{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:53Z","timestamp":1787028653493,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union Recovery and Resilience Mechanism Plan and the state budget funded project \u201cRSU internal and RSU with LASE external consolidation\u201d","award":["Nr.5.2.1.1.i.0\/2\/24\/I\/CFLA\/005"],"award-info":[{"award-number":["Nr.5.2.1.1.i.0\/2\/24\/I\/CFLA\/005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Cardiopulmonary bypass can lead to hemodilution, causing a fluid shift to the interstitial space. Albumin helps counteract the intravascular fluid movement to the extravascular space and reduces the risk of complications associated with fluid imbalance. Our main objective was to evaluate the effectiveness of albumin addition in the cardiopulmonary bypass priming solution compared to standard priming, focusing on its role in reducing pleural effusion development. Methods: This was a single-center randomized controlled trial conducted at a tertiary care hospital specializing in cardiology and cardiac surgery. It involved 70 individuals scheduled for elective open-heart surgery. All cases were randomly assigned into two groups of 35 patients. The study group replaced 100 mL of standard CPB priming solution with 100 mL of 20% human albumin. We measured serum albumin levels before and after the surgery, 6 and 12 h after, and calculated colloid oncotic pressure. Thorax CT scans were performed on the first postoperative day to measure and calculate pleural effusion volume. Results: Albumin addition to cardiopulmonary bypass priming solution led to a significant reduction in pleural effusion development after CPB. An albumin level &lt;35 g\/L after the surgery showed a significant increase in pleural effusion development, and 100 mL of 20% albumin was sufficient to maintain serum albumin levels &gt; 35 g\/L. Conclusions: Our study suggests a link between postoperative hypoalbuminemia and the early development of pleural effusion after CPB, as well as the possible benefits of adding 100 mL of 20% albumin compared to standard crystalloid CPB priming to minimize postoperative pleural effusion development.<\/jats:p>","DOI":"10.3390\/jcm13247693","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:26:02Z","timestamp":1734413162000},"page":"7693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Randomized Controlled Trial on the Efficacy of 20% Human Albumin in Reducing Pleural Effusion After Cardiopulmonary Bypass"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-4755","authenticated-orcid":false,"given":"Kaspars","family":"Setlers","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Anesthesia and Intensive Care, Pauls Stradins Clinical University Hospital, LV-1002 Riga, Latvia"},{"name":"Department of Anesthesiology, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudija","family":"Aispure","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-5869","authenticated-orcid":false,"given":"Maksims","family":"Zolovs","sequence":"additional","affiliation":[{"name":"Statistics Unit, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Institute of Life Sciences and Technology, Daugavpils University, LV-5401 Daugavpils, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligita","family":"Zvaigzne","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Pauls Stradins Clinical University Hospital, LV-1002 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olegs","family":"Sabelnikovs","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Department of Intensive Care, Pauls Stradins Clinical University Hospital, LV-1002 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-6136","authenticated-orcid":false,"given":"Peteris","family":"Stradins","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Pauls Stradins Clinical University Hospital, LV-1002 Riga, Latvia"},{"name":"Department of Surgery, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1453-871X","authenticated-orcid":false,"given":"Eva","family":"Strike","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Anesthesia and Intensive Care, Pauls Stradins Clinical University Hospital, LV-1002 Riga, Latvia"},{"name":"Department of Anesthesiology, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bpa.2015.04.002","article-title":"Pulmonary complications of cardiopulmonary bypass","volume":"29","author":"Huffmyer","year":"2015","journal-title":"Best Pract. 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