{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:17:40Z","timestamp":1787872660140,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Pulmonary arterial hypertension (PAH) is a complication of systemic sclerosis (SSc), and several screening algorithms have been proposed for the early detection of PAH in SSc. This study aimed to evaluate the predicting values of the DETECT algorithm for SSc-PAH screening in patients with SSc undergoing right heart catheterization (RHC) based on 2015 ESC\/ERS echocardiographic criteria in a real-life setting. Methods: Patients fulfilling the 2013 ACR\/EULAR classification criteria for SSc and with available data for PAH screening with the DETECT algorithm and the 2015 ESC\/ERS echocardiographic criteria were retrospectively enrolled from January to June 2017 and then followed for 5 years. Baseline and annual clinical, laboratory, and instrumental data were collected. Results: A total of 33 out of 131 (25%) patients were selected based upon the ESC\/ERS echocardiographic criteria, but 30 (23%) underwent RHC, while 51 (39%) patients with SSc were positive based on the DETECT algorithm. PAH diagnosis was confirmed in 28\/30 cases (93.3%). The DETECT algorithm showed lower specificity and positive predictive value (PPV) (p &lt; 0.0001) but higher sensitivity and negative predictive value (NPV) (p &lt; 0.0001) than ESC\/ERS criteria. Notably, patients with SSc with a negative DETECT screening at baseline had a low probability of developing PAH during a 5-year follow-up (OR 0.15, 95% CI 0.10\u20130.60\u2014p &lt; 0.0001). Conclusions: The DETECT algorithm has proven to be an easy, fast, and inexpensive tool for screening PAH in patients with SSc. Overall, a low probability of PAH using DETECT is highly predictive of a good prognosis.<\/jats:p>","DOI":"10.3390\/jcm14020638","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T12:32:52Z","timestamp":1737376372000},"page":"638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive Value of the DETECT Algorithm for Pulmonary Arterial Hypertension in Systemic Sclerosis: Findings from an Italian Observational Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Stefano","family":"Stano","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine Jonian Area (DiPReMeJ), University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5686-0127","authenticated-orcid":false,"given":"Claudia","family":"Iannone","sequence":"additional","affiliation":[{"name":"Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Division of Hospital Cardiology, Cardiothoracic Department, Policlinico University Hospital, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Pellico","sequence":"additional","affiliation":[{"name":"Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Urso","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine Jonian Area (DiPReMeJ), University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Del Papa","sequence":"additional","affiliation":[{"name":"Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Caporali","sequence":"additional","affiliation":[{"name":"Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-4462","authenticated-orcid":false,"given":"Fabio","family":"Cacciapaglia","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine Jonian Area (DiPReMeJ), University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"},{"name":"Rheumatology Service, Internal Medicine Unit \u201cF. Miulli\u201d General Hospital, Acquaviva delle Fonti, 70021 Bari, Italy"},{"name":"Department of Medicine and Surgery, LUM \u2019G. De Gennaro\u2019, Casamassima, 70010 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/ard.2006.066068","article-title":"Changes in causes of death in systemic sclerosis, 1972\u20132002","volume":"66","author":"Steen","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Boutel, M., Dara, A., Arvanitaki, A., Deuteraiou, C., Mytilinaiou, M., and Dimitroulas, T. (2024). 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