{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:52:41Z","timestamp":1787730761486,"version":"build-2784847793"},"reference-count":18,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: The objective of this study was to evaluate the impact of diabetes mellitus (DM) on the outcome of Schlemm\u2019s canal-based minimally invasive glaucoma surgery (MIGS). Methods: In a retrospective interventional cohort study, postoperative intraocular pressure (IOP) and intracameral bleeding were analyzed in 25 diabetic patients and 84 non-diabetic patients, with primary open-angle glaucoma (POAG) or ocular hypertension (OH). Results: The mean follow-up period for all 109 eyes was 35.3 \u00b1 24.8 months. There was no significant difference in preoperative IOP between cohorts with or without diabetes. However, the post-surgical IOP between 3 months and 2 years was significantly higher in the cohort with diabetes (p = 0.019 to 0.001). The 3-year survival probability of achieving an IOP \u2264 15 mmHg was 17.8 \u00b1 0.09% in patients with diabetes, significantly lower than the 30.4 \u00b1 0.06% observed in patients without diabetes (p = 0.042 Log-rank test). The 3-year survival probability of achieving an IOP \u2264 18 mmHg was 56.7 \u00b1 0.12% in patients with diabetes compared to 79.5 \u00b1 0.05% in patients without diabetes, indicating a marginally significant difference between cohorts with and without diabetes (p = 0.065). When the random effect of diabetes mellitus (DM) was analyzed alongside the fixed effects of preoperative IOP, age, refractive error, and the extent of canal opening using a multivariate linear mixed model, DM emerged as a significant risk factor for higher postoperative IOP at both 6 and 12 months (p &lt; 0.001). Conclusions: Diabetes mellitus is a significant risk factor for poor outcomes following Schlemm\u2019s canal-based MIGS, particularly in achieving lower postoperative IOP.<\/jats:p>","DOI":"10.3390\/jcm13247660","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:46:02Z","timestamp":1734407162000},"page":"7660","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diabetes Mellitus: A Risk Factor in Schlemm\u2019s Canal-Based Minimally Invasive Glaucoma Surgery"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-9968","authenticated-orcid":false,"given":"Etsuo","family":"Chihara","sequence":"first","affiliation":[{"name":"Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Kyoto 611-0043, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-1767","authenticated-orcid":false,"given":"Eri","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 611-0043, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Chihara","sequence":"additional","affiliation":[{"name":"Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Kyoto 611-0043, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.ophtha.2004.12.043","article-title":"Clinical results with the Trabectome for treatment of open-angle glaucoma","volume":"112","author":"Minckler","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ajo.2012.09.023","article-title":"Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device","volume":"155","author":"Seibold","year":"2013","journal-title":"Am. 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