{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:24:32Z","timestamp":1767705872958,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study presents a comprehensive analysis of 135 cases of vestibular schwannoma (VS) treated between 2006 and 2022 at the National Institute of Neurology and Neurovascular Diseases in Bucharest, Romania. The investigation focuses on the clinical presentation, treatment outcomes, and demographic trends of VS patients, highlighting region-specific insights that fill critical gaps in Eastern European data. Methods: Patients were treated with either open surgery (93.3%) or gamma knife radiosurgery (6.6%). The study identifies predominant symptoms, including hearing impairment, facial palsy, and balance disorders, with variations observed across age and gender subgroups. Comorbidities such as hypertension and obesity were prevalent, and they influenced perioperative risks. Results: Post-treatment outcomes showed a significant correlation between clinical symptoms and treatment modalities, with a majority achieving favorable results. The findings emphasize the need for tailored approaches in VS management and underscore the importance of region-specific factors in influencing clinical outcomes. Conclusions: This study contributes to refining treatment strategies and improving healthcare delivery for VS patients in Romania and beyond.<\/jats:p>","DOI":"10.3390\/jcm14020482","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T03:29:43Z","timestamp":1736825383000},"page":"482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Presentation, Treatment Outcomes, and Demographic Trends in Vestibular Schwannomas: A 135-Case Retrospective Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Corneliu","family":"Toader","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6320-177X","authenticated-orcid":false,"given":"Petrinel Mugurel","family":"R\u0103doi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena-Monica","family":"Ilie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan-Adrian","family":"Covache-Busuioc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad","family":"Buica","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca-Andrei","family":"Glavan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matei","family":"Serban","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9232-1176","authenticated-orcid":false,"given":"Antonio Daniel","family":"Corlatescu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Crivoi","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics and Computer Science, University of Bucharest, 050663 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu Mircea","family":"Gorgan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Neurosurgery, Bagdasar-Arseni Clinical Emergency Hospital, 041915 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","unstructured":"Kumar, V., Abbas, A.K., Aster, J.C., and Perkins, J.A. (2018). Robbins Basic Pathology, Elsevier. [10th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"vdaa153","DOI":"10.1093\/noajnl\/vdaa153","article-title":"New developments in neurofibromatosis type 2 and vestibular schwannoma","volume":"3","author":"Ren","year":"2021","journal-title":"Neuro-Oncol. Adv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"vdad099","DOI":"10.1093\/noajnl\/vdad099","article-title":"A systematic review of targeted therapy for vestibular schwannoma in patients with NF2-related schwannomatosis","volume":"5","author":"Chiranth","year":"2023","journal-title":"Neuro-Oncol. Adv."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/archotol.130.2.216","article-title":"What Is the Real Incidence of Vestibular Schwannoma?","volume":"130","author":"Tos","year":"2004","journal-title":"Arch. Otolaryngol. Neck Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00129492-200501000-00016","article-title":"Incidence of Vestibular Schwannoma and Neurofibromatosis 2 in the North West of England over a 10-year Period: Higher Incidence than Previously Thought","volume":"26","author":"Evans","year":"2005","journal-title":"Otol. Neurotol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12070-014-0736-0","article-title":"Role of Magnetic Resonance Imaging in Evaluation of Cerebellopontine Angle Schwannomas","volume":"67","author":"Singh","year":"2015","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2147\/CLEP.S218670","article-title":"Epidemiology Of Vestibular Schwannomas\u2014Prospective 40-Year Data From An Unselected National Cohort","volume":"11","author":"Reznitsky","year":"2019","journal-title":"Clin. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"098","DOI":"10.1055\/s-0036-1579766","article-title":"Neurofibromatosis: A Review of NF1, NF2, and Schwannomatosis","volume":"05","author":"Kresak","year":"2016","journal-title":"J. Pediatr. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Toader, C., Eva, L., Bratu, B.-G., Covache-Busuioc, R.-A., Costin, H.P., Dumitrascu, D.-I., Glavan, L.-A., Corlatescu, A.D., and Ciurea, A.V. (2023). Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights. Brain Sci., 13.","DOI":"10.3390\/brainsci13101454"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/14737175.2018.1399795","article-title":"An update on the diagnosis and treatment of vestibular schwannoma","volume":"18","author":"Halliday","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"ref_11","first-page":"1","article-title":"Management of 1000 Vestibular Schwannomas (Acoustic Neuromas): Clinical Presentation","volume":"40","author":"Matthies","year":"1997","journal-title":"Neurosurgery"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fortnum, H., O\u2019Neill, C., Taylor, R., Lenthall, R., Nikolopoulos, T., Lightfoot, G., O\u2019Donoghue, G., Mason, S., Baguley, D., and Jones, H. (2009). The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: A systematic review of clinical and cost effectiveness and natural history. Health Technol. Assess., 13.","DOI":"10.3310\/hta13180"},{"key":"ref_13","first-page":"593","article-title":"Risk factors associated with vestibulocochlear nerve schwannoma: Systematic review","volume":"75","author":"Corona","year":"2009","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1215\/15228517-2007-047","article-title":"Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck","volume":"10","author":"Schneider","year":"2008","journal-title":"Neuro-Oncology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.wneu.2015.07.007","article-title":"Epidemiology and Environmental Risk Factors Associated with Vestibular Schwannoma","volume":"84","author":"Berkowitz","year":"2015","journal-title":"World Neurosurg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1258\/0022215054273089","article-title":"Conservative management of sporadic unilateral acoustic neuromas","volume":"119","author":"Flint","year":"2005","journal-title":"J. Laryngol. Otol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s12105-020-01155-x","article-title":"Vestibular Schwannoma: What We Know and Where We are Heading","volume":"14","author":"Gupta","year":"2020","journal-title":"Head Neck Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3233\/VES-220022","article-title":"Regional differences in patient-reported outcomes as a proxy of healthcare practices for Americans living with vestibular symptoms","volume":"32","author":"Souza","year":"2022","journal-title":"J. Vestib. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/019459989010300307","article-title":"Estrogen and Progesterone Binding by Acoustic Neuroma Tissue","volume":"103","author":"Monsell","year":"1990","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2273.1995.tb00073.x","article-title":"Expression of steroid receptors in acoustic neuroma","volume":"20","author":"Filipo","year":"1995","journal-title":"Clin. Otolaryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0022215107000229","article-title":"Expression and clinical significance of Ki-67, oestrogen and progesterone receptors in acoustic neuroma","volume":"122","author":"Cafer","year":"2008","journal-title":"J. Laryngol. Otol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jaiswal, S., Agrawal, V., Jaiswal, A.K., Pandey, R., and Mahapatra, A.K. (2009). Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance. J. Negat. Results Biomed., 8.","DOI":"10.1186\/1477-5751-8-9"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Garrido-Cantero, G., Longo, F., Hern\u00e1ndez-Gonz\u00e1lez, J., Pueyo, \u00c1., Fern\u00e1ndez-Aparicio, T., Dorado, J.F., Angulo, J.C., and on behalf of the Madrid Cancer Registry (RTMAD) Investigators (2023). Impact of the COVID-19 Pandemic on Cancer Diagnosis in Madrid (Spain) Based on the RTMAD Tumor Registry (2019\u20132021). Cancers, 15.","DOI":"10.3390\/cancers15061753"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/01658107.2016.1183133","article-title":"Advanced Vestibular Schwannoma: A Case of Optic Disc Oedema without Hydrocephalus","volume":"40","author":"Matos","year":"2016","journal-title":"Neuro-Ophthalmology"},{"key":"ref_25","first-page":"e1862","article-title":"Vestibular Schwannoma Presenting with Bilateral Papilledema Without Hydrocephalus: Case Study","volume":"9","author":"Candanedo","year":"2017","journal-title":"Cureus"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/02688697.2022.2039376","article-title":"Systematic scoping review of papilledema in vestibular schwannoma without hydrocephalus","volume":"37","author":"Mishra","year":"2023","journal-title":"Br. J. Neurosurg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"106192","DOI":"10.1016\/j.clineuro.2020.106192","article-title":"The association of age, body mass index, and frailty with vestibular schwannoma surgical morbidity","volume":"197","author":"Goshtasbi","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.3171\/2012.6.FOCUS12163","article-title":"Surgery for vestibular schwannomas: A systematic review of complications by approach","volume":"33","author":"Ansari","year":"2012","journal-title":"Neurosurg. Focus"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3171\/jns.1998.88.3.0506","article-title":"Neurotopographic considerations in the microsurgical treatment of small acoustic neurinomas","volume":"88","author":"Koos","year":"1998","journal-title":"J. Neurosurg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/neuros\/nyy409","article-title":"Koos Classification of Vestibular Schwannomas: A Reliability Study","volume":"85","author":"Erickson","year":"2019","journal-title":"Neurosurgery"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E523","DOI":"10.1093\/neuros\/nyab086","article-title":"The Validity of the Koos Classification System With Respect to Facial Nerve Function","volume":"88","author":"Erickson","year":"2021","journal-title":"Neurosurgery"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/482\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:28:15Z","timestamp":1759919295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14020482"],"URL":"https:\/\/doi.org\/10.3390\/jcm14020482","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,1,14]]}}}