{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:39:18Z","timestamp":1759970358346,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: To report the cosmetic, clinical, and visual outcomes of a combined surgical approach for treating a corneal\/limbal dermoid using excision and a three-layered amniotic membrane graft with fibrin glue. Methods: An 18-year-old female presented with impaired vision and ocular discomfort caused by a prominent dome-shaped limbal congenital dermoid on the inferotemporal cornea, resulting in a significant aesthetic concern. A full assessment, including refraction, best-corrected visual acuity (BCVA), corneal topography, aberrometry and anterior segment OCT (AS-OCT) was conducted to plan the surgical approach. The dermoid was excised under peribulbar anaesthesia using manual lamellar dissection, followed by the application of 0.02% Mitomycin C and a multilayered amniotic membrane graft with fibrin glue. A bandage contact lens was applied and removed after three weeks, with postoperative treatment including topical antibiotics and steroids. Follow-ups were conducted on day 1, at 1 week, 3 weeks, 2 months, 6 months, 1 year, and 2 years. Results: Histopathological examination confirmed the mesoblastic nature of the lesion. Significant improvements in BCVA and ocular symptoms were observed. Corneal topography showed ocular surface regularization with reduction of high order aberrations and point spread function. AS-OCT showed complete integration of the amniotic membrane, with full epithelial coverage of the defect. The healing process was uneventful and the ocular surface remained stable throughout the entire follow-up, without complications or recurrence. Conclusions: This approach of dermoid excision, multilayered amniotic membrane and fibrin glue restored vision effectively, with notable improvements in ocular surface and cosmetic outcomes, without recurrence over two years.<\/jats:p>","DOI":"10.3390\/jcm14020607","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T10:32:15Z","timestamp":1737369135000},"page":"607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combined Multilayered Amniotic Membrane Graft and Fibrin Glue as a Surgical Management of Limbal Dermoid Cyst"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2403-9528","authenticated-orcid":false,"given":"Maria","family":"Poddi","sequence":"first","affiliation":[{"name":"Ophthalmology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Romano","sequence":"additional","affiliation":[{"name":"Eye Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Viale Europa 15, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Borgia","sequence":"additional","affiliation":[{"name":"Cornea Unit, Mons. Dimiccoli Hospital, 70051 Barletta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriana","family":"Porcaro","sequence":"additional","affiliation":[{"name":"Consorzio Sannio Tech, 82030 Apollosa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-9219","authenticated-orcid":false,"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Messina","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/ICO.0000000000000440","article-title":"New surgical approach for limbal dermoids in children: Simple excision, corneal tattooing, and sutureless limboconjunctival autograft","volume":"34","author":"Jeong","year":"2015","journal-title":"Cornea"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/ICL.0b013e31824828ee","article-title":"Ocular dermoids: 116 consecutive cases","volume":"39","author":"Navas","year":"2013","journal-title":"Eye Contact Lens"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/11206721221111880","article-title":"Visual and surgical outcomes of limbal dermoid excision at a tertiary care eye hospital","volume":"33","author":"AlGhadeer","year":"2023","journal-title":"Eur. 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