{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:10:07Z","timestamp":1785557407026,"version":"3.56.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: To review the outcomes of patients who underwent repeated vertebroplasty (VP) surgery for adjacent segment fractures (ASF), defined as new osteoporotic vertebral fractures occurring at levels immediately above or below a previously treated vertebra. Methods: From 1 January 2018, to 31 December 2020, forty-one patients who developed ASF following initial VP and underwent repeated VP were enrolled in our study. Radiographic measurements included single and two-segment kyphotic angles (SKA and TKA), and anterior and mid-vertebral body height (AVH and MVH). Patient-reported outcomes included back pain assessed with the visual analog scale (VAS) and the Oswestry Disability Index (ODI). Results: The procedure significantly reduced the mean single kyphotic angle (SKA) by 4.8\u00b0 \u00b1 6.8\u00b0 (p &lt; 0.01) and the two-segment kyphotic angle (TKA) by 3.0\u00b0 \u00b1 7.9\u00b0 (p = 0.02), along with increases in anterior and mid-body height by 0.3 \u00b1 0.5 cm and 0.3 \u00b1 0.6 cm (both p &lt; 0.01). However, there was a slight restoration loss in SKA and TKA at a 20.1-month follow-up. Patient-reported outcomes revealed substantial pain reduction, with the VAS score dropping from 8 to 1 (p &lt; 0.0001) and the mean ODI score improving from 59.7 to 28.9 (p &lt; 0.0001). The complication rate was 34.1%, including nonunion, de novo fractures, cement leakage, and neurological deficits. Additionally, 7.3% of cases necessitated further surgical interventions. Conclusions: Repeated VP for ASF improves vertebral alignment parameters and patient-reported outcomes, but with a high rate of complications and reoperation.<\/jats:p>","DOI":"10.3390\/jcm14010166","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:34:19Z","timestamp":1735630459000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficiency and Safety of Repeated Vertebroplasty for Adjacent Segment Fractures"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-9276","authenticated-orcid":false,"given":"Bo-Sheng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Medical Education, National Cheng Kung University Hospital, No.138, Sheng Li Road, North Dist., Tainan 11558, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsin","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-8332","authenticated-orcid":false,"given":"Shih-Tien","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"},{"name":"Ministry of Health and Welfare, Kinmen Hospital, Kinmen County 89142, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"},{"name":"Department of Orthopedics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-8357","authenticated-orcid":false,"given":"Chien-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, China Medical University Hsinchu Hospital, Hsinchu County 30058, Taiwan"},{"name":"Department of Orthopedics, College of Medicine, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-0604","authenticated-orcid":false,"given":"Kuan-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"},{"name":"Department of Orthopedics, China Medical University Hsinchu Hospital, Hsinchu County 30058, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00198-017-3909-3","article-title":"Worldwide prevalence and incidence of osteoporotic vertebral fractures","volume":"28","author":"Ballane","year":"2017","journal-title":"Osteoporos. 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