine-Using Patients With Heart Failure","volume":"121","author":"Richards","year":"2018","journal-title":"Am. J. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijcard.2018.10.003","article-title":"Beta-blockers: A real antidote for cocaine-related heart disease?","volume":"277","author":"Barison","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijcard.2018.12.023","article-title":"\u0392eta-blocker therapy in cocaine-associated heart failure: Attempting to mitigate the risk","volume":"283","author":"Schwier","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.amjcard.2008.06.045","article-title":"Illicit stimulant use in a United States heart failure population presenting to the emergency department (from the Acute Decompensated Heart Failure National Registry Emergency Module)","volume":"102","author":"Diercks","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1136\/heartjnl-2023-322520","article-title":"Prevalence and impact of recreational drug use in patients with acute cardiovascular events","volume":"109","author":"Pezel","year":"2023","journal-title":"Heart"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/2047487318806658","article-title":"Tobacco smoking and the risk of heart failure A systematic review and meta-analysis of prospective studies","volume":"26","author":"Aune","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.jacc.2022.03.377","article-title":"Cigarette Smoking, Cessation, and Risk of Heart Failure With Preserved and Reduced Ejection Fraction","volume":"79","author":"Ding","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","first-page":"e009459","article-title":"Alcohol intake in patients with cardiomyopathy and heart failure: Consensus and controversy","volume":"15","author":"Andersoon","year":"2022","journal-title":"Circ. Heart Fail."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/CIR.0000000000001063","article-title":"AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American HeartAssociation Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.therap.2022.11.008","article-title":"Follow-up of patients hospitalized for cocaine detoxification. Inpatient cocaine detoxification","volume":"78","author":"Roy","year":"2023","journal-title":"Therapie"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/23\/7275\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:42:41Z","timestamp":1760114561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/23\/7275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":36,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13237275"],"URL":"https:\/\/doi.org\/10.3390\/jcm13237275","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]}}}