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Programme","award":["TKP2021-EGA-28"],"award-info":[{"award-number":["TKP2021-EGA-28"]}]},{"DOI":"10.13039\/501100012550","name":"Ministry of Innovation and Technology of Hungary","doi-asserted-by":"publisher","award":["739593"],"award-info":[{"award-number":["739593"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Ministry of Innovation and Technology of Hungary","doi-asserted-by":"publisher","award":["FK134863"],"award-info":[{"award-number":["FK134863"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Ministry of Innovation and Technology of Hungary","doi-asserted-by":"publisher","award":["K143549"],"award-info":[{"award-number":["K143549"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Ministry of Innovation and Technology of Hungary","doi-asserted-by":"publisher","award":["BO\/00598\/19\/5"],"award-info":[{"award-number":["BO\/00598\/19\/5"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Ministry of Innovation and Technology of Hungary","doi-asserted-by":"publisher","award":["UNKP-23-3-SZTE-268"],"award-info":[{"award-number":["UNKP-23-3-SZTE-268"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Ministry of Innovation and Technology of Hungary","doi-asserted-by":"publisher","award":["TKP2021-EGA-28"],"award-info":[{"award-number":["TKP2021-EGA-28"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Data on the real-world effectiveness and safety of selective JAK inhibitors (JAKis) in ulcerative colitis (UC) and Crohn\u2019s disease (CD) are limited. Methods: We conducted a multicentre, retrospective study to assess clinical, biochemical, and endoscopic outcomes of selective JAKis in bio-experienced UC and CD. Results: A total of 246 patients (mean age: 40.5 \u00b1 14.5 years; 131 UC and 115 CD) were included with a median follow-up of 7.5 months. Among the CD patients receiving upadacitinib (n = 115), 76.2% achieved clinical remission (CR) at week 12. Furthermore, 59.5% of the upadacitinib-treated UC patients (n = 100) experienced CR at week 8. Corticosteroid-free CR (CSFCR) was achieved by 76.9% of the CD patients and 80.6% of the UC patients at week 24, while 50.0% and 36.1% experienced endoscopic remission. At week 52, 66.7% of the CD and 86.2% of the UC patients achieved CSFCR, whereas 54.5% and 52.9% had endoscopic remission. In UC, the effectiveness of upadacitinib was not compromised by prior tofacitinib failure, while the upadacitinib-treated CD patients with stricturing and penetrating disease were less likely to achieve CR by the end of the induction phase (p = 0.04). C-reactive protein (p[CD] &lt; 0.0001; p[UC] &lt; 0.0001) and faecal calprotectin (p[CD] &lt; 0.0001; p[UC] = 0.02) decreased significantly in both patient groups as early as week 2. Among the filgotinib-treated UC patients (n = 31), 28.6% were in CR at week 12. At week 24 and 52, 59.1% and 60% achieved CSFCR, while 0.0% and 20.0% had endoscopic remission. Both C-reactive protein (p = 0.04) and faecal calprotectin (p = 0.04) decreased significantly by week 12. Hyperlipidaemia (9.7\u20139.8%) was the most common adverse event. Conclusions: Selective JAKis are rapidly effective and safe for treating refractory, moderate-to-severe CD and UC.<\/jats:p>","DOI":"10.3390\/jcm13247804","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:42:18Z","timestamp":1734680538000},"page":"7804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Real-World Effectiveness and Safety of Selective JAK Inhibitors in Ulcerative Colitis and Crohn\u2019s Disease: A Retrospective, Multicentre Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8816-0138","authenticated-orcid":false,"given":"Bernadett","family":"Farkas","sequence":"first","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Bessissow","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy K.","family":"Limdi","sequence":"additional","affiliation":[{"name":"Northern Care Alliance NHS Foundation Trust, Manchester M6 8HD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma","family":"Sethi-Arora","sequence":"additional","affiliation":[{"name":"Northern Care Alliance NHS Foundation Trust, Manchester M6 8HD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-6205","authenticated-orcid":false,"given":"Anna","family":"Kagramanova","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Center Named after A. S. Loginov, Moscow 111123, Russia"},{"name":"Research Institute of Health Organization and Medical Management, Moscow 115088, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Knyazev","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Center Named after A. S. Loginov, Moscow 111123, Russia"},{"name":"State Scientific Centre of Coloproctology Named after A.N. Ryzhyh, Moscow 123423, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bezzio","sequence":"additional","affiliation":[{"name":"IBD Center, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1572-0118","authenticated-orcid":false,"given":"Alessandro","family":"Armuzzi","sequence":"additional","affiliation":[{"name":"IBD Center, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Lukas","sequence":"additional","affiliation":[{"name":"Clinical and Research Centre for Inflammatory Bowel Diseases, 19000 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Michalopoulos","sequence":"additional","affiliation":[{"name":"General Hospital of Athens \u201cG. Gennimatas\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chaskova","sequence":"additional","affiliation":[{"name":"Department of Coloproctology, Irkutsk Regional Hospital, Irkutsk 664528, Russia"},{"name":"Federal Scientific Center of Surgery and Traumatology, Irkutsk 664003, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo Vincenzo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Azienda Ospedale Universit\u00e0 of Padua, 35128 Padua, Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padua, 35124 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Gastroenterology Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1454-2412","authenticated-orcid":false,"given":"Antonio","family":"Rispo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hungarian Defence Forces Military Hospital, 1062 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-2534","authenticated-orcid":false,"given":"Simone","family":"Saibeni","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-151X","authenticated-orcid":false,"given":"Rafal","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology with IBD Unit, Clinical Hospital 2, 35301 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-7030","authenticated-orcid":false,"given":"Mohamed","family":"Attauabi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital\u2014Herlev and Gentofte, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios S.","family":"Fousekis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University Hospital of Ioannina, 45500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0068","authenticated-orcid":false,"given":"P\u00e9ter","family":"Bacsur","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"},{"name":"HCEMM-USZ Translational Colorectal Research Group, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Res\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hungarian Defence Forces Military Hospital, 1062 Budapest, Hungary"},{"name":"HCEMM-USZ Translational Colorectal Research Group, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"B\u00e1lint","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Iv\u00e1ny","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Szepes","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"B\u0151sze","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"F\u00e1bi\u00e1n","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e1ta","family":"Bor","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Farkas","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"},{"name":"HCEMM-USZ Translational Colorectal Research Group, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6488","authenticated-orcid":false,"given":"Peter L.","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"},{"name":"Department of Internal Medicine and Oncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJMra1907607","article-title":"Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease","volume":"385","author":"Baumgart","year":"2021","journal-title":"N. 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