{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:39:14Z","timestamp":1791585554663,"version":"4.3.4"},"reference-count":46,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Post-hemicraniectomy patients often need extended intensive care treatment. While computed tomography (CT) is considered the gold standard for regular imaging, its frequent use could be linked to adverse clinical outcomes. This study aimed to assess bedside transcranial ultrasound (TUS) to capture intracranial anatomical structures and pathologies. Methods: We analyzed 19 patients treated in our neurosurgical ICU from 1 January 2023 to 1 February 2024. Six physicians from our unit (three residents and three attending physicians) conducted a retrospective evaluation. A total of 158 sessions, including multiple freeze frames and video footage, were analyzed, including 7 imaging categories, using a Likert scale. Subsequently, correlation between CT and TUS was evaluated for midline (ML) shift, subdural space, lateral ventricular width (LVW), and extent of intracerebral hematoma using the Pearson\u2019s correlation coefficient (r). Results: TUS was performed on average on 8.32\/19.53 days (mean inpatient stay). It provided the lowest Likert scores for the imaging categories ventricular system, midline, subdural space, intraventricular catheter placement, and cortical gyration. Residents reported slightly inferior assessability, resulting in higher scores on the Likert scale (0.02\u20130.93 mean difference compared with attending physicians). A high correlation was shown in terms of ML shift, LVW, and intracerebral hematomas. No relevant correlation was shown in subdural space. Conclusions: TUS is a safe, cost-, and time-efficient method, potentially gaining relevance for imaging post-hemicraniectomy patients. In our setting, the method seemed effective in depicting intraventricular catheter placement, hydrocephalus, ML shift, and space-occupying lesions. Further improvement in image quality could potentially reduce the overall number of indicated CT scans.<\/jats:p>","DOI":"10.3390\/jcm13247704","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T08:17:00Z","timestamp":1734423420000},"page":"7704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Transcranial Ultrasound Imaging in Intensive Care Treatment of Decompressive Hemicraniectomy Patients: A Retrospective Single-Center Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Martin","family":"Petkov","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Bezirkskrankenhaus G\u00fcnzburg, University of Ulm, Lindenallee 2, 89312 G\u00fcnzburg, Germany"},{"name":"Department of Neurosurgery, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-7588","authenticated-orcid":false,"given":"Michal","family":"Hlavac","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bezirkskrankenhaus G\u00fcnzburg, University of Ulm, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bezirkskrankenhaus G\u00fcnzburg, University of Ulm, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Rainer","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bezirkskrankenhaus G\u00fcnzburg, University of Ulm, Lindenallee 2, 89312 G\u00fcnzburg, Germany"},{"name":"Department of Neurosurgery, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bezirkskrankenhaus G\u00fcnzburg, University of Ulm, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-701X","authenticated-orcid":false,"given":"Andrej","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bezirkskrankenhaus G\u00fcnzburg, University of Ulm, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/0885066615601607","article-title":"Decompressive Hemicraniectomy in Acute Neurological Diseases","volume":"31","author":"Crudele","year":"2016","journal-title":"J. Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40560-017-0269-1","article-title":"Early versus late tracheostomy after decompressive craniectomy for stroke","volume":"6","author":"Catalino","year":"2018","journal-title":"J. Intensive Care"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lehmann, F., Schenk, L.M., Ilic, I., Putensen, C., Hadjiathanasiou, A., Borger, V., Zimmermann, J., G\u00fcresir, E., Vatter, H., and Bode, C. (2021). Prolonged Mechanical Ventilation in Patients with Deep-Seated Intracerebral Hemorrhage: Risk Factors and Clinical Implications. J. Clin. Med., 10.","DOI":"10.3390\/jcm10051015"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1055\/s-0037-1608770","article-title":"Imaging in Neurocritical Care Practice","volume":"38","author":"Williamson","year":"2017","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13613-021-00857-x","article-title":"Transcranial sonographic assessment of the third ventricle in neuro-ICU patients to detect hydrocephalus: A diagnostic reliability pilot study","volume":"11","author":"Widehem","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12028-016-0359-2","article-title":"Cerebral Ventricular Dimensions After Decompressive Craniectomy: A Comparison Between Bedside Sonographic Duplex Technique and Cranial Computed Tomography","volume":"26","author":"Bendella","year":"2017","journal-title":"Neurocrit. Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/jon.12756","article-title":"Transcranial Sonography versus CT for Postoperative Monitoring After Decompressive Craniectomy","volume":"30","author":"Mantovani","year":"2020","journal-title":"J. Neuroimaging"},{"key":"ref_8","first-page":"64","article-title":"Comparison between Transcranial Sonography and Computerized Tomography Scans to Assess the Midline Shift in Patients with Traumatic Brain Injury","volume":"27","author":"Kapoor","year":"2023","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/0028-3886.173649","article-title":"Bedside computed tomography in traumatic brain injury: Experience of 10,000 consecutive cases in neurosurgery at a level 1 trauma center in India","volume":"64","author":"Agrawal","year":"2016","journal-title":"Neurol. India"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12028-016-0274-6","article-title":"Intracranial Pressure Changes During Intrahospital Transports of Neurocritically Ill Patients","volume":"25","author":"Kleffmann","year":"2016","journal-title":"Neurocrit. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3171\/jns.1982.57.6.0769","article-title":"Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries","volume":"57","author":"Aaslid","year":"1982","journal-title":"J. Neurosurg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-2007-1012101","article-title":"Transcranial Doppler sonography in neurosurgery","volume":"5","author":"Harders","year":"1984","journal-title":"Ultraschall Med."},{"key":"ref_13","unstructured":"Harders, A. (2012). Neurosurgical Applications of Transcranial Doppler Sonography, Springer Science & Business Media."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1148\/radiology.148.2.6867352","article-title":"Intraoperative neurosurgical ultrasound in the localization and characterization of intracranial masses","volume":"148","author":"Rubin","year":"1983","journal-title":"Radiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10143-015-0627-1","article-title":"Sensitivity and specificity of linear array intraoperative ultrasound in glioblastoma surgery: A comparative study with high field intraoperative MRI and conventional sector array ultrasound","volume":"38","author":"Coburger","year":"2015","journal-title":"Neurosurg. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neurad.2010.12.008","article-title":"Interobserver variability in assessment of cranial ultrasound in very preterm infants","volume":"38","author":"Hagmann","year":"2011","journal-title":"J. Neuroradiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1055\/s-2008-1059656","article-title":"Diagnosing hydrocephalus in infants by ultrasound sector scanning through the open fontanelles. A study comparing ultrasound-sonography and CAT-scan","volume":"12","author":"Strassburg","year":"1981","journal-title":"Neuropediatrics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12028-019-00709-4","article-title":"Bedside Cranial Ultrasonography in Patients with Hemicraniectomies: A Novel Window into Pathology","volume":"31","author":"Srinivasan","year":"2019","journal-title":"Neurocrit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/archneurpsyc.1942.02290060069004","article-title":"An Encephalographic Ratio for Estimating Ventricular Enlargement and Cerebral Atrophy","volume":"47","author":"Evans","year":"1942","journal-title":"Arch. Neurol. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1007\/s10143-022-01778-4","article-title":"Intraoperative ultrasound in brain tumor surgery: A review and implementation guide","volume":"45","author":"Dixon","year":"2022","journal-title":"Neurosurg. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s12028-022-01544-w","article-title":"Bedside Ultrasound for Ventricular Size Monitoring in Patients with PEEK Cranioplasty: A Preliminary Experience of Technical Feasibility in Neurotrauma Setting","volume":"37","author":"Signorelli","year":"2022","journal-title":"Neurocrit. Care"},{"key":"ref_22","first-page":"2","article-title":"Review Ultrasound Hydrogel: A Review on Materials and Method","volume":"1","author":"Afzal","year":"2022","journal-title":"J. Mod. Polym. Chem. Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/RUQ.0000000000000256","article-title":"Reliability of Central Adiposity Assessments Using B-Mode Ultrasound: A Comparison of Linear and Curved Array Transducers","volume":"32","author":"Stoner","year":"2016","journal-title":"Ultrasound Q."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5005\/jp-journals-10071-24662","article-title":"Correlation between Transcranial Ultrasound and CT Head to Detect Clinically Significant Conditions in Post-craniectomy Patients Performed by Emergency Physician: A Pilot Study","volume":"28","author":"Chouhan","year":"2024","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1148\/radiology.167.2.3282264","article-title":"Tendon echogenicity: Ex vivo study","volume":"167","author":"Crass","year":"1988","journal-title":"Radiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5811\/cpcem.2018.7.39379","article-title":"Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient","volume":"2","author":"Sarwal","year":"2018","journal-title":"Clin. Pract. Cases Emerg. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Oliveira, R.A., de Oliveira Lima, M., Paiva, W.S., de S\u00e1 Malbouisson, L.M., Teixeira, M.J., and Bor-Seng-Shu, E. (2017). Comparison between Brain Computed Tomography Scan and Transcranial Sonography to Evaluate Third Ventricle Width, Peri-Mesencephalic Cistern, and Sylvian Fissure in Traumatic Brain-Injured Patients. