{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:49:06Z","timestamp":1783118946758,"version":"3.54.6"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Central serous chorioretinopathy (CSCR) is a common retinopathy that can present with other concurrent diseases; thus, further research into the prevalence of other ocular comorbidities in eyes with CSCR is required. Methods: This retrospective, multicentric, cross-sectional observational study reviewed the charts of 9157 patients. Of them, 579 (6.32%) patients and 766 eyes had an additional ocular comorbidity, in addition to CSCR, in at least one subject eye. Results: The baseline best-corrected visual acuity (BCVA) of the subjects eyes was 0.49 \u00b1 0.36 logMAR. The average BCVA of subject eyes with coexisting macular diseases was 0.50 logMAR, while the corresponding BCVA of subject eyes with coexisting peripheral disease was 0.55 logMAR. The most prevalent coexisting macular diseases were non-proliferative diabetic retinopathy (26.8%), non-exudative age-related macular degeneration (AMD) (7.6%) and hypertensive retinopathy (3.0%). The most prevalent coexisting non-macular diseases were lattice degeneration (8.9%), optic atrophy (5.1%), rhegmatogenous retinal detachment (1.70%) and optic disc pit (1.7%). The odds of having a comorbid disease in the same eye as CSCR were statistically significant for branch retinal vein occlusion (OR 11.56, p-value = 0.02) and non-exudative AMD (OR 2.06; p-value = 0.01); additionally, there was a trend towards significance for idiopathic polypoidal choroidal vasculopathy (OR 4.43; p-value = 0.05) when compared to the eyes without CSCR. Conclusions: Certain diseases are more likely to coexist in eyes with CSCR. Additionally, eyes with CSCR may have statistically significant odds of certain diseases when compared to eyes without CSCR.<\/jats:p>","DOI":"10.3390\/jcm14030720","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:49:54Z","timestamp":1737611394000},"page":"720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Central Serous Chorioretinopathy and Ocular Comorbidities"],"prefix":"10.3390","volume":"14","author":[{"given":"Anindya","family":"Samanta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Driban","sequence":"additional","affiliation":[{"name":"UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-2507","authenticated-orcid":false,"given":"Niroj","family":"Sahoo","sequence":"additional","affiliation":[{"name":"LV Prasade Eye Institute, Kallam Anji Reddy Campus, LV Prasad Marg, opp. PVR, Park View Enclave, Banjara Hills, Hyderabad 500034, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Parameswarappa","sequence":"additional","affiliation":[{"name":"LV Prasade Eye Institute, Kallam Anji Reddy Campus, LV Prasad Marg, opp. PVR, Park View Enclave, Banjara Hills, Hyderabad 500034, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-5343","authenticated-orcid":false,"given":"Sumit Randhir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Vitreoretina, Akhand Jyoti Eye Hospital, CoE Mastichak, Saran 841219, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonny","family":"Caplash","sequence":"additional","affiliation":[{"name":"UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranjal","family":"Mishra","sequence":"additional","affiliation":[{"name":"Narayana Nethralaya, 121\/C Chord Road, 1st \u2018R\u2019 Block, Rajaji Nagar, Bangalore 560010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-876X","authenticated-orcid":false,"given":"Rohit","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Narayana Nethralaya, 121\/C Chord Road, 1st \u2018R\u2019 Block, Rajaji Nagar, Bangalore 560010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4479-9390","authenticated-orcid":false,"given":"Ramesh","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Narayana Nethralaya, 121\/C Chord Road, 1st \u2018R\u2019 Block, Rajaji Nagar, Bangalore 560010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-3982","authenticated-orcid":false,"given":"Dmitrii S.","family":"Maltsev","sequence":"additional","affiliation":[{"name":"Military Medical Academy, 21, Botkinskaya Str., St. Petersburg 194044, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-3558","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.survophthal.2012.12.001","article-title":"Optical Coherence Tomography: Imaging of the Choroid and Beyond","volume":"58","author":"Mrejen","year":"2013","journal-title":"Surv. 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