{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:33:30Z","timestamp":1772163210385,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council Clinician Scientist Fellowship","award":["MR\/P008348\/1"],"award-info":[{"award-number":["MR\/P008348\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Excessive alcohol consumption is among the leading causes of hospitalisation in high-income countries and contributes to over 200 medical conditions. We aimed to determine the prevalence and characteristics of alcohol use disorder (AUD), describe the distribution of AUD in ICD-10 discharge diagnosis groups and ascertain any relationship between them in secondary care. Methods: The study group was a retrospective cohort of adult patients admitted to Nottingham University Hospital (NUH) between 4 April 2009 and 31 March 2020. Uni- and multivariable analysis was performed to determine the relationship between AUD and covariable high-risk characteristics and describe the distribution of AUD in ICD-10 discharge diagnosis groups defined by an alcohol-attributable fraction. Results: A total of 44,804 patients (66,440 admissions) were included, with a mean age of 63.1 years (SD \u00b1 19.9); of these, 48.0% (n = 20,863) were male and 71.2% were (n = 30,994) white. AUDIT-C was completed in 97.1% (n = 43,514) of patients, and identified 16.5% (n = 7164) as having AUD, while 2.1% (n = 900) were found to be alcohol-dependent. In patients with AUD, 4.0% (n = 283) had an ICD-10 diagnosis that was alcohol-specific and 17.5% (n = 1255) were diagnosed with alcohol-related disorders; the remainder were not diagnosed with either disorder. Two-thirds (64.7%) of the patients with AUD had associated mental and behavioural disorders. Multivariable logistic regression analysis revealed that patients aged 60\u201369 had the highest risk of AUD (OR 4.19, 95% CI 3.53\u20134.99). Being single (OR 1.18, 95% CI 1.11\u20131.26) and a history of emergency admission (OR 1.21, 95% CI 1.14\u20131.29) were associated with increased odds of AUD. Conversely, females compared to males (OR 0.34, 95% CI 0.35\u20130.39), individuals from minority ethnic backgrounds compared to white Caucasians (OR 0.39, 95% CI 0.35\u20130.45), and those from more deprived areas (IMD quintile 1: OR 0.79, 95% CI 0.74\u20130.86) had lower odds of AUD. Conclusions: One in six admitted patients had AUD, with a higher risk in males, ages 60\u201369, and emergency admissions. Mental disorders are highly prevalent among hospitalised patients with AUD. The performance of the AUDIT-C score varied among hospitalised patients based on their ICD-10 diagnosis, which should be considered when implementing universal alcohol screening in these settings.<\/jats:p>","DOI":"10.3390\/jcm13247617","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T12:09:28Z","timestamp":1734350968000},"page":"7617","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening for Alcohol Use Disorder Among Hospitalised Patients: Learning from a Retrospective Cohort Study in Secondary Care"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-7263","authenticated-orcid":false,"given":"Mohsan","family":"Subhani","sequence":"first","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Nottingham NG7 2GT, UK"},{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipaka Rani","family":"Nath","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-1339","authenticated-orcid":false,"given":"Usman","family":"Talat","sequence":"additional","affiliation":[{"name":"Dyson School of Design Engineering, Imperial College London, London SW72BX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aqsa","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"School of Medicine, Fatima Jinnah Medical University, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amardeep","family":"Khanna","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awais","family":"Ali","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-4830","authenticated-orcid":false,"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Nottingham NG7 2GT, UK"},{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-4444","authenticated-orcid":false,"given":"Stephen D.","family":"Ryder","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Nottingham NG7 2GT, UK"},{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne R.","family":"Morling","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Nottingham NG7 2GT, UK"},{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2GT, UK"},{"name":"Division of Epidemiology and Public Health, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"ref_1","unstructured":"NHS-Digital (2024, March 01). 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