{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:12Z","timestamp":1760146692325,"version":"build-2065373602"},"reference-count":5,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: As spontaneous renal artery dissection (SRAD) is a rare cause of abdominal pain, bilateral dissection is an extremely rare event. Only approximately two hundred cases of SRAD have been reported in the literature. The diagnosis is often delayed due to the rarity of the disease and non-specific clinical presentations such as flank pain, hypertension, fever, nausea, vomiting, and hematuria, which can be often misdiagnosed as a genito-urinary infection or gastrointestinal or bowel disease. Before 1980, the diagnosis of SRAD was mostly confirmed via autopsy or, rarely, via angiography. At present, the diagnosis is made using advanced imaging approaches, including computed tomography angiography (CTA) and magnetic resonance angiography (MRA), with a higher number of incidentally diagnosed SRADs. Methods: we performed laboratory tests and radiological examinations (computed abdominal tomography and multiplanar reconstruction) that revealed multiple infarctions and ischemic areas with hypoperfusion in the upper middle third of the left kidney and in a large part of middle and lower areas of the right kidney; the left renal artery exhibited increased intimal thickening and arteritis. Results: The multiplanar reconstruction revealed bilateral renal artery dissection and multiple arterial infarctions disseminated throughout both kidneys. After a clinical follow-up and hypertension retargeting, the patient was discharged with dual antiplatelet therapy and ACE inhibitor drugs. No lipid-lowering therapy was needed. Conclusions: Spontaneous renal artery dissection (SRAD) is a rare clinical event that typically presents with acute low-back or flank pain, hypertension, fever, hematuria, and acute renal failure. The condition could be misdiagnosed or receive a delayed diagnosis due to its relative rarity and non-specific presentation. The gold standard is enhanced computed tomography (CT) scans, and if the diagnosis is positive, vascular multiplanar reconstruction is generally suggested, as it can display lesions more clearly. Over 300 cases have been reported since the first characterization of SRAD; however, to date, a consensus has not been reached on the most appropriate treatment. Conservative therapy, open surgery, and intravascular intervention have been reported as treatments for SRAD.<\/jats:p>","DOI":"10.3390\/jcm13237307","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:48:56Z","timestamp":1733226536000},"page":"7307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple Renal Infarctions in Spontaneous Double Renal Artery Dissection: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-6983","authenticated-orcid":false,"given":"Gaetano","family":"Ferrara","sequence":"first","affiliation":[{"name":"Nephrology and Dialysis Unit, IRCCS Casa Sollievo Della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3317-9767","authenticated-orcid":false,"given":"Michelangelo","family":"Nasuto","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Fondazione IRCCS Casa Sollievo Della Sofferenza, 71013 San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, IRCCS Casa Sollievo Della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Ciccarese","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Fondazione IRCCS Casa Sollievo Della Sofferenza, 71013 San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-7049","authenticated-orcid":false,"given":"Filippo","family":"Aucella","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, IRCCS Casa Sollievo Della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"ref_1","first-page":"e6960","article-title":"Isolated renal artery dissection: A systematic review of case reports","volume":"12","author":"Jha","year":"2020","journal-title":"Cureus"},{"key":"ref_2","first-page":"337","article-title":"The radioanatomical research of plural renal arteries","volume":"60","author":"Vilhova","year":"2001","journal-title":"Folia Morphol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1538574417723155","article-title":"Endovascular treatment of spontaneous renal artery dissection after failure of medical management","volume":"51","author":"Vitiello","year":"2017","journal-title":"Vasc. Endovasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chamarthi, G., Koratala, A., and Ruchi, R. (2018). Spontaneous renal artery dissection masquerading as urinary tract infection. BMJ Case Rep., 2018.","DOI":"10.1136\/bcr-2018-226230"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1258\/ar.2012.110303","article-title":"Management of isolated non-traumatic renal artery dissection: Report of four cases","volume":"53","author":"Cassagnes","year":"2012","journal-title":"Acta Radiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/23\/7307\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:44:12Z","timestamp":1760114652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/23\/7307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":5,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13237307"],"URL":"https:\/\/doi.org\/10.3390\/jcm13237307","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,12,1]]}}}