{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:16:27Z","timestamp":1792606587114,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: The aim of this retrospective study was to compare corneal parameters and compliance using a Pentacam HR\u2013Scheimpflug (Pentacam HR) and a swept-source OCT Casia (Casia) in keratoconus (KC) patients post penetrating keratoplasty (PKP) and KC patients without PKP, as well as a control group. Pachymetry measurements were also analyzed using a spectral domain OCT Solix (OCT Solix), Pentacam HR, and Casia. Methods: The study included 71 patients (136 keratoconic eyes; group A), 86 eyes with KC post-PKP (group B), 50 eyes with KC without PKP (group C), and 52 control participants (104 eyes). All participants were adults, Polish Caucasian, and met specific inclusion criteria. Patients with ophthalmological or systemic diseases, cognitive impairment, or pregnancy were excluded. Corneal parameters were measured using two devices (Casia and Pentacam HR), while pachymetry was assessed with three devices (Casia, Pentacam HR, and OCT Solix), with the inter-device agreement and group differences analyzed. Results: Significant differences (p &lt; 0.05) were found across all groups. The post-PKP KC eyes showed significant differences in all front parameters and K2 and Astig. back, while the non-PKP KC eyes showed differences in the K1 back (p = 0.025). The controls displayed differences in all parameters except front astigmatism (p = 0.61). The Pentacam HR overestimated the thinnest corneal thickness (TCT) compared to the OCT Casia across groups. The inter-device agreement was excellent for the anterior parameters (ICC &gt; 0.9) but good for the posterior parameters and TCT. Conclusions: This study highlights significant variability in corneal and pachymetry measurements across devices, with OCT Casia providing more consistent and clinically reliable results than Pentacam HR. Clinicians should exercise caution when using these devices interchangeably, particularly for posterior parameters and TCT.<\/jats:p>","DOI":"10.3390\/jcm14010238","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:02:02Z","timestamp":1735880522000},"page":"238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of a Scheimpflug Camera and Optical Coherence Tomography in Evaluating Keratoconic Eyes Post Keratoplasty"],"prefix":"10.3390","volume":"14","author":[{"given":"Anna Maria","family":"Gadamer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Academy of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Miklaszewski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Academy of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-5272","authenticated-orcid":false,"given":"Dominika","family":"Janiszewska-Bil","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland"},{"name":"Collegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-8020","authenticated-orcid":false,"given":"Anita","family":"Lyssek-Boro\u0144","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Academy of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-1691","authenticated-orcid":false,"given":"Dariusz","family":"Dobrowolski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland"},{"name":"Department of Ophthalmology, District Railway Hospital, 40-760 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Medical University of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-5790","authenticated-orcid":false,"given":"Edward","family":"Wyl\u0119ga\u0142a","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, District Railway Hospital, 40-760 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Medical University of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-7145","authenticated-orcid":false,"given":"Beniamin Oskar","family":"Grabarek","sequence":"additional","affiliation":[{"name":"Collegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-5391","authenticated-orcid":false,"given":"Katarzyna","family":"Krysik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Academy of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Rabinowitz","year":"1998","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and Related Noninflammatory Corneal Thinning Disorders","volume":"28","author":"Krachmer","year":"1984","journal-title":"Surv. