{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:22:25Z","timestamp":1767979345276,"version":"3.49.0"},"reference-count":16,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: ST-segment elevation myocardial infarction (STEMI) remains a leading cause of mortality worldwide, primarily caused by acute thrombosis over atherosclerotic plaques. Simultaneous acute thrombosis in two coronary arteries is an exceptionally rare event. This report highlights a unique case of STEMI associated with cardiogenic shock due to dual coronary artery thrombosis and provides insights from a literature review on this rare condition. Methods: We report the case of a 58-year-old male with a history of hypertension, type II diabetes, and heavy smoking, who presented with a two-day history of chest pain and cardiogenic shock. Diagnostic evaluation included an electrocardiogram showing ST-segment elevation in AVR and ischemia, along with echocardiography revealing severe left ventricular dysfunction (ejection fraction 20%). Emergency coronary angiography was performed to identify the underlying pathology. Additionally, a literature review was conducted to analyze the characteristics and outcomes of similar cases of dual coronary artery thrombosis. Results: Coronary angiography identified significant occlusions in the proximal circumflex branch and the left anterior descending artery (LAD), a combination rarely reported in the literature. Our review confirmed that dual thrombosis involving the LAD and right coronary artery (RCA) is the most frequently described presentation of this condition, while simultaneous CFX and LAD thrombosis is exceedingly rare. Most reported cases, including ours, were associated with cardiogenic shock, highlighting the severity of this clinical entity. Despite successful thrombus aspiration and stenting, our patient experienced severe complications, including infections, pleural effusions, and paralytic ileus, ultimately requiring evaluation for left ventricular assist device implantation. Conclusions: This case underscores the complexity and critical challenges of managing STEMI with cardiogenic shock due to simultaneous coronary thrombosis. The findings from our literature review suggest the need for heightened clinical awareness and tailored revascularization strategies. Further studies are warranted to optimize management approaches and improve outcomes in such rare and high-risk scenarios.<\/jats:p>","DOI":"10.3390\/jcm13247511","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:17:20Z","timestamp":1733829440000},"page":"7511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A STEMI Complicated by Cardiogenic Shock Due to Simultaneous Acute Thrombosis of Two Coronary Vessels in the \u2018Deadly Double Infarct Syndrome\u2019: A Case Report and Discussion of Literature"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0925-1618","authenticated-orcid":false,"given":"Gianluca","family":"Guarnieri","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Mele","sequence":"additional","affiliation":[{"name":"Division of University Cardiology, IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Briguglia","sequence":"additional","affiliation":[{"name":"Division of University Cardiology, IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Medda","sequence":"additional","affiliation":[{"name":"Division of University Cardiology, IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-5788","authenticated-orcid":false,"given":"Edoardo","family":"Conte","sequence":"additional","affiliation":[{"name":"Division of University Cardiology, IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Bartorelli","sequence":"additional","affiliation":[{"name":"Division of University Cardiology, IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Andreini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, University of Milan, 20122 Milan, Italy"},{"name":"Division of University Cardiology, IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"bcr2015209941","DOI":"10.1136\/bcr-2015-209941","article-title":"Acute myocardial infarction due to simultaneous occlusions of the left anterior descending artery and right coronary artery","volume":"2015","author":"Edem","year":"2015","journal-title":"BMJ Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.amjcard.2009.04.053","article-title":"Multiple culprit arteries in patients with ST segment elevation myocardial infarction referred for primary percutaneous coronary intervention","volume":"104","author":"Pollak","year":"2009","journal-title":"Am. 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