{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:37:04Z","timestamp":1780634224561,"version":"3.54.1"},"reference-count":48,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Elderly populations are under-represented in inflammatory bowel disease (IBD) clinical trials, with limited data on phenotype, treatment patterns, outcomes, and comorbidities. The main objective of this study was to evaluate, in an elderly cohort with IBD, demographic and disease characteristics, comorbidity, polypharmacy, and treatment patterns according to the development of IBD at or before old age. Secondarily, the same analysis was performed based on the type of IBD: ulcerative colitis (UC) or Crohn\u2019s disease (CD). Materials and Methods: Observational, single-center, retrospective study including patients diagnosed with IBD and aged 65 years or older seen at the IBD office of the Regional University Hospital of Malaga between September and November 2022. Data were recorded on demographic, disease-related, and IBD treatment-related variables, comorbidities, and polypharmacy. A descriptive and analytical study was undertaken according to the age of IBD onset and type of IBD. Results: Of the patients included, 50.8% were male, 55.1% had CD, and 44.9% UC. IBD onset was before age 65 years in 69.5% and \u226565 years in 30.5%. Elderly with IBD who debuted &lt;65 presented longer disease duration (19.67 \u00b1 9.82 years) and required more IBD-related surgeries (37.8%); elderly with IBD who debuted \u226565 were older (77.69 \u00b1 6.26 years), with no differences in the other variables. According to the type of IBD, elderly UC patients were older (74.55 \u00b1 6.9 years), used more aminosalicylates (77.4%), and had higher rates of polypharmacy (90.6%). Elderly patients with CD had higher IBD activity (moderate\/severe in 72.3%), used more biologic drugs (58.5%), and required more IBD-related surgeries (44.6%). Conclusions: Elderly patients who develop IBD before or after the age of 65 years are overall very similar in baseline and disease-related characteristics. Elderly with CD have higher IBD activity and require more biologic drugs and IBD-related surgeries. Elderly with UC are older and have higher rates of polypharmacy and aminosalicylate use.<\/jats:p>","DOI":"10.3390\/jcm13247581","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:55:45Z","timestamp":1734069345000},"page":"7581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Inflammatory Bowel Disease in the Elderly According to Age of Onset"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-9572","authenticated-orcid":false,"given":"Manuel Bracho","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"UGC de Aparato Digestivo, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Plataforma BIONAD, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal Vicente","family":"Olmedo Mart\u00edn","sequence":"additional","affiliation":[{"name":"UGC de Aparato Digestivo, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Plataforma BIONAD, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3825-9680","authenticated-orcid":false,"given":"Ana Isabel","family":"Morales Berm\u00fadez","sequence":"additional","affiliation":[{"name":"UGC de Aparato Digestivo, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Plataforma BIONAD, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-1019","authenticated-orcid":false,"given":"Miguel","family":"Jim\u00e9nez P\u00e9rez","sequence":"additional","affiliation":[{"name":"UGC de Aparato Digestivo, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Plataforma BIONAD, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.pop.2023.03.009","article-title":"Inflammatory Bowel Disease","volume":"50","author":"Bruner","year":"2023","journal-title":"Prim Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/archdischild-2023-325668","article-title":"Inflammatory bowel disease: Recent developments","volume":"109","author":"Ashton","year":"2024","journal-title":"Arch. Dis. Child."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/jebm.12626","article-title":"Diagnosis and management of inflammatory bowel disease","volume":"17","author":"Li","year":"2024","journal-title":"J. Evid. Based Med."