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00044"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jon199552105","article-title":"Evaluation of the ventricular system in adults by transcranial duplex sonography","volume":"5","author":"Seidel","year":"1995","journal-title":"J. Neuroimaging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/jon.12970","article-title":"Accuracy of bedside bidimensional transcranial ultrasound versus tomodensitometric measurement of the third ventricle","volume":"32","author":"Lasselin","year":"2022","journal-title":"J. Neuroimaging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1097\/CCM.0b013e318246b6ea","article-title":"Usefulness of transcranial echography in patients with decompressive craniectomy: A comparison with computed tomography scan","volume":"40","author":"Caricato","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jocn.2020.09.003","article-title":"Accuracy of freehand external ventricular drain placement in patients after a large decompressive hemicraniectomy","volume":"81","author":"Mizrahi","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gopalakrishnan, M.S., Shanbhag, N.C., Shukla, D.P., Konar, S.K., Bhat, D.I., and Devi, B.I. (2018). Complications of Decompressive Craniectomy. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.00977"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/a-2066-9372","article-title":"Artificial intelligence for the classification of focal liver lesions in ultrasound\u2014A systematic review","volume":"44","author":"Vetter","year":"2023","journal-title":"Ultraschall Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1445-2197.2007.04025.x","article-title":"Analysis of 82 cases of retroperitoneal schwannoma","volume":"77","author":"Li","year":"2007","journal-title":"ANZ J. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/1742271X16688720","article-title":"The ultrasound unit and infection control\u2014Are we on the right track?","volume":"25","author":"Westerway","year":"2017","journal-title":"Ultrasound"},{"key":"ref_36","first-page":"551","article-title":"Outbreak of catheter-related Burkholderia cepacia sepsis acquired from contaminated ultrasonography gel: The importance of strengthening hospital infection control measures in low resourced settings","volume":"28","author":"Viderman","year":"2020","journal-title":"Infez. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/ijmm.IJMM_19_249","article-title":"Ultrasound gel as a source of hospital outbreaks: Indian experience and literature review","volume":"37","author":"Solaimalai","year":"2019","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jhin.2017.09.010","article-title":"Outbreak of Burkholderia cepacia bacteraemia in a tertiary care centre due to contaminated ultrasound probe gel","volume":"98","author":"Abdelfattah","year":"2018","journal-title":"J. Hosp. Infect."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1586\/17434440.2015.1084872","article-title":"Sterile working in ultrasonography: The use of dedicated ultrasound covers and sterile ultrasound gel","volume":"12","author":"Marhofer","year":"2015","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0074-7742(10)90003-2","article-title":"Transcranial sonography--anatomy","volume":"90","author":"Huber","year":"2010","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ultrasmedbio.2004.12.006","article-title":"Multiplanar transcranial ultrasound imaging: Standards, landmarks and correlation with magnetic resonance imaging","volume":"31","author":"Kern","year":"2005","journal-title":"Ultrasound Med. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1023\/A:1009925811965","article-title":"Inter observer variability of the transcranial Doppler ultrasound technique: Impact of lack of practice on the accuracy of measurement","volume":"15","author":"Shen","year":"1999","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1544316720976210","article-title":"Transcranial Doppler: The Fifth Decade","volume":"45","author":"Alexander","year":"2020","journal-title":"J. Vasc. Ultrasound"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00701-024-06310-9","article-title":"Intraoperative visualization of cerebral aneurysms using navigated 3D-ultrasound power-Doppler angiography","volume":"166","author":"Buvala","year":"2024","journal-title":"Acta Neurochir."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jocn.2016.01.029","article-title":"Cerebral hemodynamics and the role of transcranial Doppler applications in the assessment and management of cerebral arteriovenous malformations","volume":"30","author":"Busch","year":"2016","journal-title":"J. Clin. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"De Simone, M., Fontanella, M.M., Choucha, A., Schaller, K., Machi, P., Lanzino, G., Bijlenga, P., Kurz, F.T., L\u00f6vblad, K.-O., and De Maria, L. (2024). Current and Future Applications of Arterial Spin Labeling MRI in Cerebral Arteriovenous Malformations. Biomedicines, 12.","DOI":"10.3390\/biomedicines12040753"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7704\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:53:55Z","timestamp":1760115235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":46,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13247704"],"URL":"https:\/\/doi.org\/10.3390\/jcm13247704","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}