{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:32:22Z","timestamp":1787884342483,"version":"build-2784847793"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471042"],"award-info":[{"award-number":["82471042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24ZR1409600"],"award-info":[{"award-number":["24ZR1409600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GWVI-11.1-32"],"award-info":[{"award-number":["GWVI-11.1-32"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["23Y11901100"],"award-info":[{"award-number":["23Y11901100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shanghai","award":["82471042"],"award-info":[{"award-number":["82471042"]}]},{"name":"Natural Science Foundation of Shanghai","award":["24ZR1409600"],"award-info":[{"award-number":["24ZR1409600"]}]},{"name":"Natural Science Foundation of Shanghai","award":["GWVI-11.1-32"],"award-info":[{"award-number":["GWVI-11.1-32"]}]},{"name":"Natural Science Foundation of Shanghai","award":["23Y11901100"],"award-info":[{"award-number":["23Y11901100"]}]},{"name":"Key Discipline Program of the Sixth Round of the Three-Year Public Health Action Plan (Year 2023\u20132025) of Shanghai, China","award":["82471042"],"award-info":[{"award-number":["82471042"]}]},{"name":"Key Discipline Program of the Sixth Round of the Three-Year Public Health Action Plan (Year 2023\u20132025) of Shanghai, China","award":["24ZR1409600"],"award-info":[{"award-number":["24ZR1409600"]}]},{"name":"Key Discipline Program of the Sixth Round of the Three-Year Public Health Action Plan (Year 2023\u20132025) of Shanghai, China","award":["GWVI-11.1-32"],"award-info":[{"award-number":["GWVI-11.1-32"]}]},{"name":"Key Discipline Program of the Sixth Round of the Three-Year Public Health Action Plan (Year 2023\u20132025) of Shanghai, China","award":["23Y11901100"],"award-info":[{"award-number":["23Y11901100"]}]},{"name":"Shanghai Commission of Science and Technology","award":["82471042"],"award-info":[{"award-number":["82471042"]}]},{"name":"Shanghai Commission of Science and Technology","award":["24ZR1409600"],"award-info":[{"award-number":["24ZR1409600"]}]},{"name":"Shanghai Commission of Science and Technology","award":["GWVI-11.1-32"],"award-info":[{"award-number":["GWVI-11.1-32"]}]},{"name":"Shanghai Commission of Science and Technology","award":["23Y11901100"],"award-info":[{"award-number":["23Y11901100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Scleral lenses (SLs) are recommended in DEWS II to treat dry eye (DE) patients that do not respond well to conventional therapies. This study aimed to evaluate the short-term (one month) efficacy and safety of SLs in the management of severe DE. Methods: This single-center prospective study enrolled 15 patients (22 eyes) who were diagnosed with severe DE. The Ocular Surface Disease Index (OSDI), the Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (CHI-VFQ-25), and LogMAR best-corrected visual acuity (BCVA) were evaluated at baseline and one month following SL fitting. DE-related parameters were obtained and analyzed before and after one month of SL treatment, including tear-film breakup time (TBUT), corneal fluorescein staining (CFS), non-invasive breakup time (NIBUT), tear meniscus height (TMH), Schirmer I test (SIT), and meibomian gland (MG) dropout. Complications and adverse events were monitored. Results: OSDI scores (53.9 \u00b1 28.1 vs. 10.4 (4.2\u201325), p = 0.0001) and CFS scores (10.2 \u00b1 3.9 vs. 7 (0\u201312), p = 0.001) decreased after one month of SL therapy, while CHI-VFQ-25 scores (74.4 (54.8\u201383.8) vs. 95 (78.7\u201398), p = 0.0001) and TBUT (0.6 \u00b1 0.5 vs. 2.2 \u00b1 1.0, p &lt; 0.0001) increased significantly. LogMAR BCVA improved from 0 (0\u20130.1) to 0 (0\u20130) (p = 0.0147). The average types of medications per eye decreased from 2.82 \u00b1 1.01 to 1.32 \u00b1 0.64 (p = 0.025), and the proportion of eyes using glucocorticoids significantly decreased from 63.6% to 13.6% (p = 0.001). No severe SL-related adverse events were reported. Conclusions: SL treatment quickly alleviated subjective symptoms as well as clinical signs of DE with good safety and enhanced the visual function and vision-related quality of life, showing its usefulness in the management of severe DE.<\/jats:p>","DOI":"10.3390\/jcm14030658","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:47:42Z","timestamp":1737438462000},"page":"658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short-Term Efficacy and Safety of Scleral Lenses in the Management of Severe Dry Eye in a Chinese Population"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5012-4855","authenticated-orcid":false,"given":"Chuwei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danjie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China"},{"name":"Shanghai Engineering Research Center of Synthetic Immunology, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China"},{"name":"Shanghai Engineering Research Center of Synthetic Immunology, Shanghai 200032, China"},{"name":"Department of Ophthalmology, Children\u2019s Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daddi","family":"Fadel","sequence":"additional","affiliation":[{"name":"Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China"},{"name":"Shanghai Engineering Research Center of Synthetic Immunology, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-3101","authenticated-orcid":false,"given":"Qihua","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China"},{"name":"NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. 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