{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:36:30Z","timestamp":1759970190940,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian Scientific Research Fund","award":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"],"award-info":[{"award-number":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"]}]},{"name":"Studium Irodah\u00e1z 1093 Budapest, Czuczor u. 10. 1 emelet, Hungary","award":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"],"award-info":[{"award-number":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"]}]},{"name":"Nemzeti Fejleszt\u00e9si \u00dcgyn\u00f6ks\u00e9g 1077 Budapest, Wessel\u00e9nyi u. 20-22, Hungary","award":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"],"award-info":[{"award-number":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"]}]},{"name":"European Union","award":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"],"award-info":[{"award-number":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"]}]},{"name":"National Office for Research and Technology of Hungary","award":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"],"award-info":[{"award-number":["OTKA 84196","T\u00c1MOP 4.2.1.\/B-09\/1\/KONV-2010-0007","T\u00c1MOP-4.2.2\/B-10\/1-2010-0024","TECH-09-A1-2009-0113 (mAB-CHIC)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Patients with hyperlipidemia are of interest because of the possible interplay between chronic local dental infections and hyperlipidemia. This interventional clinical study aimed to evaluate the oral health status of hyperlipidemic patients receiving lipid-lowering therapy for at least 6 months and the effects of non-surgical and surgical dental treatments on serum C-reactive protein (CRP) levels and lipid markers. Methods: Twenty-eight patients with controlled hyperlipidemia and 18 healthy controls were enrolled in the study. All participants underwent dental examinations (clinical evaluation, X-ray imaging, and microbial analysis of subgingival and supragingival plaque samples) at baseline. Hyperlipidemic patients received periodontal, endodontic, and dentoalveolar surgical treatments. Serum CRP and lipid parameters were assessed at baseline, 1 week, and 3 months, while subgingival and supragingival plaque samples were analyzed at baseline and 3 months after completing dental treatments. Results: At the 3-month follow-up, clinical periodontal characteristics, including the plaque index, gingival index, and periodontal probing depth, improved significantly (p &lt; 0.05). A significant shift in microflora was observed in both subgingival and supragingival plaque samples (p &lt; 0.05), alongside improvements in periodontal values and a significant reduction in serum CRP levels (p &lt; 0.05). Serum cholesterol levels decreased significantly, while moderate improvements in serum triglycerides, low-density lipoprotein, and high-density lipoprotein levels were observed but were not statistically significant (p &gt; 0.05). Conclusions: Treating local dental inflammation is associated with a significant decrease in CRP and cholesterol levels and may serve as beneficial adjunct therapy alongside lipid-lowering therapy in patients with hyperlipidemia.<\/jats:p>","DOI":"10.3390\/jcm14010241","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:02:02Z","timestamp":1735880522000},"page":"241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Combined Periodontal, Endodontic, and Dentoalveolar Surgical Treatments on Laboratory Parameters in Patients with Hyperlipidemia\u2014A Clinical Interventional Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Ren\u00e1ta","family":"Martos","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9761-9595","authenticated-orcid":false,"given":"Mariann","family":"Harangi","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Institute of Health Studies, Faculty of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9805-7483","authenticated-orcid":false,"given":"Judit","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Petz Alad\u00e1r County Teaching Hospital, Microbiol. Lab. 9024. Gy\u0151r. Vasv\u00e1ri P\u00e1l u. 2-4, 9024 Hungary, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anett","family":"F\u00f6ldv\u00e1ri","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-5666","authenticated-orcid":false,"given":"J\u00e1nos","family":"S\u00e1ndor","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"},{"name":"HUN-REN-DE Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-794X","authenticated-orcid":false,"given":"\u00c9va","family":"Katona","sequence":"additional","affiliation":[{"name":"Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3458-154X","authenticated-orcid":false,"given":"Ildik\u00f3","family":"Tar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Paragh","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-5965","authenticated-orcid":false,"given":"Csongor","family":"Kiss","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-8768","authenticated-orcid":false,"given":"Ildik\u00f3","family":"M\u00e1rton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"},{"name":"Faculty of Health Sciences, University of Debrecen, Kassai \u00fat 26, 4028 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1902\/jop.2005.76.11-S.2089","article-title":"Systemic Effects of Periodontitis: Epidemiology of Periodontal Disease and Cardiovascular Disease","volume":"76","author":"Beck","year":"2005","journal-title":"J. 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