{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:44:04Z","timestamp":1775324644656,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cerebral cavernous malformations (CCMs), particularly when located in the cerebellum, pose unique clinical challenges due to the risk of hemorrhage and proximity to critical neurovascular structures. Surgical resection is often necessary to prevent further neurological deterioration. This case report describes the management of a symptomatic cerebellar cavernoma, emphasizing the use of microsurgical techniques and long-term follow-up. The objective of this study is to illustrate the surgical approach and outcomes of a patient with a hemorrhagic cerebellar cavernoma. Methods: A 63-year-old female presented with vertigo, and neuroimaging revealed a hemorrhagic cavernous malformation located in the right cerebellar hemisphere. Follow-up was conducted at two months and one year postoperatively, with serial imaging to assess lesion recurrence and neurological recovery. Results: Complete resection of the cavernoma was achieved without postoperative neurological deficits. Imaging at two months and one year post-surgery showed no signs of recurrence or new lesion formation. The patient remained asymptomatic, with no cranial nerve deficits or other long-term complications. Conclusions: This case demonstrates the effectiveness of microsurgical resection in treating symptomatic cerebellar cavernomas. The use of advanced intraoperative tools, such as neuronavigation and IONM, contributed to the successful outcome and prevention of postoperative complications. Long-term follow-up remains crucial to monitor for recurrence or the development of de novo lesions.<\/jats:p>","DOI":"10.3390\/jcm13247525","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T06:44:05Z","timestamp":1733899445000},"page":"7525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cerebellar Cavernoma Resection: Case Report with Long-Term Follow-Up"],"prefix":"10.3390","volume":"13","author":[{"given":"Corneliu","family":"Toader","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matei","family":"Serban","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan-Adrian","family":"Covache-Busuioc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugurel Petrinel","family":"Radoi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghaith Saleh Radi","family":"Aljboor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-9958","authenticated-orcid":false,"given":"Horia Petre","family":"Costin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9232-1176","authenticated-orcid":false,"given":"Antonio Daniel","family":"Corlatescu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca-Andrei","family":"Glavan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu Mircea","family":"Gorgan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Neurosurgery, Clinical Emergency Hospital \u201cBagdasar-Arseni\u201d, 041915 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3171\/2016.3.JNS152419","article-title":"Hemorrhage from cerebral cavernous malformations: A systematic pooled analysis","volume":"126","author":"Gross","year":"2017","journal-title":"J. Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Coppola, F., L\u00f6bel, U., Morana, G., Reddy, N., and Mankad, K. (2024). Tumour mimics in paediatric neuroimaging. Neuroradiology.","DOI":"10.1007\/s00234-024-03507-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3174\/ajnr.A7771","article-title":"Diagnostic Accuracy of Arterial Spin-Labeling, Dynamic Contrast-Enhanced, and DSC Perfusion Imaging in the Diagnosis of Recurrent High-Grade Gliomas: A Prospective Study","volume":"44","author":"Nguyen","year":"2023","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1227\/00006123-199604000-00006","article-title":"Growth, subsequent bleeding, and de novo appearance of cerebral cavernous angiomas","volume":"38","author":"Pozzati","year":"1996","journal-title":"Neurosurgery"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.wneu.2015.05.062","article-title":"Surgical Treatment of Cerebellar Cavernous Malformations: A Single-Center Experience with 58 Cases","volume":"84","author":"Wu","year":"2015","journal-title":"World Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1212\/WNL.0b013e318248de9b","article-title":"Prospective hemorrhage risk of intracerebral cavernous malformations","volume":"78","author":"Flemming","year":"2012","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7461\/jcen.2017.19.1.19","article-title":"Surgical Approaches for Symptomatic Cerebral Cavernous Malformations of the Thalamus and Brainstem","volume":"19","author":"Ding","year":"2017","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.23736\/S0390-5616.21.05433-3","article-title":"An international call for a new grading system for cerebral and cerebellar cavernomas","volume":"65","author":"Fontanella","year":"2021","journal-title":"J. Neurosurg. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e597","DOI":"10.1016\/j.wneu.2022.03.070","article-title":"Preliminary Validation of FoRCaSco: A New Grading System for Cerebral and Cerebellar Cavernomas","volume":"162","author":"Fontanella","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tatagiba, M., Lepski, G., Kullmann, M., Krischek, B., Danz, S., Bornemann, A., Klein, J., Fahrig, A., Velnar, T., and Feigl, G.C. (2023). The Brainstem Cavernoma Case Series: A Formula for Surgery and Surgical Technique. Medicina, 59.","DOI":"10.3390\/medicina59091601"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4103\/0976-3147.178674","article-title":"Giant cavernous malformations","volume":"7","author":"Linsler","year":"2016","journal-title":"J. Neurosci. Rural. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1474-4422(15)00303-8","article-title":"Clinical course of untreated cerebral cavernous malformations: A meta-analysis of individual patient data","volume":"15","author":"Horne","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"De Simone, M., Fontanella, M.M., Choucha, A., Schaller, K., Machi, P., Lanzino, G., Bijlenga, P., Kurz, F.T., L\u00f6vblad, K.-O., and De Maria, L. (2024). Current and Future Applications of Arterial Spin Labeling MRI in Cerebral Arteriovenous Malformations. Biomedicines, 12.","DOI":"10.3390\/biomedicines12040753"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.52662\/jksfn.2022.00255","article-title":"Radiosurgery for cerebral cavernous malformations","volume":"18","author":"Cho","year":"2022","journal-title":"J. Korean Soc. Ster. Func. Neurosurg."},{"key":"ref_15","first-page":"e560","article-title":"Dural-Based Cavernoma of the Posterior Cranial Fossa Mimicking a Meningioma: A Case Report","volume":"8","author":"Cruz","year":"2016","journal-title":"Cureus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2019.3.JNS181724","article-title":"Cavernous angiomas: Deconstructing a neurosurgical disease","volume":"131","author":"Awad","year":"2019","journal-title":"J. Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1007\/s00701-023-05815-z","article-title":"Impact of tailored multimodal treatment for unruptured brain arteriovenous malformation: Comparison with a randomized trial of unruptured brain arteriovenous malformations","volume":"165","author":"Ikedo","year":"2023","journal-title":"Acta Neurochir."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/ons\/opz294","article-title":"Cavernous Malformations in and Around the Third Ventricle: Indications, Approaches, and Outcomes","volume":"18","author":"Woodall","year":"2020","journal-title":"Oper. Neurosurg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nm.1911","article-title":"The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases","volume":"15","author":"Whitehead","year":"2009","journal-title":"Nat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature22075","article-title":"Endothelial TLR4 and the microbiome drive cerebral cavernous malformations","volume":"545","author":"Tang","year":"2017","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12967-022-03360-4","article-title":"Propranolol as therapy for cerebral cavernous malformations: A cautionary note","volume":"20","author":"Shenkar","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/STROKEAHA.111.625467","article-title":"Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease","volume":"43","author":"McDonald","year":"2012","journal-title":"Stroke"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Alicandri-Ciufelli, M., Molinari, G., D\u2019Alessandro, E., Nocini, R., Presutti, L., and Marchioni, D. (2024). Endoscopic Ear Surgery, from the Last Ten to the Next Ten Years: A Critical Perspective. J. Clin. Med., 13.","DOI":"10.3390\/jcm13216300"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"De Simone, M., Zoia, C., Choucha, A., Kong, D.-S., and De Maria, L. (2024). The Transorbital Approach: A Comprehensive Review of Targets, Surgical Techniques, and Multiportal Variants. J. Clin. Med., 13.","DOI":"10.3390\/jcm13092712"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10143-019-01188-z","article-title":"International expert consensus statement about methods and indications for keyhole microneurosurgery from International Society on Minimally Invasive Neurosurgery","volume":"44","author":"Lan","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s43163-024-00657-7","article-title":"Patient satisfaction with endoscopic ear surgery technique: A comparative study with the postauricular incision microscopic technique","volume":"40","author":"Metwaly","year":"2024","journal-title":"Egypt. J. Otolaryngol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Harapan, B.N., Ruf, V., Herms, J., Forbrig, R., Schichor, C., and Thorsteinsdottir, J. (2024). Cerebellar Venous Hemangioma: Two Case Reports and Literature Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13195813"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7525\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:52:09Z","timestamp":1760115129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":27,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13247525"],"URL":"https:\/\/doi.org\/10.3390\/jcm13247525","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}