{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:29:27Z","timestamp":1768256967047,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Despite considerable research on pregnancy outcomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the consequences for infants exposed to the virus in utero remain unclear. Methods: A retrospective cohort study was conducted, encompassing 392 mother\u2013infant pairs delivered between April 2020 and July 2021 at a community hospital network in northeastern Pennsylvania, USA. Of these, 198 mothers had a confirmed SARS-CoV-2 infection during pregnancy, while 194 did not. Infant outcomes were compared between the two groups. Results: Pregnant women with a SARS-CoV-2 infection during their gestation exhibited higher rates of obesity (p = 0.04) with higher body mass indices (BMI) (p = 0.01), were more likely to be of Hispanic ethnicity (p = 0.01), and had a history of chronic hypertension (p = 0.05), as well as higher occurrences of postpartum depression (p = 0.01), gestational diabetes (p = 0.05), cesarean section (CS) rates (p&lt; 0.001), and preeclampsia (p = 0.04). Among the infants reviewed, there was no statistical significance difference in developmental milestones at 2, 4, 6, 9, and 12 months of age between infants of parturients who tested positive for coronavirus disease 2019 (COVID-19) and infants of parturients without a positive COVID-19 test result. There was no statistically significant difference between the two groups in developmental outcomes, as measured by Ages and Stages Questionnaire (ASQ) scores at 9 months (p = 0.76) and at 18 months (p = 0.89). Conclusions: This study corroborates the adverse impact of SARS-CoV-2 infection on pregnant women, characterized by increased maternal comorbidities and adverse birth outcomes. No significant disparities in neonatal developmental milestones or growth outcomes were observed at birth; first office visit, or at 1, 2, 4, 6, 9, and 12 months of age.<\/jats:p>","DOI":"10.3390\/jcm14020420","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T08:03:05Z","timestamp":1736496185000},"page":"420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of COVID-19 on Neonatal Outcomes in a Community Hospital"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1289-8378","authenticated-orcid":false,"given":"Maria","family":"Martinez-Baladejo","sequence":"first","affiliation":[{"name":"Department of Research and Innovation, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3123-0867","authenticated-orcid":false,"given":"Yemesrach","family":"Kerego","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison R.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"},{"name":"Obstetrics and Gynecology Department, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Ohnona","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Scartelli","sequence":"additional","affiliation":[{"name":"Temple\/St. Luke\u2019s School of Medicine, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarke","family":"Stoltzfus","sequence":"additional","affiliation":[{"name":"Temple\/St. Luke\u2019s School of Medicine, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Graul","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Jacobetz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ng-Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, St. Luke\u2019s University Health Network, Bethlehem, PA 18015, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"ref_1","unstructured":"Gabbe, S.G., Niebyl, J.R., and Grobman, W.A. (2016). Obstetrics: Normal and Problem Pregnancies E-Book, Elsevier Health Sciences."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1080\/14767058.2021.1998440","article-title":"Comparison of early postnatal clinical outcomes of newborns born to pregnant women with COVID-19: A case-control study","volume":"35","year":"2022","journal-title":"J. Matern. Fetal. Neonatal Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"m3320","DOI":"10.1136\/bmj.m3320","article-title":"Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: Living systematic review and meta-analysis","volume":"370","author":"Allotey","year":"2020","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejogrb.2022.07.010","article-title":"Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study","volume":"276","author":"Mullins","year":"2022","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ciapponi, A., Bardach, A., Comand\u00e9, D., Berrueta, M., Argento, F.J., Rodriguez, C.F., Zamora, N., Santa, M.V., Xiong, X., and Zaraa, S. (2021). COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes. PLoS ONE, 16.","DOI":"10.1101\/2021.04.29.21256327"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e0007","DOI":"10.5041\/RMMJ.10464","article-title":"COVID-19 and Preeclampsia: Overlapping Features in Pregnancy","volume":"13","author":"Sathiya","year":"2022","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_7","first-page":"232","article-title":"Infections in Pregnancy","volume":"27","author":"Chan","year":"2017","journal-title":"Compr. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101427","DOI":"10.1016\/j.siny.2023.101427","article-title":"Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental outcomes","volume":"28","author":"Brum","year":"2023","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e2215787","DOI":"10.1001\/jamanetworkopen.2022.15787","article-title":"Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy","volume":"5","author":"Edlow","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ayed, M., Embaireeg, A., Kartam, M., More, K., Alqallaf, M., AlNafisi, A., Alsaffar, Z., Bahzad, Z., Buhamad, Y., and Alsayegh, H. (2022). Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: A national prospective study in Kuwait. BMC Pediatr., 22.","DOI":"10.1186\/s12887-022-03359-2"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/encyclopedia3010002","article-title":"Effects of in Utero SARS-CoV-2 Exposure on Newborn Health Outcomes","volume":"3","author":"Kyle","year":"2022","journal-title":"Encyclopedia"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Committee on Children with Disabilities (2001). Developmental surveillance and screening of infants and young children. Pediatrics, 108, 192\u2013195.","DOI":"10.1542\/peds.108.1.192"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1542\/pir.21.8.272","article-title":"Early detection of developmental and behavioral problems","volume":"21","author":"Glascoe","year":"2000","journal-title":"Pediatr. Rev."},{"key":"ref_14","unstructured":"Centers for Disease Control and Prevention (2024, November 11). COVID-19 Clinical Care Guidance, Available online: https:\/\/www.cdc.gov."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/AOG.0000000000004339","article-title":"Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)","volume":"137","author":"Metz","year":"2021","journal-title":"Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2021.04.019","article-title":"Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development","volume":"43","author":"Hoffman","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2439792","DOI":"10.1001\/jamanetworkopen.2024.39792","article-title":"In utero exposure to maternal COVID-19 and offspring neurodevelopment through age 24 months","volume":"7","author":"Jaswa","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: A review of findings from animal models","volume":"24","author":"Boksa","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wang, Y., Chen, L., Wu, T., Shi, H., Li, Q., Jiang, H., Zheng, D., Wang, X., Wei, Y., and Zhao, Y. (2020). Impact of Covid-19 in pregnancy on Mother\u2019s psychological status and infant\u2019s neurobehavioral development: A longitudinal cohort study in China. BMC Med., 18.","DOI":"10.1186\/s12916-020-01825-1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1001\/jama.2021.5775","article-title":"Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes","volume":"325","author":"Norman","year":"2021","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.33808\/clinexphealthsci.1102756","article-title":"The Assessment of Neurological Development of the Infants with Prenatal COVID-19 Exposure","volume":"13","author":"Nacar","year":"2023","journal-title":"Clin. Exp. Health Sci."},{"key":"ref_22","first-page":"1","article-title":"Developmental screening of full-term infants at 16 to 18 months of age after in-utero exposure to maternal SARS-CoV-2 infection","volume":"17","author":"Shah","year":"2023","journal-title":"J. Perinatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e069194","DOI":"10.1136\/bmjopen-2022-069194","article-title":"Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: A cohort study","volume":"13","author":"Martinez","year":"2023","journal-title":"BMJ Open"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/oby.23998","article-title":"Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection","volume":"32","author":"Shook","year":"2024","journal-title":"Obesity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1210\/clinem\/dgad130","article-title":"Accelerated Longitudinal Weight Gain Among Infants With In Utero COVID-19 Exposure","volume":"108","author":"Mollie","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.21037\/tp.2019.09.10","article-title":"Neurodevelopmental outcomes of preterm infants: A recent literature review","volume":"9","author":"Chung","year":"2020","journal-title":"Transl. Pediatr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e215563","DOI":"10.1001\/jamapediatrics.2021.5563","article-title":"Association of Birth during the COVID-19 Pandemic, but not maternal SARS-CoV-2 infection during pregnancy, is associated with lower neurodevelopmental scores at 6-months","volume":"176","author":"Shuffrey","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00737-018-0848-8","article-title":"Pregnancy in women with psychotic disorders: Risk factors associated with mother-baby separation","volume":"21","author":"Falissard","year":"2018","journal-title":"Arch. Womens Ment. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1651-2227.2012.02787.x","article-title":"Closeness and separation in neonatal intensive care","volume":"101","author":"Flacking","year":"2012","journal-title":"Acta Paediatr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Holdren, S., Fair, C., and Lehtonen, L. (2019). A qualitative cross-cultural analysis of NICU care culture and infant feeding in Finland and the U.S. BMC Pregnancy Childbirth, 19.","DOI":"10.1186\/s12884-019-2505-2"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s10578-021-01140-7","article-title":"COVID-19 threatens maternal mental health and infant development: Possible paths from stress and isolation to adverse outcomes and a call for research and practice","volume":"52","author":"Venta","year":"2021","journal-title":"Child Psychiatry Hum. 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