{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:40:11Z","timestamp":1759920011071,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Vaccination against SARS-CoV-2 has been vital in alleviating the spread of the recent pandemic. We aimed to estimate the frequency and type of adverse events related to SARS-CoV-2 vaccine in patients with lupus nephritis (LN), and assess its impact, if any, on the risk of subsequent reactivation of nephritis. Methods: This was a retrospective, multicenter study which included patients with biopsy-proven LN, who had received at least one vaccine dose. Patients who ended up with end-stage kidney disease (ESKD) prior to vaccination or were diagnosed with LN after vaccination were excluded. Adverse events, systemic or local, COVID-19 outcomes (full recovery, death, or long COVID-19), outcome of LN (remission, refractory disease, relapse, ESKD or death), demographics, laboratory measurements, and immunosuppressive regimens were recorded. Results: Sixty-seven patients were included. The median age was 33 (20\u201346) years. Induction therapy for LN was administered to 92.5% of patients and 74.6% received maintenance therapy. Of these, 94.02% were in remission at vaccination. The BNT162b2 mRNA vaccine was administered in 97.01% of cases, with mild systemic adverse symptoms in 28.35% (myalgias 17.91%, headache 13.43%, arthralgias 13.43%, and fever 10.44%) and local adverse effects in 35.82% (pain 25.37%, swelling 13.43%). Overall, among patients in remission upon vaccination, two (3.17%) experienced a LN relapse within 5.75 (\u00b10.25) months, while 75% of those with active disease at vaccination achieved remission within 21 (\u00b12) months. Conclusions: SARS-CoV-2 vaccination appears safe for LN patients without serious adverse events occurring, and there is no significant impact in the clinical course of the disease.<\/jats:p>","DOI":"10.3390\/jcm14020406","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T03:48:11Z","timestamp":1736480891000},"page":"406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety Profile of SARS-CoV-2 Vaccination in Patients with Lupus Nephritis: A Retrospective Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-0432","authenticated-orcid":false,"given":"Dimitra","family":"Petrou","sequence":"first","affiliation":[{"name":"Division of Nephrology, 2nd Department of Internal Medicine, Attikon University Hospital, School of Health Sciences, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaragdi","family":"Marinaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Laiko Hospital Athens, School of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelagia","family":"Kriki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Alexandroupolis, School of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-5847","authenticated-orcid":false,"given":"Sofia","family":"Flouda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, 4th Department of Internal Medicine, Attikon University Hospital, School of Health Sciences, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliki","family":"Venetsanopoulou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital of Ioannina, School of Health Sciences, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi","family":"Voulgari","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital of Ioannina, School of Health Sciences, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggeliki","family":"Sardeli","sequence":"additional","affiliation":[{"name":"Division of Nephrology, 2nd Department of Internal Medicine, Attikon University Hospital, School of Health Sciences, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Drouzas","sequence":"additional","affiliation":[{"name":"Division of Nephrology, 2nd Department of Internal Medicine, Attikon University Hospital, School of Health Sciences, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Panagoutsos","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Alexandroupolis, School of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Liapis","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harikleia","family":"Gakiopoulou","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-8923","authenticated-orcid":false,"given":"Sophia","family":"Lionaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology, 2nd Department of Internal Medicine, Attikon University Hospital, School of Health Sciences, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-022-05522-2","article-title":"The WHO estimates of excess mortality associated with the COVID-19 pandemic","volume":"613","author":"Msemburi","year":"2023","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102870","DOI":"10.1016\/j.jaut.2022.102870","article-title":"Abnormalities of T cells in systemic lupus erythematosus: New insights in pathogenesis and therapeutic strategies","volume":"132","author":"Li","year":"2022","journal-title":"J. Autoimmun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2215\/CJN.05780616","article-title":"Update on Lupus Nephritis","volume":"12","author":"Almaani","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Lupus