{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:09:48Z","timestamp":1792177788046,"version":"4.4.0"},"reference-count":27,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Renal replacement therapy with an oXiris hemofilter may be helpful for patients with acute kidney injury in conjunction with sepsis and septic shock. The aim of this study was to assess the impact of an oXiris membrane on septic shock patients. Methods: All renal replacement therapies with oXiris (Baxter, Deerfield, IL, USA) performed between January 2018 and August 2021 were retrospectively analyzed. CRRT was initiated in continuous venovenous hemodiafiltration (CVVHDF) mode using Prismaflex System (Baxter). Demographic data, starting point of infection, source control, etiology, and course of treatment were analyzed. Results: A total of 32 patients were included in the study. Most patients treated with oXiris had acute kidney injury (AKI) and required CRRT. One patient had KDIGO 1 AKI (3.1%), three patients (9.4%) had KDIGO 2 AKI, and 28 patients (87.5%) had KDIGO 3 AKI. A statistically significant decrease in vasopressin dosage was required to achieve adequate MAP after 24 and 72 h, and a statistically significant decrease in norepinephrine dosage after 72 h was observed, with no SOFA score change on days 2 and 3. Procalcitonin and lactate levels did not change after 24 and 72 h. No beneficial effect on mortality was observed. Conclusions: Treatment with an oXiris membrane can positively impact vasopressors\u2019 requirement but not influence SOFA score, procalcitonin or lactate levels, or mortality in septic shock patients.<\/jats:p>","DOI":"10.3390\/jcm13247527","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T06:44:05Z","timestamp":1733899445000},"page":"7527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does Continuous Renal Replacement Therapy with oXiris in Septic Shock Have Any Positive Impact? Single-Centre Experience with oXiris Therapy in Septic Shock Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Wojciech","family":"Mielnicki","sequence":"first","affiliation":[{"name":"Anestesiology and Intensive Care Ward, Olawa District Hospital, 55-200 Olawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1483-0449","authenticated-orcid":false,"given":"Agnieszka","family":"Dyla","sequence":"additional","affiliation":[{"name":"Anestesiology and Intensive Care Ward, Olawa District Hospital, 55-200 Olawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Zaj\u0105c","sequence":"additional","affiliation":[{"name":"Anestesiology and Intensive Care Ward, Olawa District Hospital, 55-200 Olawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Rokicka-Demitraszek","sequence":"additional","affiliation":[{"name":"Anestesiology and Intensive Care Ward, Olawa District Hospital, 55-200 Olawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-4796","authenticated-orcid":false,"given":"Jacek","family":"Smereka","sequence":"additional","affiliation":[{"name":"Department of Emergency Medical Service, Wroclaw Medical University, 51-616 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1097\/CCM.0000000000003342","article-title":"Epidemiology and Costs of Sepsis in the United States\u2014An Analysis Based on Timing of Diagnosis and Severity Level","volume":"46","author":"Paoli","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13613-023-01224-8","article-title":"Effects of enhanced adsorption haemofiltration versus haemoadsorption in severe, refractory septic shock with high levels of endotoxemia: The ENDoX bicentric, randomized, controlled trial","volume":"13","author":"Eberle","year":"2023","journal-title":"Ann. Intensive Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/epidemiologia5030032","article-title":"The Global Burden of Sepsis and Septic Shock","volume":"5","author":"Sangiorgio","year":"2024","journal-title":"Epidemiologia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13054-020-02950-2","article-title":"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019\u2014Results from a systematic review and meta-analysis","volume":"24","author":"Bauer","year":"2020","journal-title":"Crit. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000\u20132012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrneph.2017.165","article-title":"Advances in the understanding and treatment of sepsis-induced immunosuppression","volume":"14","author":"Venet","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00134-017-4755-7","article-title":"Acute kidney injury in sepsis","volume":"43","author":"Bellomo","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1001\/jama.2009.856","article-title":"Early use of polymyxin B hemoperfusion in abdominal septic shock: The EUPHAS randomized controlled trial","volume":"301","author":"Cruz","year":"2009","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000499510","article-title":"oXiris\u00ae Use in Septic Shock: Experience of Two French Centres","volume":"47","author":"Schwindenhammer","year":"2019","journal-title":"Blood Purif."