{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:44:22Z","timestamp":1759970662530,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biohit Oyj (Helsinki, Finland) as part of their R &amp; D project of the novel GPQT test"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Increased demand of the serological biomarker test (GastroPanel\u00ae) in non-invasive diagnosis of gastric cancer (GC) risk conditions, i.e., atrophic gastritis (AG) and Helicobacter pylori (Hp) infection, prompted the design of GastroPanel\u00ae Quick test (GPQT) (Biohit Oyj, Helsinki, Finland) for point-of-care (POC) settings. Objective: This study validated the diagnostic accuracy (DA) of GPQT in diagnosis of AG and Hp among gastroscopy referral patients. Methods: Altogether, 266 patients were enrolled among the consecutive gastroscopy referrals at the Department of Gastroenterology, Fortis Hospital (Punjab, India). All patients underwent gastroscopy with biopsies (n = 249) classified using the Updated Sydney System (USS) and finger prick blood sampling for GPQT testing. Results: Biopsy-confirmed AG was found in 15.3% (38\/249) of the patients. The overall agreement between the GPQT and the USS classification was 71.4% (95% CI 65.4\u201377.0%), with the weighted kappa (\u03baw) of 0.823 (95% CI 0.773\u20130.862). In ROC analysis for moderate\/severe AG of the corpus (AGC) endpoint, AUC = 0.990 (95% CI 0.979\u20131.000) and AUC = 0.971 (95% CI 0.948\u20130.995) for PGI and PGI\/PGII, respectively. Hp IgG Ab test detected biopsy-confirmed Hp with AUC = 0.836 (95% CI 0.783\u20130.889). Conclusions: The GPQT favourably competes in accuracy with the ELISA test version (unified-GP) in diagnosis of AG and Hp in patients referred for diagnostic gastroscopy.<\/jats:p>","DOI":"10.3390\/jcm14030787","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T07:54:08Z","timestamp":1738050848000},"page":"787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Point-of-Care Diagnosis of Atrophic Gastritis by Serological Biomarker Test (GastroPanel\u00ae Quick Test) in Gastroscopy Referral Patients in India"],"prefix":"10.3390","volume":"14","author":[{"given":"Mohinish","family":"Chhabra","sequence":"first","affiliation":[{"name":"GI Physiology and Motility Laboratory, Department of Gastroenterology, Fortis Hospital and Research Centre, Sector 62, Lamba, Sahibzada Ajit Singh Nagar 160062, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-6940","authenticated-orcid":false,"given":"Ajit","family":"Kolatkar","sequence":"additional","affiliation":[{"name":"GastroLab India Pvt Ltd., 202, Specialy Business Centre, Balewadi Rd, Balewadi, Pune 411045, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Chawla","sequence":"additional","affiliation":[{"name":"GI Physiology and Motility Laboratory, Department of Gastroenterology, Fortis Hospital and Research Centre, Sector 62, Lamba, Sahibzada Ajit Singh Nagar 160062, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4661-7638","authenticated-orcid":false,"given":"Aniket","family":"Joshi","sequence":"additional","affiliation":[{"name":"GastroLab India Pvt Ltd., 202, Specialy Business Centre, Balewadi Rd, Balewadi, Pune 411045, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Biohit Oyj, 00880 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Holopainen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Biohit Oyj, 00880 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panu","family":"Hendolin","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Biohit Oyj, 00880 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7180-7491","authenticated-orcid":false,"given":"Kari","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"SMW Consultants, Ltd., Kylli\u00e4isentie 9, 21620 Kaarina, Finland"},{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos CEP 14784-400, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref_2","first-page":"4737","article-title":"Gastric precancerous process in a high-risk population: Cohort follow-up","volume":"50","author":"Correa","year":"1990","journal-title":"Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall","year":"1984","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0889-8553(05)70131-X","article-title":"Gastritis and gastric cancer. 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