Nephritis Work Group (2024). KDIGO 2024 Clinical Practice Guideline for the management of LUPUS NEPHRITIS. Kidney Int., 105, S1\u2013S69.","DOI":"10.1016\/j.kint.2023.09.002"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1086\/587063","article-title":"Vaccination in patients with chronic rheumatic or autoimmune diseases","volume":"46","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrrheum.2014.206","article-title":"Vaccination of patients with autoimmune inflammatory rheumatic diseases","volume":"11","author":"Westra","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/annrheumdis-2019-215882","article-title":"2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases","volume":"79","author":"Furer","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/acr.25045","article-title":"2022 American College of Rheumatology Guideline for Vaccinations in Patients with Rheumatic and Musculoskeletal Diseases","volume":"75","author":"Bass","year":"2023","journal-title":"Arthritis Care Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/annrheumdis-2021-221636","article-title":"Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: Data from the COVID-19 Global Rheumatology Alliance","volume":"81","author":"Izadi","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1002\/art.42372","article-title":"American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 5","volume":"75","author":"Curtis","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/annrheumdis-2020-217871","article-title":"Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: Data from the COVID-19 Global Rheumatology Alliance physician-reported registry","volume":"79","author":"Gianfrancesco","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e29872","DOI":"10.2196\/29872","article-title":"COVID-19 Vaccine Hesitancy and Acceptance Among Individuals with Cancer, Autoimmune Diseases, or Other Serious Comorbid Conditions: Cross-sectional, Internet-Based Survey","volume":"8","author":"Tsai","year":"2022","journal-title":"JMIR Public Health Surveill."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/25785826.2023.2300163","article-title":"Risk of disease flares after SARS-CoV-2 mRNA vaccination in patients with systemic lupus erythematosus","volume":"47","author":"Kikuchi","year":"2024","journal-title":"Immunol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1016\/S2665-9913(21)00221-6","article-title":"Tolerance of COVID-19 vaccination in patients with systemic lupus erythematosus: The international VACOLUP study","volume":"3","author":"Felten","year":"2021","journal-title":"Lancet Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wang, P., Ni, J., Chu, Y.Y., Chen, Q.Q., Wu, G.C., Fang, Y., Chen, C., Zhang, R.D., Jiang, L.Q., and Zhao, Y. (2022). Seroprevalence of SARS-CoV-2-specific antibodies and vaccination-related adverse events in systemic lupus erythematosus and rheumatoid arthritis. Biomed. Pharmacother., 150.","DOI":"10.1016\/j.biopha.2022.112997"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/art.41937","article-title":"Evaluation of Immune Response and Disease Status in Systemic Lupus Erythematosus Patients Following SARS-CoV-2 Vaccination","volume":"74","author":"Izmirly","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/09612033241232576","article-title":"Immunogenicity and safety of BNT162b2 vaccination in adolescents with systemic lupus erythematosus","volume":"33","author":"Piyaphanee","year":"2024","journal-title":"Lupus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/acr2.11299","article-title":"Impaired Antibody Response to the BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine in Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis","volume":"3","author":"Bartels","year":"2021","journal-title":"ACR Open Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1016\/j.vaccine.2022.08.068","article-title":"Hesitancy for SARS-CoV-2 vaccines and post-vaccination flares in patients with systemic lupus erythematosus","volume":"40","author":"Mok","year":"2022","journal-title":"Vaccine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e244177","DOI":"10.1001\/jamanetworkopen.2024.4177","article-title":"Reports of COVID-19 Vaccine Adverse Events in Predominantly Republican vs Democratic States","volume":"7","author":"Asch","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/cid\/ciae132","article-title":"Effectiveness of the 2023\u20132024 Formulation of the COVID-19 Messenger RNA Vaccine","volume":"79","author":"Shrestha","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2273155","DOI":"10.1080\/21645515.2023.2273155","article-title":"Comparing the immune response and protective effect of COVID-19 vaccine under different vaccination strategies","volume":"19","author":"Zhao","year":"2023","journal-title":"Hum. Vaccin. Immunother."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/406\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:26:18Z","timestamp":1759919178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14020406"],"URL":"https:\/\/doi.org\/10.3390\/jcm14020406","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,1,10]]}}}