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Li, Y., Sun, P., Chang, K., Yang, M., Deng, N., Chen, S., and Su, B. (2022). Effect of Continuous Renal Replacement Therapy with the oXiris Hemofilter on Critically Ill Patients: A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11226719"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jama.2018.14618","article-title":"Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients with Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial","volume":"320","author":"Dellinger","year":"2018","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sch\u00e4dler, D., Pausch, C., Heise, D., Meier-Hellmann, A., Brederlau, J., Weiler, N., Marx, G., Putensen, C., Spies, C., and J\u00f6rres, A. (2017). The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: A randomized controlled trial. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187015"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40635-018-0177-2","article-title":"In vitro comparison of the adsorption of inflammatory mediators by blood purification devices","volume":"6","author":"Malard","year":"2018","journal-title":"Intensive Care Med. Exp."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000499589","article-title":"Continuous Renal Replacement Therapy with the Adsorbing Filter oXiris in Septic Patients: A Case Series","volume":"47","author":"Turani","year":"2019","journal-title":"Blood Purif."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Broman, M.E., Hansson, F., Vincent, J.-L., and Bodelsson, M. (2019). Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: A randomized crossover double-blind study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220444"},{"key":"ref_18","first-page":"2317","article-title":"Application of Different Continuous Renal Replacement Therapy Hemofilter in Patients with Septic Shock Complicated with Acute Renal Injury","volume":"51","author":"Liu","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Wu, C., Ouyang, L., Peng, Y., Zhong, D., Xiang, X., and Li, J. (2022). Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.1012998"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/03913988221107947","article-title":"Effect of CRRT with oXiris filter on hemodynamic instability in surgical septic shock with AKI: A pilot randomized controlled trial","volume":"45","author":"Feng","year":"2022","journal-title":"Int. J. Artif. Organs"},{"key":"ref_21","first-page":"491","article-title":"Application of endotoxin and cytokine adsorption haemofilter in septic acute kidney injury due to Gram-negative bacterial infection","volume":"19","author":"Shum","year":"2013","journal-title":"Hong Kong Med. J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Guan, M., Wang, H., Tang, X., Zhao, Y., Wang, F., Zhang, L., and Fu, P. (2022). Continuous Renal Replacement Therapy with Adsorbing Filter oXiris in Acute Kidney Injury with Septic Shock: A Retrospective Observational Study. Front. Med., 9.","DOI":"10.3389\/fmed.2022.789623"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1159\/000524088","article-title":"Effect of oXiris-CVVH on the Clinical Outcomes of Patients with Septic Shock: An Inverse Probability of Treatment-Weighted Analysis","volume":"51","author":"Xie","year":"2022","journal-title":"Blood Purif."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"154844","DOI":"10.1016\/j.jcrc.2024.154844","article-title":"Outcomes of extracorporeal blood purification with oXiris\u00ae membrane in critically ill patients: A systematic review and meta-analysis","volume":"83","author":"Siew","year":"2024","journal-title":"J. Crit. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s13054-023-04555-x","article-title":"Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: A systematic review and meta-analysis","volume":"27","author":"Wang","year":"2023","journal-title":"Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/sdi.12496","article-title":"We Underdose Antibiotics in Patients on CRRT","volume":"29","author":"Shaw","year":"2016","journal-title":"Semin. Dial."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000499633","article-title":"Augmented Adsorptive Blood Purification during Continuous Veno-Venous Haemodiafiltration in a Severe Septic, Acute Kidney Injury Patient: Use of oXiris\u00ae: A Single Centre Case Report","volume":"47","author":"Tan","year":"2019","journal-title":"Blood Purif."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:52:10Z","timestamp":1760115130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":27,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13247527"],"URL":"https:\/\/doi.org\/10.3390\/jcm13247527","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}