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5005\/jp-journals-10025-1002","article-title":"The Epidemiology and Etiology of Keratoconus","volume":"1","author":"Millodot","year":"2012","journal-title":"Int. J. Keratoconus Ectatic Corneal Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/aos.12811","article-title":"Lamellar Changes in the Keratoconic Cornea","volume":"93","author":"Mathew","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jfo.2013.05.004","article-title":"K\u00e9ratoc\u00f4ne","volume":"36","author":"Touboul","year":"2013","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Karamichos, D., and Hjortdal, J. (2014). Keratoconus: Tissue Engineering and Biomaterials. J. Funct. Biomater., 5.","DOI":"10.3390\/jfb5030111"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1097\/ICO.0000000000000504","article-title":"Contemporary Treatment Paradigms in Keratoconus","volume":"34","author":"McGhee","year":"2015","journal-title":"Cornea"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ajo.2022.11.019","article-title":"Penetrating Keratoplasty Versus Deep Anterior Lamellar Keratoplasty for Advanced Stage of Keratoconus","volume":"248","author":"Feizi","year":"2023","journal-title":"Am. J. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10792-016-0255-y","article-title":"A Case of Unilateral Circumscribed Posterior Keratoconus Evaluated by Three Different Imaging Tools: Optical Coherence Tomography, Videokeratography, and Scheimpflug Corneal Tomography","volume":"37","author":"Spadea","year":"2016","journal-title":"Int. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/ICO.0000000000002781","article-title":"Keratoconus: Diagnosis and Staging","volume":"41","author":"Belin","year":"2022","journal-title":"Cornea"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jcrs.2012.02.036","article-title":"Comparison of Anterior Chamber Depth Measurements by 3-Dimensional Optical Coherence Tomography, Partial Coherence Interferometry Biometry, Scheimpflug Rotating Camera Imaging, and Ultrasound Biomicroscopy","volume":"38","author":"Nakakura","year":"2012","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.aopr.2022.10.005","article-title":"Advances in swept-source optical coherence tomography and optical coherence tomography angiography","volume":"3","author":"Zheng","year":"2022","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1219","DOI":"10.1097\/MD.0000000000001219","article-title":"Longitudinal Evaluation of Cornea with Swept-Source Optical Coherence Tomography and Scheimpflug Imaging Before and After Lasik","volume":"94","author":"Chan","year":"2015","journal-title":"Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Li, K., Li, X., Wang, Q., Wang, L., and Huang, Y. (2022). Kinetic Pupillary Size Using Pentacam in Myopia. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.981436"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Brunner, M., Czanner, G., Vinciguerra, R., Romano, V., Ahmad, S., Batterbury, M., Britten, C., Willoughby, C.E., and Kaye, S.B. (2018). Improving Precision for Detecting Change in the Shape of the Cornea in Patients with Keratoconus. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-30173-7"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40662-016-0036-8","article-title":"Corneal Topography in Keratoconus: State of the Art","volume":"3","year":"2016","journal-title":"Eye Vis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Antonio, L., Viggiano, P., Ferro, G., Toto, L., D\u2019Aloisio, R., Porreca, A., Nicola, M., and Mastropasqua, R. (2020). Retinal Vascular Metrics Difference by Comparison of Two Image Acquisition Modes Using a Novel OCT Angiography Prototype. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243074"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Savastano, M.C., Rizzo, C., Gambini, G., Savastano, A., Falsini, B., Bacherini, D., Caputo, C.G., Kilian, R., Faraldi, F., and De Vico, U. (2021). Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections. Diagnostics, 11.","DOI":"10.3390\/diagnostics11111958"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1364\/OE.20.004710","article-title":"Split-Spectrum Amplitude-Decorrelation Angiography with Optical Coherence Tomography","volume":"20","author":"Jia","year":"2012","journal-title":"Opt. Express"},{"key":"ref_20","first-page":"386","article-title":"Agreement Between Swept-Source Optical Coherence Tomography and Rotating Scheimpflug Camera in Measurement of Corneal Parameters in Normal and Keratoconic Eyes","volume":"18","author":"Ghassemi","year":"2023","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10792-016-0347-8","article-title":"Comparison of Scheimpflug and Swept-Source Anterior Segment Optical Coherence Tomography in Normal and Keratoconus Eyes","volume":"37","author":"Ghoreishi","year":"2017","journal-title":"Int. