{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:32:44Z","timestamp":1789569164841,"version":"build-2803163510"},"reference-count":19,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The lactate dehydrogenase to albumin ratio (LAR) is a novel inflammatory marker and a potential predictor of mortality in various conditions. No research has yet examined LAR\u2019s impact on mortality in cardiac surgery patients. This study evaluated LAR\u2019s role in predicting mortality and complications in isolated coronary artery bypass grafting (CABG) patients. Methods: A retrospective analysis of 377 CABG patients (93 women, 24.7%; 284 men, 75.3%; mean age 65.9 years) from 2020 to 2024 was conducted. Data included demographics, preoperative characteristics, surgical details, and postoperative outcomes, along with ICU and hospital length of stay (LOS). Results: In-hospital mortality was 6.1% (n = 23). Independent predictors were low preoperative ejection fraction (EF) (OR: 0.96, p = 0.024), baseline LAR (OR: 1.08, p = 0.000), LOS-ICU (OR: 1.1, p = 0.000), postoperative ventricular tachycardia (OR: 37.9, p = 0.006), and acute renal failure (OR: 12.1, p = 0.000). Mortality cases had a higher median LAR than survivors (8.6 vs. 5.2, p = 0.000). Elevated LAR correlated with lower preoperative EF (r = \u22120.227, p = 0.000), longer LOS-ICU (r = 0.17, p = 0.001), and longer LOS-hospital (r = 0.208, p = 0.000). A LAR cut-off of 7.097 predicted mortality (AUC: 0.823, sensitivity 78.3%, specificity 77.1%). Elevated LAR values were observed in all groups with postoperative complications (p &lt; 0.05), indicating its consistent association with negative outcomes. Conclusions: LAR is a valuable predictor of in-hospital mortality and postoperative complications in CABG patients. Elevated LAR is associated with longer ICU\/hospital stays and poorer outcomes. Preoperative LAR assessment can guide risk stratification, forecast mortality, and inform surgical planning and treatment strategies.<\/jats:p>","DOI":"10.3390\/jcm14020554","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:46:10Z","timestamp":1737009970000},"page":"554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessing the Predictive Impact of Preoperative Lactate Dehydrogenase to Albumin Ratio on Outcomes Following Coronary Artery Bypass Graft Surgery"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-4709","authenticated-orcid":false,"given":"Ozgur","family":"Baris","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-2463","authenticated-orcid":false,"given":"Canbolat","family":"Holat","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-1013","authenticated-orcid":false,"given":"Mustafa","family":"Tosun","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulviye","family":"Yaman","sequence":"additional","affiliation":[{"name":"School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-4361","authenticated-orcid":false,"given":"Aysegul","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-4525","authenticated-orcid":false,"given":"Mustafa","family":"Canikoglu","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Omay","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-5531","authenticated-orcid":false,"given":"Sadan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli 41001, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/heart.89.7.767","article-title":"Adverse events in coronary artery bypass graft (CABG) trials: A systematic review and analysis","volume":"89","author":"Nalysnyk","year":"2003","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e27560","DOI":"10.1016\/j.heliyon.2024.e27560","article-title":"The relationship between lactate dehydrogenase to albumin ratio and all-cause mortality during ICU stays in patients with sepsis: A retrospective cohort study with propensity score matching","volume":"10","author":"Guan","year":"2024","journal-title":"Heliyon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.7754\/Clin.Lab.2022.220915","article-title":"Association between Lactate Dehydrogenase and 30-Day Mortality in Patients with Sepsis: A Retrospective Cohort Study","volume":"69","author":"Liu","year":"2023","journal-title":"Clin. Lab."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zeng, Y., Zhao, Y., Dai, S., Liu, Y., Zhang, R., Yan, H., Zhao, M., and Wang, Y. (2022). Impact of lactate dehydrogenase on prognosis of patients undergoing cardiac surgery. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02848-7"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jin, X., Li, J., Sun, L., Zhang, J., Gao, Y., Li, R., Ren, J., Hou, Y., Su, D., and Liu, J. (2022). Prognostic Value of Serum Albumin Level in Critically Ill Patients: Observational Data From Large Intensive Care Unit Databases. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.770674"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00595-022-02566-9","article-title":"Preoperative hypoalbuminemia in patients undergoing cardiac surgery: A meta-analysis","volume":"53","author":"Xu","year":"2023","journal-title":"Surg. Today"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shu, X.P., Xiang, Y.C., Liu, F., Cheng, Y., Zhang, W., and Peng, D. (2023). Effect of serum lactate dehydrogenase-to-albumin ratio (LAR) on the short-term outcomes and long-term prognosis of colorectal cancer after radical surgery. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11446-5"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.2147\/JIR.S472041","article-title":"Effect of Preoperative Serum Lactate Dehydrogenase-to-Albumin Ratio on the Survival of Oral Cancer: A Retrospective Study","volume":"17","author":"Wang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ajem.2021.11.028","article-title":"Lactate dehydrogenase to albumin ratio as a prognostic factor in lower respiratory tract infection patients","volume":"52","author":"Lee","year":"2022","journal-title":"Am. J. Emerg. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e27538","DOI":"10.1097\/MD.0000000000027538","article-title":"Lactate dehydrogenase to albumin ratio as a prognostic factor for patients with severe infection requiring intensive care","volume":"100","author":"Jeon","year":"2021","journal-title":"Medicine"},{"key":"ref_11","first-page":"e63","article-title":"Lactate Dehydrogenase to Albumin ratio as a Predictive Factor of COVID-19 Patients\u2019 Outcome; a Cross-Sectional Study","volume":"10","author":"Alizadeh","year":"2022","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2212080","DOI":"10.1080\/0886022X.2023.2212080","article-title":"The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: A retrospective cohort study","volume":"45","author":"Liang","year":"2023","journal-title":"Ren. Fail."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.21037\/jtd-23-1238","article-title":"Prognostic value of lactic dehydrogenase-to-albumin ratio in critically ill patients with acute respiratory distress syndrome: A retrospective cohort study","volume":"16","author":"Zhang","year":"2024","journal-title":"J. Thorac. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejim.2022.05.004","article-title":"Low serum albumin: A neglected predictor in patients with cardiovascular disease","volume":"102","author":"Manolis","year":"2022","journal-title":"Eur. J. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhu, L., Chen, M., and Lin, X. (2020). Serum albumin level for prediction of all-cause mortality in acute coronary syndrome patients: A meta-analysis. Biosci. Rep., 40.","DOI":"10.1042\/BSR20190881"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E123","DOI":"10.1532\/hsf.1577","article-title":"Preoperative Low Serum Albumin Levels Increase the Requirement of Renal Replacement Therapy after Cardiac Surgery","volume":"19","author":"Findik","year":"2016","journal-title":"Heart Surg. Forum"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s13019-023-02406-y","article-title":"Hemolysis and cardiopulmonary bypass: Meta-analysis and systematic review of contributing factors","volume":"18","author":"Bhirowo","year":"2023","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hu, J., and Zhou, Y. (2024). The association between lactate dehydrogenase to serum albumin ratio and in-hospital mortality in patients with pulmonary embolism: A retrospective analysis of the MIMIC-IV database. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1398614"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chen, S., Guan, S., Yan, Z., Ouyang, F., Li, S., Liu, L., and Zhong, J. (2023). The lactate to albumin ratio linked to all-cause mortality in critically ill patients with septic myocardial injury. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1233147"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/554\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:29:58Z","timestamp":1759919398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/2\/554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcm14020554"],"URL":"https:\/\/doi.org\/10.3390\/jcm14020554","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]}}}