{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:27:04Z","timestamp":1782631624433,"version":"3.54.5"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Asthmatic children who tested positive for COVID-19 experienced changes in lung function and persistent symptoms following SARS-CoV-2 infection, even for several months after diagnosis, and with the same features as in an acute phase. This study aimed to analyze a pediatric age group (between 0 and 17 years old) diagnosed with asthma, and SARS-CoV-2 infection attending regular monitoring visits in a Pediatric Department of a Regional Tertiary Hospital (Filantropia Clinical Municipal Hospital Craiova, Romania) during the COVID-19 pandemic and post-pandemic time interval (i.e., March 2020\u2013July 2024), and identify how the infection influenced their long-term symptoms and treatment. Materials and Methods. The following variables were recorded: demographic data (gender, age group, residence), data related to allergies (allergic rhinitis, atopic dermatitis, and food allergies), the presence of exacerbations, the fraction of exhaled nitric oxide, the ventilatory function, the asthma phenotype (allergic or non-allergic), as well as the GINA assessment of asthma control at clinical visits were analyzed. SARS-CoV-2 infections were evaluated in terms of year of infection, symptoms, cough presence and persistence, and modifications of the asthma treatment during and after COVID-19 disease. The data were statistically analyzed with SPSS, using the Mann\u2013Whitney U, Kruskal\u2013Wallis H, and Chi-Square tests. Results. A lower incidence of COVID-19 cases was recorded in the first pandemic of asthmatic patients (2020 and 2021), but an increase in the rate of cases was observed at the beginning of the second pandemic, in 2022. The nitric oxide values in asthmatic children who were infected with SARS-CoV-2 were statistically significantly increased (p &lt; 0.0005), especially for children with persistent cough for more than 4 weeks. A significant increase in the number of exacerbations was also observed in patients who tested positive for SARS-CoV-2 infection (p &lt; 0.0005). Ventilatory function values were statistically significantly different in asthmatic children with and without SARS-CoV-2 infection (p &lt; 0.05). Conclusions. The persistence of cough after the acute phase of SARS-CoV-2 infection as well as the changes in ventilatory tests emphasize the need of periodic medical check-ups, as well as the implementation of a therapeutic regimen appropriate for each pediatric patient.<\/jats:p>","DOI":"10.3390\/jcm14020356","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:17:08Z","timestamp":1736399828000},"page":"356","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retrospective Study of the Impact of SARS-CoV-2 Infection on Asthma Control in Children"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6707-7882","authenticated-orcid":false,"given":"Jaqueline","family":"Abdul-Razzak","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3210-1212","authenticated-orcid":false,"given":"Alexandru Dan","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Carmen","family":"Niculescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-5919","authenticated-orcid":false,"given":"Mihai","family":"Gafencu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d of Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana Octavia","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Elena","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Anghelina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9234-6097","authenticated-orcid":false,"given":"Cristian","family":"Gheonea","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u201cMother and Child\u201d, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"ref_1","unstructured":"GBD 2019 Diseases and Injuries Collaborators (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204\u20131222."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bush, A. (2024). Evaluating Severe Therapy-Resistant Asthma in Children: Diagnostic and Therapeutic Strategies. Medicina, 60.","DOI":"10.3390\/medicina60111799"},{"key":"ref_3","unstructured":"(2024, November 01). Global Strategy for Asthma Management and Prevention GINA. Available online: https:\/\/ginasthma.org\/2023-gina-main-report\/."