{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:13:42Z","timestamp":1790820822660,"version":"4.1.0"},"reference-count":114,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The APC was funded by \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara.","award":["\/"],"award-info":[{"award-number":["\/"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>CT-guided transthoracic core-needle biopsy (CT-TTNB) is a minimally invasive procedure that plays a crucial role in diagnosing pulmonary nodules. With high diagnostic yield and low complication rates, CT-TTNB is favored over traditional surgical biopsies, providing accuracy in detecting both malignant and benign conditions. This literature review aims to present a comprehensive overview of CT-TTNB, focusing on its indications, procedural techniques, diagnostic yield, and safety considerations. Studies published between 2013 and 2024 were systematically reviewed from PubMed, Web of Science, Scopus, and Cochrane Library using the SANRA methodology. The results highlight that CT-TTNB has a diagnostic yield of 85\u201395% and sensitivity rates for detecting malignancies between 92 and 97%. Several factors, including nodule size, lesion depth, needle passes, and imaging techniques, influence diagnostic success. Complications such as pneumothorax and pulmonary hemorrhage were noted, with incidence rates varying from 12 to 45% for pneumothorax and 4 to 27% for hemorrhage. Preventative strategies and management algorithms are essential for minimizing and addressing these risks. In conclusion, CT-TTNB remains a reliable and effective method for diagnosing pulmonary nodules, particularly in peripheral lung lesions. Advancements such as PET\/CT fusion imaging, AI-assisted biopsy planning, and robotic systems further enhance precision and safety. This review emphasizes the importance of careful patient selection and procedural planning to maximize outcomes while minimizing risks, ensuring that CT-TTNB continues to be an indispensable tool in pulmonary diagnostics.<\/jats:p>","DOI":"10.3390\/jcm13237330","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:48:56Z","timestamp":1733226536000},"page":"7330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["CT-Guided Transthoracic Core-Needle Biopsy of Pulmonary Nodules: Current Practices, Efficacy, and Safety Considerations"],"prefix":"10.3390","volume":"13","author":[{"given":"Amalia","family":"Constantinescu","sequence":"first","affiliation":[{"name":"Doctoral School, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 6 No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-3340","authenticated-orcid":false,"given":"Emil Robert","family":"Stoicescu","sequence":"additional","affiliation":[{"name":"Radiology and Medical Imaging University Clinic, Department XV, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Research Center for Medical Communication, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Research Center for Pharmaco-Toxicological Evaluations, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-712X","authenticated-orcid":false,"given":"Roxana","family":"Iacob","sequence":"additional","affiliation":[{"name":"Research Center for Medical Communication, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"},{"name":"Department of Anatomy and Embryology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmin Alexandru","family":"Chira","sequence":"additional","affiliation":[{"name":"Doctoral School, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 6 No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2087-6848","authenticated-orcid":false,"given":"Daiana Marina","family":"Cocolea","sequence":"additional","affiliation":[{"name":"Doctoral School, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 6 No. 2, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin Ciprian","family":"Nicola","sequence":"additional","affiliation":[{"name":"Doctoral School, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 6 No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6237-939X","authenticated-orcid":false,"given":"Roxana","family":"Mladin","sequence":"additional","affiliation":[{"name":"Doctoral School, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 6 No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-0581","authenticated-orcid":false,"given":"Cristian","family":"Oancea","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, 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