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jcrs.2014.08.040","article-title":"Comparison of Dual Rotating Scheimpflug-Placido, Swept-Source Optical Coherence Tomography, and Placido-Scanning-Slit Systems","volume":"41","author":"Lee","year":"2015","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jcrs.2011.10.027","article-title":"Reliability and Repeatability of Swept-Source Fourier-Domain Optical Coherence Tomography and Scheimpflug Imaging in Keratoconus","volume":"38","author":"Szalai","year":"2012","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1111\/aos.12622","article-title":"Comparative Analysis of Corneal Measurements Obtained from a Scheimpflug Camera and an Integrated Placido-Optical Coherence Tomography Device in Normal and Keratoconic Eyes","volume":"93","author":"Viswanathan","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_25","unstructured":"(2024, July 03). Comparability and Repeatability of Pachymetry in Keratoconus Using Four Noncontact Techniques\u2014PMC, Available online: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4705708\/."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.jcrs.2009.12.033","article-title":"Assessment of Central Corneal Thickness in Normal, Keratoconus, and Post-Laser in Situ Keratomileusis Eyes Using Scheimpflug Imaging, Spectral Domain Optical Coherence Tomography, and Ultrasound Pachymetry","volume":"36","author":"Grewal","year":"2010","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1097\/01.ico.0000157422.01146.e9","article-title":"Agreement and Repeatability of Central Thickness Measurement in Normal Corneas Using Ultrasound Pachymetry and the OCULUS Pentacam","volume":"24","year":"2005","journal-title":"Cornea"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.ophtha.2007.02.017","article-title":"Agreement Among 3 Methods to Measure Corneal Thickness: Ultrasound Pachymetry, Orbscan II, and Visante Anterior Segment Optical Coherence Tomography","volume":"114","author":"Li","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3109\/02713683.2012.745878","article-title":"Corneal Thickness and Volume Measurements by Swept Source Anterior Segment Optical Coherence Tomography in Normal Subjects","volume":"38","author":"Fukuda","year":"2013","journal-title":"Curr. Eye Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Feldman, R.M., Kim, G., Chuang, A.Z., Shiraishi, A., Okamoto, K., and Tsukamoto, M. (2023). Comparison Between the CASIA SS-1000 and Pentacam in Measuring Corneal Curvatures and Corneal Thickness Maps. BMC Ophthalmol., 23.","DOI":"10.1186\/s12886-023-02768-w"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3928\/1081597X-20220114-02","article-title":"Repeatability and Comparison of Corneal Tomography in Mild to Severe Keratoconus Between the Anterior Segment OCT MS-39 and Pentacam","volume":"38","author":"Seiler","year":"2022","journal-title":"J. Refract. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, Y., Gokul, A., McGhee, C., and Ziaei, M. (2021). Repeatability and Agreement of Biometric Measurements Using Spectral Domain Anterior Segment Optical Coherence Tomography and Scheimpflug Tomography in Keratoconus. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0248659"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ophtha.2006.01.063","article-title":"Comparison of Central Corneal Thickness Measurements by Rotating Scheimpflug Camera, Ultrasonic Pachymetry, and Scanning-Slit Corneal Topography","volume":"113","author":"Amano","year":"2006","journal-title":"Ophthalmology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/ICO.0000000000001133","article-title":"Noncontact Evaluation of Corneal Grafts: Swept-Source Fourier Domain OCT Versus High-Resolution Scheimpflug Imaging","volume":"36","author":"Szalai","year":"2017","journal-title":"Cornea"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e486","DOI":"10.1111\/aos.13298","article-title":"Comparison of Corneal Measurements in Keratoconus Using Swept-Source Optical Coherence Tomography and Combined Placido-Scheimpflug Imaging","volume":"95","author":"Chan","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ortiz-Toquero, S., Fluente, C., Auladell, C., and Arnalich-Montiel, F. (2023). Influence of Keratoconus Severity on Detecting True Progression with Scheimpflug Imaging and Anterior Segment Optical Coherence Tomography. Life, 13.","DOI":"10.3390\/life13071474"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/1\/238\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:22:19Z","timestamp":1759918939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/1\/238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14010238"],"URL":"https:\/\/doi.org\/10.3390\/jcm14010238","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]}}}