{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:17Z","timestamp":1791309857343,"version":"4.3.1"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body\u2019s basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p &lt; 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.<\/jats:p>","DOI":"10.3390\/jcm14010061","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T21:13:18Z","timestamp":1735247598000},"page":"61","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Iron Metabolism and Inflammation in Children with Cerebral Palsy"],"prefix":"10.3390","volume":"14","author":[{"given":"Ozhan","family":"Orhan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Mardin Artuklu University, Mardin 47100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul Sahika","family":"Gokdemir","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Mardin Artuklu University, Mardin 47100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/biomechanics3010008","article-title":"Quantification of Cycling Smoothness in Children with Cerebral Palsy","volume":"3","author":"Behboodi","year":"2023","journal-title":"Biomechanics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/iub.1635","article-title":"Iron Metabolism and the Inflammatory Response","volume":"69","author":"Martins","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"668544","DOI":"10.3389\/fped.2021.668544","article-title":"Multi-Organ Dysfunction in Cerebral Palsy","volume":"9","author":"Allen","year":"2021","journal-title":"Front Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"618435","DOI":"10.3389\/fnins.2021.618435","article-title":"Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases","volume":"15","author":"Ravanfar","year":"2021","journal-title":"Front Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.3390\/nu7115469","article-title":"Dietary Intakes and Nutritional Issues in Neurologically Impaired Children","volume":"7","author":"Penagini","year":"2015","journal-title":"Nutrients"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103508","DOI":"10.1016\/j.ridd.2019.103508","article-title":"Inflammatory biomarkers in children with cerebral palsy: A systematic review","volume":"95","author":"Moreira","year":"2019","journal-title":"Res. 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