},{"key":"ref_4","unstructured":"Mogoll\u00f3n, F., Hinojosa, J., and Gassull, M.A. (2019). Definiciones y clasificaci\u00f3n. Enfermedad Inflamatoria Intestinal, Ergon. [4th ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/ecco-jcc\/jjad142","article-title":"Definitions of Histological Abnormalities in Inflammatory Bowel Disease: An ECCO Position Paper","volume":"18","author":"Feakins","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Cos\u00edn-Roger, J. (2024). Inflammatory Bowel Disease: Immune Function, Tissue Fibrosis and Current Therapies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126416"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","article-title":"Environmental triggers in IBD: A review of progress and evidence","volume":"15","author":"Ananthakrishnan","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7247238","DOI":"10.1155\/2019\/7247238","article-title":"A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11894-017-0562-0","article-title":"Modifiable Environmental Factors in Inflammatory Bowel Disease","volume":"19","author":"Burke","year":"2017","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.rmclc.2019.06.003","article-title":"Epidemiolog\u00eda de la enfermedad inflamatoria intestinal","volume":"30","author":"Figueroa","year":"2019","journal-title":"Revista M\u00e9dica Cl\u00ednica Las Condes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_14","first-page":"263","article-title":"European Crohn\u2019s and Colitis Organisation Topical Review on IBD in the Elderly","volume":"11","author":"Sturm","year":"2017","journal-title":"J. Crohns Colitis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/MIB.0000000000000738","article-title":"Epidemiology and Long-term Outcome of Inflammatory Bowel Disease Diagnosed at Elderly Age-An Increasing Distinct Entity?","volume":"22","author":"Jeuring","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/MIB.0000000000000306","article-title":"Health Care utilization in elderly onset inflammatory bowel disease: A population-based study","volume":"21","author":"Nguyen","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/ecco-jcc\/jjv059","article-title":"Inflammatory bowel disease and the elderly: A review","volume":"9","author":"Taleban","year":"2015","journal-title":"J. Crohns Colitis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ecco-jcc\/jjw054","article-title":"Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease","volume":"10","author":"Ananthakrishnan","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.dld.2022.12.024","article-title":"Management of inflammatory bowel disease in the elderly: A review","volume":"55","author":"Sousa","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/ajg.2012.218","article-title":"Serious infection and mortality in patients with Crohn\u2019s disease: More than 5 years of follow-up in the TREAT\u2122 registry","volume":"107","author":"Lichtenstein","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1111\/j.1572-0241.2008.02052.x","article-title":"Rising prevalence of venous thromboembolism and its impact on mortality among hospitalized inflammatory bowel disease patients","volume":"103","author":"Nguyen","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ibd.20628","article-title":"Inflammatory bowel disease in the elderly is associated with worse outcomes: A national study of hospitalizations","volume":"15","author":"Ananthakrishnan","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1053\/j.gastro.2008.01.004","article-title":"Impact of hospital volume on postoperative morbidity and mortality following a colectomy for ulcerative colitis","volume":"134","author":"Kaplan","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jcsm.13341","article-title":"Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study","volume":"14","author":"Zhang","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.annepidem.2023.10.006","article-title":"Frailty and pre-frailty with long-term risk of elderly-onset inflammatory bowel disease: A large-scale prospective cohort study","volume":"88","author":"Zhang","year":"2023","journal-title":"Ann. Epidemiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"502203","DOI":"10.1016\/j.gastrohep.2024.502203","article-title":"Profiling the patient with inflammatory bowel disease in the relationship between physical activity and partner\/social network status: A post hoc patient-tailored analysis of the \u201cBE-FIT-IBD\u201d study","volume":"8","author":"Gravina","year":"2024","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/gastroent15040067","article-title":"Too Many Couch Potatoes Among Middle-Aged Inflammatory Bowel Disease Patients: Findings from the \u201cBE-FIT-IBD-2\u201d Study","volume":"15","author":"Gravina","year":"2024","journal-title":"Gastroenterol. Insights"},{"key":"ref_28","first-page":"1392","article-title":"Older age and steroid use are associated with increasing polypharmacy and potential medication interactions among patients with inflammatory bowel disease","volume":"21","author":"Parian","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1007\/s10620-012-2083-x","article-title":"Geriatric inflammatory bowel disease: Phenotypic presentation, treatment patterns, nutritional status, outcomes, and comorbidity","volume":"57","author":"Juneja","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.crohns.2012.09.001","article-title":"International variation in medication prescription rates among