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ioniuc, I.K., Lupu, A., Dragan, F., Tarnita, I., Alexoae, M.M., Streanga, V., Mitrofan, C., Thet, A.A., Nedelcu, A.H., and Salaru, D.L. (2024). Oxidative Stress and Antioxidants in Pediatric Asthma\u2019s Evolution and Management. Antioxidants, 13.","DOI":"10.3390\/antiox13111331"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mrfmmm.2009.09.005","article-title":"Chronic inflammation and asthma","volume":"690","author":"Murdoch","year":"2010","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1081-1206(10)60826-5","article-title":"Asthma: A syndrome composed of heterogeneous diseases","volume":"101","author":"Borish","year":"2008","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40348-023-00159-1","article-title":"Childhood asthma phenotypes and endotypes: A glance into the mosaic","volume":"10","author":"Foppiano","year":"2023","journal-title":"Mol. Cell Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Miculini\u0107, A., Mrki\u0107 Kobal, I., Ku\u0161an, T., Turkalj, M., and Plavec, D. (2024). Current Challenges in Pediatric Asthma. Children, 11.","DOI":"10.3390\/children11060632"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ajem.2020.11.037","article-title":"Characterizing Pediatric Emergency Department Visits during the COVID-19 Pandemic","volume":"41","author":"Pines","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.15585\/mmwr.mm6918e2","article-title":"Public Health Response to the Initiation and Spread of Pandemic COVID-19 in the United States, February 24\u2013April 21, 2020","volume":"69","author":"Schuchat","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e2020035238","DOI":"10.1542\/peds.2020-035238","article-title":"Pediatric COVID-19 Cases Prelockdown and Postlockdown in Italy","volume":"147","author":"Bellino","year":"2021","journal-title":"Pediatrics"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Vogel, M., Beger, C., Gausche, R., Jurkutat, A., Pfaeffle, R., Korner, A., Meigen, C., Poulain, T., and Kiess, W. (2021). COVID-19 pandemic and families\u2019 utilization of well-child clinics and pediatric practices attendance in Germany. BMC Res. Notes, 14.","DOI":"10.1186\/s13104-021-05562-3"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jmv.26398","article-title":"A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19)","volume":"93","author":"Cui","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Machado, M.B., Fajardo, T.C.G., de Oliveira, L.B., de Quadros Junior, A.C., Catalan, D.T., Piovesan, K.C., Garcia, M.E.D., da Silva, M.F., Dezena, R.C.A.B., and Passos, S.D. (2022). Mild and Asymptomatic Coronavirus Disease in Children, Adolescents, and Household Contacts and Prolonged Viral Excretion. Int. J. Microbiol., 2022.","DOI":"10.1155\/2022\/5625104"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/pai.13356","article-title":"Upper airway involvement in pediatric COVID-19","volume":"31","author":"Parisi","year":"2020","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Indolfi, C., Klain, A., Dinardo, G., D\u2019Addio, E., Ferrara, S., Decimo, F., Ciprandi, G., Tosca, M.A., and Miraglia del Giudice, M. (2024). COVID-19 Pediatric Follow-Up: Respiratory Long COVID-Associated Comorbidities and Lung Ultrasound Alterations in a Cohort of Italian Children. Children, 11.","DOI":"10.3390\/children11020166"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00431-021-04345-z","article-title":"Long COVID symptoms and duration in SARS-CoV-2 positive children\u2014A nationwide cohort study","volume":"181","author":"Borch","year":"2022","journal-title":"Eur. J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13052-022-01233-6","article-title":"Italian intersociety consensus on management of long covid in children","volume":"48","author":"Esposito","year":"2022","journal-title":"Ital. J. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.3346\/jkms.2022.37.e35","article-title":"Risk Factors for Severe COVID-19 in Children: A Systematic Review and Meta-Analysis","volume":"37","author":"Choi","year":"2022","journal-title":"J. Korean Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Costa, V.C.d., Montarroyos, U.R., Lopes, K.A.d.M., and Santos, A.C.O.d. (2024). Severity Profile of COVID-19 in Hospitalized Pediatric Patients. Children, 11.","DOI":"10.3390\/children11101249"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"E551","DOI":"10.1503\/cmaj.200617","article-title":"Asthma and COVID-19","volume":"192","author":"Abrams","year":"2020","journal-title":"CMAJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.jaip.2020.03.012","article-title":"COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic","volume":"8","author":"Shaker","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_23","unstructured":"(2024, November 01). Robert Koch Institut. Available online: https:\/\/www.rki.de\/EN\/Content\/infections\/epidemiology\/inf_dis_Germany\/COVID-19\/Long-COVID\/content-total.html."},{"key":"ref_24","unstructured":"National Institute of Health (2024, November 01). Long COVID Resources and Research About Long COVID, Available online: https:\/\/www.nhlbi.nih.gov\/covid\/long-covid#:~:text=Long%20COVID%2C%20long%2Dhaul%20COVID,than%20symptoms%20of%20COVID%2D19%20."},{"key":"ref_25","unstructured":"(2024, November 01). World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., Rumyantsev, M., Gamirova, A., Bairashevskaia, A., and Petrova, P. (2022). Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12\u2009months after hospital discharge: A prospective, cohort study in Moscow (StopCOVID). BMC Med., 20.","DOI":"10.2139\/ssrn.4020142"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"n1648","DOI":"10.1136\/bmj.n1648","article-title":"Long COVID-mechanisms, risk factors, and management","volume":"374","author":"Crook","year":"2021","journal-title":"BMJ"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41591-020-0843-2","article-title":"Respiratory virus shedding in exhaled breath and efficacy of face masks","volume":"6","author":"Leung","year":"2020","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1398-9995.2010.02505.x","article-title":"Viruses and bacteria in acute asthma exacerbations--a GA\u00b2 LEN-DARE systematic review","volume":"66","author":"Papadopoulos","year":"2011","journal-title":"Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1016\/j.jaip.2020.05.045","article-title":"Initial effects of the COVID-19 pandemic on pediatric asthma emergency department utilization","volume":"8","author":"Kenyon","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/archdischild-2020-319522","article-title":"COVID-19 lockdown dropped the rate of paediatric asthma admissions","volume":"105","author":"Krivec","year":"2020","journal-title":"Arch. Dis. Child."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/all.14787","article-title":"Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort","volume":"76","author":"Papadopoulos","year":"2021","journal-title":"Allergy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12016-020-08797-3","article-title":"COVID-19 and asthma: Reflection during the pandemic","volume":"59","author":"Liu","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liuzzo Scorpo, M., Ferrante, G., and La Grutta, S. (2021). An Overview of Asthma and COVID-19: Protective Factors Against SARS-COV-2 in Pediatric Patients. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.661206"},{"key":"ref_35","first-page":"S1","article-title":"AAO-HNSF. Clinical practice guideline: Allergic rhinitis","volume":"152","author":"Seidman","year":"2015","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41572-020-00227-0","article-title":"Allergic rhinitis","volume":"6","author":"Bousquet","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1067\/mai.2001.115569","article-title":"Allergic rhinitis: Definition, epidemiology, pathophysiology, detection, and diagnosis","volume":"108","author":"Skoner","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jaci.2009.05.013","article-title":"Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey","volume":"124","author":"Meltzer","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.pcl.2019.06.004","article-title":"Allergic Rhinitis in Children and Adolescents","volume":"66","author":"Montejo","year":"2019","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0091-6749(90)90223-Q","article-title":"Longitudinal changes in atopy during a 4-year period: Relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren","volume":"85","author":"Peat","year":"1990","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cheng, M., Dai, Q., Liu, Z., Wang, Y., and Zhou, C. (2024). New progress in pediatric allergic rhinitis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1452410"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12519-023-00765-z","article-title":"Risk factors for long COVID in children and adolescents: A systematic review and meta-analysis","volume":"20","author":"Rayner","year":"2024","journal-title":"World J. Pediatr."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mazzone, S.B. (2023). Neurobiology of Coughing in Children. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237285"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-022-00370-w","article-title":"Cough hypersensitivity and chronic cough","volume":"8","author":"Chung","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liu, L., Zhang, L., Zhou, P., Zhou, W., Li, L., Zeng, L., Li, N., Zhao, R., and Han, T. (2024). Cough symptoms in children following COVID-19: A single-center retrospective study. Front. Pediatr., 12.","DOI":"10.3389\/fped.2024.1301571"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ppul.26779","article-title":"Lung functionassessment in children with Long-Covid syndrome","volume":"59","author":"Sansone","year":"2024","journal-title":"Pediatr. Pulmonol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.1097\/INF.0000000000002937","article-title":"Sequelae of COVID-19 in Hospitalized Children: A 4-Months Follow-Up","volume":"39","author":"Denina","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/jama.2021.11880","article-title":"Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents","volume":"326","author":"Radtke","year":"2021","journal-title":"JAMA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9621572","DOI":"10.1155\/2021\/9621572","article-title":"Asthma and COVID-19: Emphasis on Adequate Asthma Control","volume":"2021","author":"Nassoro","year":"2021","journal-title":"Can. Respir. J."