{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:37:45Z","timestamp":1759970265744,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaw Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Accurate and reproducible spleen volume measurements are essential for assessing treatment response and disease progression in myelofibrosis. This study evaluates techniques for measuring spleen volume on abdominal MRI. Methods: In 20 patients with bone marrow biopsy-proven myelofibrosis, 5 observers independently measured spleen volume on 3 abdominal MRI pulse sequences, 3D-spoiled gradient echo T1, axial single-shot fast spin echo (SSFSE) T2, and coronal SSFSE T2, using ellipsoidal approximation, manual contouring, and 3D nnU-Net model-assisted contouring comparing coefficients of variation. Changes in spleen volume were compared to all information to assess which measurement technique tracked disease progression with the greatest accuracy. Results: The coefficient of variation in spleen volume measurements averaging over 3 sequences was significantly lower for model-assisted contouring, 1.6% and manual contouring, 3.5%, compared to ellipsoidal estimation from 3 dimensions measured on axial and coronal T2 images, 15, p &lt; 0.001. In 4 subjects with divergent treatment response predictions, model-assisted contouring was consistent with all information while ellipsoidal estimation was not. Manual contouring tracked similarly to model-assisted contouring but required more operator time. Conclusions: Model-assisted segmentations provide efficient and more reproducible spleen volume measurements compared to estimates of spleen volume from ellipsoidal approximations and improve objective determinations of clinical trial enrollment eligibility based upon spleen volume as well as assessments of treatment response.<\/jats:p>","DOI":"10.3390\/jcm14020443","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:42:15Z","timestamp":1736750535000},"page":"443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Model-Assisted Spleen Contouring for Assessing Splenomegaly in Myelofibrosis: A Fast and Reproducible Approach to Evaluate Progression and Treatment Response"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7097-0032","authenticated-orcid":false,"given":"Arman","family":"Sharbatdaran","sequence":"first","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e9a","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-8350","authenticated-orcid":false,"given":"Hreedi","family":"Dev","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0114-3235","authenticated-orcid":false,"given":"Usama","family":"Sattar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Bazojoo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9258-5459","authenticated-orcid":false,"given":"Zhongxiu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6662-4908","authenticated-orcid":false,"given":"Chenglin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinzi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"},{"name":"Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-406X","authenticated-orcid":false,"given":"Dominick","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"},{"name":"Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-143X","authenticated-orcid":false,"given":"Joseph M.","family":"Scandura","sequence":"additional","affiliation":[{"name":"Richard T. Silver Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9883-0584","authenticated-orcid":false,"given":"Martin R.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, NY 10022, USA"},{"name":"Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1634\/theoncologist.2015-0094","article-title":"Fibrogenesis in Primary Myelofibrosis: Diagnostic, Clinical, and Therapeutic Implications","volume":"20","author":"Nazha","year":"2015","journal-title":"Oncologist"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3390\/tomography8040152","article-title":"Deep Learning Automation of Kidney, Liver, and Spleen Segmentation for Organ Volume Measurements in Autosomal Dominant Polycystic Kidney Disease","volume":"8","author":"Sharbatdaran","year":"2022","journal-title":"Tomography"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00277-020-04069-4","article-title":"Modern management of splenomegaly in patients with myelofibrosis","volume":"99","author":"Tremblay","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Song, M.K., Park, B.B., and Uhm, J.E. (2018). Understanding Splenomegaly in Myelofibrosis: Association with Molecular Pathogenesis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030898"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/S2352-3026(22)00330-1","article-title":"Splenomegaly in patients with primary or secondary myelofibrosis who are candidates for allogeneic hematopoietic cell transplantation: A Position Paper on behalf of the Chronic Malignancies Working Party of the EBMT","volume":"10","author":"Polverelli","year":"2023","journal-title":"Lancet Haematol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1200\/JCO.22.01972","article-title":"MANIFEST: Pelabresib in Combination with Ruxolitinib for Janus Kinase Inhibitor Treatment-Na\u00efve Myelofibrosis","volume":"41","author":"Mascarenhas","year":"2023","journal-title":"J. Clin. 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