{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:08:19Z","timestamp":1787987299790,"version":"build-2784847793"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Industry Development Institute (KHIDI)","award":["RS-2023-KH136575"],"award-info":[{"award-number":["RS-2023-KH136575"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["RS-2023-KH136575"],"award-info":[{"award-number":["RS-2023-KH136575"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Recurrent aphthous stomatitis is a common oral mucosal disorder characterized by painful ulcerations and frequent recurrences, which can significantly impair quality of life. This study explores the efficacy of zinc-enriched multivitamin supplementation (ZnVita, containing 22.5 mg of elemental zinc) for the treatment of recurrent aphthous stomatitis in treatment-na\u00efve patients, aiming to diminish the reliance on immunomodulatory drugs. Methods: Conducted as a retrospective observational study at a tertiary referral hospital from 2013 to 2023, we analyzed 201 patients who received ZnVita daily for a minimum duration of one month as their initial management. Patients who were using systemic immunomodulating agents or met the diagnostic criteria for Beh\u00e7et\u2019s disease were excluded. Results: Of the 201 patients, 95 presented with an oral ulcer alone and 106 exhibited additional symptoms associated with Beh\u00e7et\u2019s disease. Efficacy analysis was conducted on 155 patients due to follow-up loss or incomplete data. Among them, 58.7% (91\/155) showed partial or significant responses. Patients with BD-related symptoms were significantly more prevalent among non-responders (64.1%, 41\/64) compared to responders (42.9%, 39\/91), with a statistically significant difference (p = 0.009). Treatment was well-tolerated, with mild gastrointestinal adverse events reported in only 2.5% of cases. Conclusions: These results suggest that zinc-enriched multivitamin supplementation offers a beneficial and safe initial treatment alternative for a considerable proportion of treatment-na\u00efve recurrent aphthous stomatitis patients, especially those without concurrent symptoms of Beh\u00e7et\u2019s disease, showcasing its potential in reducing the future need for immunomodulatory treatments.<\/jats:p>","DOI":"10.3390\/jcm14010260","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:43:04Z","timestamp":1736145784000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Na\u00efve Recurrent Aphthous Stomatitis Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-6855","authenticated-orcid":false,"given":"Hye Rin","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-3553","authenticated-orcid":false,"given":"Kyung Bae","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-9854","authenticated-orcid":false,"given":"Do-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.clindermatol.2016.02.020","article-title":"Recurrent aphthous stomatitis","volume":"34","author":"Cui","year":"2016","journal-title":"Clin. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1079-2104(96)80403-3","article-title":"Recurrent aphthous stomatitis: An update","volume":"81","author":"Ship","year":"1996","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-0528.2007.00329.x","article-title":"Risk indicators for recurrent aphthous ulcers among adults in the US","volume":"35","author":"Chattopadhyay","year":"2007","journal-title":"Community Dent. Oral. Epidemiol."},{"key":"ref_4","unstructured":"Plewa, M.C., and Chatterjee, K. (2023). Recurrent Aphthous Stomatitis. StatPearls, StatPearls Publishing LLC."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ajhp\/58.1.41","article-title":"Treatment strategies for recurrent oral aphthous ulcers","volume":"58","author":"Barrons","year":"2001","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_6","first-page":"e168","article-title":"Treatment of recurrent aphthous stomatitis. A literature review","volume":"6","year":"2014","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MD.0b013e318211bf28","article-title":"Behcet disease: Evolution of clinical manifestations","volume":"90","author":"Ideguchi","year":"2011","journal-title":"Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cden.2013.12.002","article-title":"Recurrent aphthous stomatitis","volume":"58","author":"Akintoye","year":"2014","journal-title":"Dent. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1111\/j.1365-2230.2009.03384.x","article-title":"Comparison of the clinical features of recurrent aphthous stomatitis and Behcet\u2019s disease","volume":"34","author":"Oh","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1590\/S1807-59322009000300008","article-title":"Systemic treatment in severe cases of recurrent aphthous stomatitis: An open trial","volume":"64","author":"Mimura","year":"2009","journal-title":"Clinics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5021\/ad.2022.34.1.22","article-title":"Safety, Efficacy, and Drug Survival of Colchicine in Recurrent Aphthous Stomatitis in a Real-World Setting","volume":"34","author":"Oh","year":"2022","journal-title":"Ann. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-0714.1991.tb00950.x","article-title":"Recurrent aphthous ulceration: Vitamin B1, B2 and B6 status and response to replacement therapy","volume":"20","author":"Nolan","year":"1991","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3122\/jabfm.2009.01.080113","article-title":"Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: A randomized, double-blind, placebo-controlled trial","volume":"22","author":"Volkov","year":"2009","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.14219\/jada.archive.2012.0179","article-title":"Multivitamin therapy for recurrent aphthous stomatitis: A randomized, double-masked, placebo-controlled trial","volume":"143","author":"Lalla","year":"2012","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lin, P.-H., Sermersheim, M., Li, H., Lee, P.H.U., Steinberg, S.M., and Ma, J. (2017). Zinc in wound healing modulation. Nutrients, 10.","DOI":"10.3390\/nu10010016"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e33170","DOI":"10.1097\/MD.0000000000033170","article-title":"Comparison of oral zinc supplement and placebo effect in improving the T-cells regeneration in patients undergoing autologous hematopoietic stem cell transplantation: Clinical trial study","volume":"103","author":"Nikoonezhad","year":"2024","journal-title":"Medicine"},{"key":"ref_17","first-page":"e8197","article-title":"Role of Zinc in Mucosal Health and Disease: A Review of Physiological, Biochemical, and Molecular Processes","volume":"12","author":"Hassan","year":"2020","journal-title":"Cureus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0377-1237(02)80083-1","article-title":"Serum Zinc Levels in Cutaneous Disorders","volume":"58","author":"Arora","year":"2002","journal-title":"Med. J. Armed Forces India"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Halboub, E., Al-Maweri, S.A., Parveen, S., Al-Wesabi, M., Al-Sharani, H.M., Al-Sharani, A., Al-Kamel, A., Albashari, A., and Shamala, A. (2021). Zinc supplementation for prevention and management of recurrent aphthous stomatitis: A systematic review. J. Trace Elem. Med. Biol., 68.","DOI":"10.1016\/j.jtemb.2021.126811"},{"key":"ref_20","first-page":"66","article-title":"Revised diagnostic criteria for Behcet\u2019s disease in 1987","volume":"28","author":"Mizushima","year":"1988","journal-title":"Ryumachi"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1346-8138.2006.00128.x","article-title":"Oral zinc sulfate in the treatment of Behcet\u2019s disease: A double blind cross-over study","volume":"33","author":"Sharquie","year":"2006","journal-title":"J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2012.06.007","article-title":"Zinc deficiency induces production of the proinflammatory cytokines IL-1\u03b2 and TNF\u03b1 in promyeloid cells via epigenetic and redox-dependent mechanisms","volume":"24","author":"Wessels","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.15537\/smj.2022.43.5.20210916","article-title":"Impact on the survival of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio on prognosis in children with Hodgkin lymphoma","volume":"43","author":"Ertan","year":"2022","journal-title":"Saudi Med. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3758068","DOI":"10.1155\/2018\/3758068","article-title":"Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Injured Patients: Which Ratio to Choose to Predict Outcome and Nature of Bacteremia?","volume":"2018","author":"Djordjevic","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ajcn\/51.2.225","article-title":"Zinc toxicity","volume":"51","author":"Fosmire","year":"1990","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/jclinpath-2014-202837","article-title":"The risk of copper deficiency in patients prescribed zinc supplements","volume":"68","author":"Duncan","year":"2015","journal-title":"J. Clin. Pathol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/1\/260\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:23:03Z","timestamp":1759918983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/1\/260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,5]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14010260"],"URL":"https:\/\/doi.org\/10.3390\/jcm14010260","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,5]]}}}