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Agondi, R.C., Menechino, N., Marinho, A.K.B.B., Kalil, J., and Giavina-Bianchi, P. (2024). Worsening of asthma control after COVID-19. Front. Med., 9.","DOI":"10.3389\/fmed.2022.882665"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinial Applications. An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FeNO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/17476348.2018.1475233","article-title":"Biomarkers for severe allergic asthma in children: Could they be useful to guide disease control and use of omalizumab?","volume":"12","author":"Amat","year":"2018","journal-title":"Expert. Rev. Respir. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mayocp.2017.11.012","article-title":"The diagnostic accuracy of fractional exhaled nitric oxide testing in asthma: A systematic review and meta-analyses","volume":"93","author":"Wang","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Barreto, M., Evangelisti, M., Montesano, M., Martella, S., and Villa, M.P. (2020). Pulmonary Function Testing in Asthmatic Children. Tests to Assess Outpatients During the Covid-19 Pandemic. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.571112"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Cameli, P., Bargagli, E., Bergantini, L., d'Alessandro, M., Giugno, B., Gentili, F., and Sestini, P. (2021). Alveolar Nitric Oxide as a Biomarker of COVID-19 Lung Sequelae: A Pivotal Study. Antioxidants, 10.","DOI":"10.3390\/antiox10091350"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"100463","DOI":"10.1016\/j.eclinm.2020.100463","article-title":"Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery","volume":"25","author":"Zhao","year":"2020","journal-title":"eClinicalMedicine"},{"key":"ref_58","first-page":"CC01","article-title":"Assessment of Pulmonary Function in COVID-19 Recovered Health Science Students: A Descriptive Cross-sectional Study","volume":"18","author":"Patil","year":"2024","journal-title":"J. Clin. Diag. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/02770903.2012.690481","article-title":"The utility of forced expiratory flow between 25% and 75% of vital capacity in predicting childhood asthma morbidity and severity","volume":"49","author":"Rao","year":"2012","journal-title":"J. Asthma"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.anai.2016.04.029","article-title":"Association of FEF25%-75% and bronchodilator reversibility with asthma control and asthma morbidity in inner-city children with asthma","volume":"117","author":"Kanchongkittiphon","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jaci.2010.05.016","article-title":"Forced expiratory flow between 25% and 75% of vital capacity and FEV1\/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values","volume":"126","author":"Simon","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4274\/MMJ.galenos.2024.15853","article-title":"Impact of Long COVID on Lung Function in Children","volume":"39","author":"Onay","year":"2024","journal-title":"Medeni. Med. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2147\/IJGM.S319436","article-title":"The Long-Term Impact of COVID-19 Pneumonia on the Pulmonary Function of Survivors","volume":"14","author":"Salem","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pulmoe.2020.10.013","article-title":"Respiratory function in patients post-infection by COVID-19: A systematic review and meta-analysis","volume":"27","author":"Burgos","year":"2021","journal-title":"Pulmonology"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Chen, X., Han, P., Kong, Y., and Shen, K. (2024). The relationship between changes in peak expiratory flow and asthma exacerbations in asthmatic children. BMC Pediatr., 24.","DOI":"10.1186\/s12887-024-04754-7"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Dondi, A., Calamelli, E., Piccinno, V., Ricci, G., Corsini, I., Biagi, C., and Lanari, M. (2017). Acute Asthma in the Pediatric Emergency Department: Infections Are the Main Triggers of Exacerbations. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/9687061"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1378\/chest.129.3.573","article-title":"No symptoms, no asthma: The acute episodic disease belief is associated with poor self-management among inner-city adults with persistent asthma","volume":"129","author":"Halm","year":"2006","journal-title":"CHEST"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/02770903.2022.2059510","article-title":"Reduced asthma morbidity during COVID-19 in minority children: Is medication adherence a reason?","volume":"60","author":"Feldman","year":"2023","journal-title":"J. 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