elderly patients with inflammatory bowel disease","volume":"7","author":"Benchimol","year":"2013","journal-title":"J. Crohns Colitis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/gutjnl-2012-303864","article-title":"Natural history of elderly-onset inflammatory bowel disease: A population-based cohort study","volume":"63","author":"Charpentier","year":"2014","journal-title":"Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000521288","article-title":"Charlson Comorbidity Index: A Critical Review of Clinimetric Properties","volume":"91","author":"Charlson","year":"2022","journal-title":"Psychother. Psychosom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1097\/MCG.0000000000001647","article-title":"Polypharmacy in Patients With Inflammatory Bowel Disease: Prevalence and Outcomes in a Single-center Series","volume":"56","author":"Mesonero","year":"2022","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Masnoon, N., Shakib, S., Kalisch-Ellett, L., and Caughey, G.E. (2017). What is polypharmacy? A systematic review of definitions. BMC Geriatr., 17.","DOI":"10.1186\/s12877-017-0621-2"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/j.gastro.2020.08.060","article-title":"AGA Clinical Practice Update on Management of Inflammatory Bowel Disease in Elderly Patients: Expert Review","volume":"160","author":"Ananthakrishnan","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cgh.2010.09.026","article-title":"Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease","volume":"9","author":"Cottone","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1053\/j.gastro.2013.07.035","article-title":"Risk of lymphoma in patients with ulcerative colitis treated with thiopurines: A nationwide retrospective cohort study","volume":"145","author":"Khan","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/ajg.2013.451","article-title":"Association between thiopurine use and nonmelanoma skin cancers in patients with inflammatory bowel disease: A meta-analysis","volume":"109","author":"Ariyaratnam","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1053\/j.gastro.2012.05.004","article-title":"Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease","volume":"143","author":"Long","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/apt.13294","article-title":"Efficacy and safety of anti-TNF therapy in elderly patients with inflammatory bowel disease","volume":"42","author":"Ferrante","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/apt.15821","article-title":"Frailty is independently associated with mortality in 11 001 patients with inflammatory bowel diseases","volume":"52","author":"Kochar","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s11938-020-00310-1","article-title":"Incorporating Frailty in the Treatment Program of Elderly Patients with Gastrointestinal Disease","volume":"18","author":"Thompson","year":"2020","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/00365520802600961","article-title":"Clinical course during the first 10 years of ulcerative colitis: Results from a population-based inception cohort (IBSEN Study)","volume":"44","author":"Solberg","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"h2809","DOI":"10.1136\/bmj.h2809","article-title":"Association between tumour necrosis factor-\u03b1 inhibitors and risk of serious infections in people with inflammatory bowel disease: Nationwide Danish cohort study","volume":"350","author":"Pasternak","year":"2015","journal-title":"BMJ"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/ibd\/izaa308","article-title":"Disease- and Treatment-related Complications in Older Patients With Inflammatory Bowel Diseases: Comparison of Adult-onset vs Elderly-onset Disease","volume":"27","author":"Rozich","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/archsurg.2011.194","article-title":"Risk of comorbidities on postoperative outcomes in patients with inflammatory bowel disease","volume":"146","author":"Kaplan","year":"2011","journal-title":"Arch. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/MIB.0000000000000993","article-title":"Risk of Surgery and Mortality in Elderly-onset Inflammatory Bowel Disease: A Population-based Cohort Study","volume":"23","author":"Nguyen","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/j.gastro.2017.10.034","article-title":"Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden","volume":"154","author":"Everhov","year":"2018","journal-title":"Gastroenterology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7581\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:54:04Z","timestamp":1760115244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,13]]},"references-count":48,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13247581"],"URL":"https:\/\/doi.org\/10.3390\/jcm13247581","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,13]]}}}