{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:38:35Z","timestamp":1764333515868,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Systemic corticosteroids are frequently used to manage acute respiratory diseases in infancy, but concerns about the long-term impacts on growth remain. This study aimed to evaluate the impact of short courses of systemic steroids administered exclusively during infancy on final adult height, weight, and BMI, adjusted by sex and cumulative steroid use. Methods: A prospective cohort study was conducted including 257 participants (49.4% males, 11.2 \u00b1 3.5 years) of which two groups of cases were firstly analyzed: the control group (CG) and the group that received systemic steroids only during infancy (ssccINF). Final adult height, weight, and BMI were compared between the groups, adjusted also for breastfeeding history, food allergies, history of fractures, physical activity, and family smoking habits. Results: No significant differences in final adult height were observed between males in the CG and ssccINF group (179.32 vs. 179.40). In females, the ssccINF group was slightly shorter by 2.5 cm (165.51 vs. 162.98), although this difference was not linked to cumulative days of steroid use during infancy (mean = 3.91 \u00b1 2.37, p = 0.37). A regression analysis revealed no significant influence of additional covariates on height, weight, or BMI outcomes. Conclusions: Short courses of systemic steroids administered exclusively during infancy did not appear to have a significant long-term impact on growth. The minor height difference observed in females was not associated with steroid use duration. These findings suggest that the benefits of short-term steroid therapy, such as reduced hospitalizations and improved management of acute respiratory diseases, outweigh potential risks, supporting its safe use in clinical practice.<\/jats:p>","DOI":"10.3390\/jcm14020387","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:54:27Z","timestamp":1736416467000},"page":"387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short Course of Systemic Steroids for Acute Respiratory Diseases During Infancy and Final Adult Height, Weight, and BMI: Preliminary Results from a Prospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-664X","authenticated-orcid":false,"given":"Athina","family":"Papadopoulou","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Asthma Unit, KAT General Hospital, 14561 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavroula","family":"Lampidi","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Asthma Unit, KAT General Hospital, 14561 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-9028","authenticated-orcid":false,"given":"Konstantinos","family":"Makris","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Department, KAT General Hospital, 14561 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-9292","authenticated-orcid":false,"given":"Efstathios","family":"Chronopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Research of the Musculosceletal System, National and Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1164\/rccm.201107-1174CI","article-title":"Corticosteroids in respiratory diseases in children","volume":"185","author":"Bush","year":"2012","journal-title":"Am. J. Respir Crit. Care. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.21037\/atm.2019.07.77","article-title":"Steroids in pediatric acute respiratory distress syndrome","volume":"7","author":"Cristiani","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.21037\/tp-21-577","article-title":"Safety of corticosteroids in the treatment of acute respiratory disease in children: A systematic review and meta-analysis","volume":"11","author":"Yang","year":"2022","journal-title":"Transl. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e028511","DOI":"10.1136\/bmjopen-2018-028511","article-title":"Safety of corticosteroids in young children with acute respiratory conditions: A systematic review and meta-analysis","volume":"9","author":"Fernandes","year":"2019","journal-title":"BMJ Open"},{"key":"ref_5","first-page":"13","article-title":"Natural history of growth and body composition in juvenile idiopathic arthritis","volume":"72","author":"Bechtold","year":"2009","journal-title":"Horm. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/adc.87.2.93","article-title":"The impact of corticosteroids on growth and bone health","volume":"87","author":"Mushtaq","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00431-014-2479-z","article-title":"Effect of glucocorticoids on growth and bone mineral density in children with nephrotic syndrome","volume":"174","author":"Ribeiro","year":"2015","journal-title":"Eur. J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/archdischild-2015-309522","article-title":"Systematic review of the toxicity of short-course oral corticosteroids in children","volume":"101","author":"Aljebab","year":"2016","journal-title":"Arch. Dis. Child."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"896","DOI":"10.23736\/S2724-5276.22.07074-4","article-title":"The impact of glucocorticoids on bone health and growth: Endocrine and non-endocrine effects in children and young patients","volume":"75","author":"Cipolla","year":"2023","journal-title":"Minerva. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201904-0903SO","article-title":"Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management","volume":"201","author":"Bleecker","year":"2020","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"ref_11","first-page":"89","article-title":"Short-Term Systemic Corticosteroids: Appropriate Use in Primary Care","volume":"101","author":"Dvorin","year":"2020","journal-title":"Am. Fam. Physician."},{"key":"ref_12","first-page":"1117","article-title":"Patient outcomes, health care resource use, and costs associated with high versus low HEDIS asthma medication ratio","volume":"23","author":"Luskin","year":"2017","journal-title":"J. Manag. Care. Spec. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"190151","DOI":"10.1183\/16000617.0151-2019","article-title":"Short-course systemic corticosteroids in asthma: Striking the balance between efficacy and safety","volume":"29","author":"Price","year":"2020","journal-title":"Eur. Respir. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"j1415","DOI":"10.1136\/bmj.j1415","article-title":"Short term use of oral corticosteroids and related harms among adults in the United States: Population based cohort study","volume":"357","author":"Waljee","year":"2017","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1590\/1984-0462;2017\/;35;2;00007","article-title":"Mechanisms and importance in pediatric practice","volume":"35","author":"Sarinho","year":"2017","journal-title":"Rev. Paul. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/jbmr.2511","article-title":"Canadian Steroid-Associated Osteoporosis in Pediatric Population (STOPP) Consortium. Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic Disorders","volume":"30","author":"LeBlanc","year":"2015","journal-title":"J. Bone. Miner. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1081\/JAS-120019038","article-title":"Growth of asthmatic children before long-term treatment with inhaled corticosteroids","volume":"40","author":"Moudiou","year":"2003","journal-title":"J. Asthma."},{"key":"ref_18","first-page":"CD009471.7","article-title":"Inhaled corticosteroids in children with persistent asthma: Effects on growth","volume":"7","author":"Zhang","year":"2014","journal-title":"Cochrane. Database. Syst. Rev."},{"key":"ref_19","first-page":"CD009878","article-title":"Inhaled corticosteroids in children with persistent asthma: Dose-response effects on growth","volume":"7","author":"Pruteanu","year":"2014","journal-title":"Cochrane. Database. Syst. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e000756","DOI":"10.1136\/bmjresp-2020-000756","article-title":"Systemic adverse effects from inhaled corticosteroid use in asthma: A systematic review","volume":"7","author":"Griffiths","year":"2020","journal-title":"BMJ Open Respir. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1056\/NEJMoa1203229","article-title":"Effect of inhaled glucocorticoids in childhood on adult height","volume":"367","author":"Kelly","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Loke, Y.K., Blanco, P., Thavarajah, M., and Wilson, A.M. (2015). Impact of Inhaled Corticosteroids on Growth in Children with Asthma: Systematic Review and Meta-Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133428"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jped.2018.10.005","article-title":"The impact of asthma and its treatment on growth: An evidence-based review","volume":"95","author":"Zhang","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.31128\/AJGP-11-19-5164","article-title":"Multiple short courses of corticosteroids in children","volume":"50","author":"Harding","year":"2021","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1542\/peds.2007-3381","article-title":"The effect of long-term corticosteroid use on bone mineral density in children: A prospective longitudinal assessment in the childhood asthma management program (CAMP) study","volume":"122","author":"Kelly","year":"2008","journal-title":"Pediatrics"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/387\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:25:57Z","timestamp":1759919157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14020387"],"URL":"https:\/\/doi.org\/10.3390\/jcm14020387","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,1,9]]}}}