{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:05:11Z","timestamp":1787828711495,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"iSTAR Medical"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study compares the long-term intraocular pressure (IOP)-lowering efficacy of standalone MINIject (iSTAR Medical, Belgium) suprachoroidal implantation and two iStent (Glaukos, CA, USA) trabecular bypass implantation using a systematic review and meta-analysis. Methods: Systematic review of standalone implantation of MINIject or iStent inject with at least 24 months of follow up. The mean and standard deviation of IOP and the number of IOP-lowering medications at baseline and at 24 months were extracted. Weighted estimates of the outcome variables were calculated using random-effects meta-analysis models. Heterogeneity in the outcome measures among the studies was quantified using I\u00b2. Results: Seven studies (three studies for MINIject and four for iStent) comprising 280 eyes were included. At 24 months, there was a greater reduction in IOP from baseline in the MINIject vs. two iStent cohorts (\u22129.57 vs. \u22124.92 mmHg, p = 0.03). The change from baseline in mean medication use was \u22121.00 with MINIject and \u22120.56 medications with iStent (p = 0.26). The mean percentage IOP reduction at 24 months ranged from 36.3\u221242.2% with MINIject compared to 5.2\u221240.7% with iStent, with greater variability in mean change from baseline in IOP observed in the iStent group (I2 = 96.5% vs. 0%). The most frequent adverse events for MINIject were anterior chamber inflammation, best-corrected visual acuity (BCVA) loss, hyphema, and conjunctival hemorrhage, and for iStent, these were device obstruction, BCVA loss, IOP spike, and cataract progression. Conclusions: While both MINIject and iStent inject devices resulted in significant reductions in IOP and IOP medication use, standalone MINIject may provide a greater and more consistent reduction in IOP.<\/jats:p>","DOI":"10.3390\/jcm13247703","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T08:17:00Z","timestamp":1734423420000},"page":"7703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Meta-Analysis of MINIject vs. Two iStents as Standalone Treatment for Glaucoma with 24 Months of Follow-Up"],"prefix":"10.3390","volume":"13","author":[{"given":"Jeremy C. K.","family":"Tan","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, University of New South Wales, Kensington, NSW 2032, Australia"},{"name":"Department of Ophthalmology, Prince of Wales Hospital, Randwick, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-1938","authenticated-orcid":false,"given":"Ashish","family":"Agar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of New South Wales, Kensington, NSW 2032, Australia"},{"name":"Department of Ophthalmology, Prince of Wales Hospital, Randwick, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-9856","authenticated-orcid":false,"given":"Harsha L.","family":"Rao","sequence":"additional","affiliation":[{"name":"Narayana Nethralaya, 63, Bannerghatta Road, Hulimavu, Bangalore 560076, India"},{"name":"University Eye Clinic Maastricht, University Medical Center, 6229 HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6529-3731","authenticated-orcid":false,"given":"Katherin","family":"Awad","sequence":"additional","affiliation":[{"name":"iSTAR Medical, 1300 Wavre, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaweh","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Swiss Visio Glaucoma Research Center, Montchoisi Clinic, 1006 Lausanne, Switzerland"},{"name":"Glaucoma Department, University of Colorado Denver, Denver, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: A review","volume":"311","author":"Weinreb","year":"2014","journal-title":"Jama"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.ophtha.2015.06.039","article-title":"Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up","volume":"122","author":"Blachley","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_3","first-page":"138","article-title":"The case for standalone micro-invasive glaucoma surgery: Rethinking the role of surgery in the glaucoma treatment paradigm","volume":"34","author":"Radcliffe","year":"2023","journal-title":"Curr. 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