{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:05:01Z","timestamp":1793657101264,"version":"4.5.1"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: To evaluate the effects of subthreshold micropulse laser treatment (SMLT) on choroidal architecture in chronic central serous chorioretinopathy (CSC) and their correlations with functional outcomes. Methods: This retrospective study included 48 eyes with chronic CSC that were treated with 577 nm SMLT. The choroidal thickness (CT); Sattler\u2019s layer and choriocapillaris complex thickness (SLCCT); Haller\u2019s layer thickness (HLT); subretinal fluid (SRF); and best-corrected visual acuity (BCVA) were assessed at baseline and at 2 months post treatment. Results: At 2 months, the SLCCT increased from 185.92 \u00b1 80.89 \u03bcm to 214.17 \u00b1 83.36 \u03bcm (p = 0.023), and the total CT increased from 444.46 \u00b1 80.43 \u03bcm to 484.33 \u00b1 93.19 \u03bcm (p = 0.002). The SRF height decreased from 140.38 \u00b1 95.89 \u03bcm to 57.58 \u00b1 63.54 \u03bcm (p &lt; 0.001), with complete resolution in 79.2% of cases. The BCVA improved from 0.41 \u00b1 0.48 to 0.22 \u00b1 0.30 logMAR (p &lt; 0.001). Changes in the SLCCT correlated negatively with BCVA changes (r = \u22120.48, p = 0.025) and positively with total CT changes (r = 0.687, p &lt; 0.001). Conclusions: SMLT induces significant choroidal remodeling in chronic CSC, particularly affecting the Sattler\u2013Bruch layer complex. The increase in the SLCCT correlates with visual improvement, challenging the conventional understanding of choroidal thinning in CSC treatment.<\/jats:p>","DOI":"10.3390\/jcm14020306","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:38:41Z","timestamp":1736221121000},"page":"306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Choroidal Remodeling After Subthreshold Micropulse Laser in Chronic Central Serous Chorioretinopathy: Short-Term Outcomes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-967X","authenticated-orcid":false,"given":"Pasquale","family":"Viggiano","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-1262","authenticated-orcid":false,"given":"Giacomo","family":"Scotti","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba Chiara","family":"Termite","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Savastano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ente Ecclesiastico Ospedale Generale Regionale \u201cF. Miulli\u201d, 70021 Acquaviva delle Fonti, Italy"},{"name":"Ophthalmology Unit, Libera Universit\u00e0 Mediterranea Degennaro, 70010 Casamassima, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-899X","authenticated-orcid":false,"given":"Giacomo","family":"Boscia","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcangelo","family":"Clemente","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Salvelli","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermete","family":"Giancipoli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2787-3517","authenticated-orcid":false,"given":"Francesco","family":"Pignatelli","sequence":"additional","affiliation":[{"name":"Eye Clinic, \u201cSS. Annunziata\u201d Hospital, ASL Taranto, 74121 Taranto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ente Ecclesiastico Ospedale Generale Regionale \u201cF. Miulli\u201d, 70021 Acquaviva delle Fonti, Italy"},{"name":"Ophthalmology Unit, Libera Universit\u00e0 Mediterranea Degennaro, 70010 Casamassima, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Alessio","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Boscia","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0420.2007.00889.x","article-title":"Central Serous Chorioretinopathy","volume":"86","author":"Wang","year":"2008","journal-title":"Acta Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0161-6420(01)00951-4","article-title":"Clinical Characteristics of Central Serous Chorioretinopathy in Women","volume":"109","author":"Perkins","year":"2002","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101236","DOI":"10.1016\/j.preteyeres.2024.101236","article-title":"Central Serous Chorioretinopathy: An Evidence-Based Treatment Guideline","volume":"101","author":"Feenstra","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.05.003","article-title":"Central Serous Chorioretinopathy: Recent Findings and New Physiopathology Hypothesis","volume":"48","author":"Daruich","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40662-023-00349-y","article-title":"Central Serous Chorioretinopathy: Updates in the Pathogenesis, Diagnosis and Therapeutic Strategies","volume":"10","author":"Zhang","year":"2023","journal-title":"Eye Vis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.survophthal.2012.07.004","article-title":"Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment","volume":"58","author":"Nicholson","year":"2013","journal-title":"Surv. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000439600","article-title":"Subthreshold Micropulse Laser (577 Nm) Treatment in Chronic Central Serous Chorioretinopathy","volume":"234","author":"Scholz","year":"2015","journal-title":"Ophthalmologica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.ophtha.2008.08.026","article-title":"Subthreshold Diode Micropulse Photocoagulation for the Treatment of Chronic Central Serous Chorioretinopathy with Juxtafoveal Leakage","volume":"115","author":"Chen","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Viggiano, P., Grassi, M.O., Boscia, G., Pignataro, M., Petruzzella, G., Borrelli, E., Molfetta, T., Alessio, G., and Boscia, F. (2022). Short-Term Morphofunctional Changes in Previously Treated Neovascular AMD Eyes Switched to Brolucizumab. J. Clin. Med., 11.","DOI":"10.21203\/rs.3.rs-1685029\/v1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1097\/IAE.0000000000003530","article-title":"Baseline Sattler layer-choriocapillaris complex thickness cutoffs associated with age-related macular degeneration progression","volume":"42","author":"Amato","year":"2022","journal-title":"Retina"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/bjo-2023-323577","article-title":"Comparative Assessment of Subretinal Hyper-Reflective Material in Patients Treated with Brolucizumab versus Aflibercept in HAWK and HARRIER","volume":"108","author":"Sadda","year":"2024","journal-title":"Br. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2147\/OPTH.S112431","article-title":"Microsecond Yellow Laser for Subfoveal Leaks in Central Serous Chorioretinopathy","volume":"10","author":"Ambiya","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.ophtha.2018.04.021","article-title":"Half-Dose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial","volume":"125","author":"Fauser","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/IAE.0000000000000285","article-title":"Low-Intensity\/High-Density Subthreshold MicroPulse Diode Laser for Chronic Central Serous Chorioretinopathy","volume":"35","author":"Malik","year":"2015","journal-title":"Retina"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Torrellas, B., Filloy, A., Wu, L., Chhablani, J., and Romero-Aroca, P. (2023). Effectiveness, Safety and Choroidal Changes of a Fovea-Sparing Technique for the Treatment of Chronic Central Serous Chorioretinopathy with Yellow Subthreshold Laser. J. Clin. Med., 12.","DOI":"10.3390\/jcm12031127"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Prasuhn, M., Miura, Y., Tura, A., Rommel, F., Kakkassery, V., Sonntag, S., Grisanti, S., and Ranjbar, M. (2021). Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study. J. Clin. Med., 10.","DOI":"10.20944\/preprints202105.0163.v1"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.preteyeres.2009.12.002","article-title":"The Multifunctional Choroid","volume":"29","author":"Nickla","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cheung, C.M.G., Dansingani, K.K., Koizumi, H., Lai, T.Y.Y., Sivaprasad, S., Boon, C.J.F., Van Dijk, E.H.C., Chhablani, J., Lee, W.K., and Freund, K.B. (2024). Pachychoroid Disease: Review and Update. Eye.","DOI":"10.1038\/s41433-024-03253-4"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1007\/s40123-023-00816-8","article-title":"Choriocapillaris Reperfusion in Resolved Chronic Central Serous Chorioretinopathy Treated with Eplerenone: Long-Term Effects on the Fellow Eye","volume":"12","author":"Viggiano","year":"2023","journal-title":"Ophthalmol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/IAE.0b013e3182953df4","article-title":"Pachychoroid Pigment Epitheliopathy","volume":"33","author":"Warrow","year":"2013","journal-title":"Retina"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/IAE.0000000000003004","article-title":"Intervortex venous anastomosis in pachychoroid-related disorders","volume":"41","author":"Spaide","year":"2021","journal-title":"Retina"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/IAE.0000000000001655","article-title":"Outer nuclear layer thinning in pachychoroid pigment epitheliopathy","volume":"38","author":"Ersoz","year":"2018","journal-title":"Retina"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1097\/IAE.0000000000002051","article-title":"Inner choroidal flow signal attenuation in pachychoroid disease: Optical coherence tomography angiography","volume":"38","author":"Dansingani","year":"2018","journal-title":"Retina"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/IAE.0000000000000742","article-title":"En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography","volume":"36","author":"Dansingani","year":"2016","journal-title":"Retina"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41433-022-02091-6","article-title":"Choroidal Modifications Assessed by Means of Choroidal Vascularity Index after Oral Eplerenone Treatment in Chronic Central Serous Chorioretinopathy","volume":"37","author":"Toto","year":"2022","journal-title":"Eye"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ophtha.2012.07.048","article-title":"Subfoveal Choroidal Thickness: The Beijing Eye Study","volume":"120","author":"Wei","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1136\/bjo-2022-321617","article-title":"In Vivo Assessment of Associations between Photoreceptors Structure and Macular Perfusion in Type 1 Diabetes","volume":"107","author":"Viggiano","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.survophthal.2024.09.011","article-title":"Choroidal Thickness after Anti-Vascular Endothelial Growth Factor in Typical Neovascular Age-Related Macular Degeneration\u2014A Systematic Review and Meta-Analysis","volume":"70","author":"Hoven","year":"2025","journal-title":"Surv. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/IAE.0000000000002988","article-title":"Choriocapillaris vascular parameters in normal eyes and those with pachychoroid with and without disease","volume":"41","author":"Spaide","year":"2021","journal-title":"Retina"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1097\/IAE.0000000000001005","article-title":"Low-intensity\/high-density subthreshold diode micropulse laser for central serous chorioretinopathy","volume":"36","author":"Luttrull","year":"2016","journal-title":"Retina"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41433-019-0692-8","article-title":"Efficacy and Safety of Subthreshold Micropulse Laser Compared with Threshold Conventional Laser in Central Serous Chorioretinopathy","volume":"34","author":"Sun","year":"2020","journal-title":"Eye"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajo.2024.04.025","article-title":"Pathogenesis of Central Serous Chorioretinopathy and the Link between Choroidal Hyperpermeability and RPE Pump Reversal","volume":"266","author":"Fossataro","year":"2024","journal-title":"Am. J. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/306\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:24:08Z","timestamp":1759919048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14020306"],"URL":"https:\/\/doi.org\/10.3390\/jcm14020306","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}