{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:06:59Z","timestamp":1790957219571,"version":"4.1.0"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Perfusion strategy is crucial for the outcome of neonatal aortic arch surgery. This study investigates Whole-Body Perfusion to potentially improve postoperative outcomes for neonates, addressing a significant gap in current research. Methods: Retrospective analysis was conducted for neonates receiving aortic arch reconstruction in our institution: 33 patients were treated with Antegrade Cerebral Perfusion (ACP, 2014\u20132017) and 61 patients with Whole-Body Perfusion (WBP, 2017\u20132022). After strict Propensity Score Matching, 20 patients were analyzed in each group. WBP consists of ACP and Lower Body Perfusion (LBP), achieved through a femoral arterial sheath. Results: Patients with WBP had a shorter time on Cardiopulmonary Bypass (86.65 \u00b1 25.47 vs. 172.95 \u00b1 60.12 min) and Cross-Clamp time (46.70 \u00b1 18.48 vs. 91.30 \u00b1 40.10 min) (p \u2264 0.001). Lactate at the time of reperfusion and after 24 h was lower in the WBP group (1.73 \u00b1 0.63 vs. 4.29 \u00b1 1.61, p &lt; 0.001; 1.45 \u00b1 0.57 vs. 2.09 \u00b1 0.96 mmol\/L, p = 0.026). Patients with WBP needed significantly fewer intraoperative transfusions of Red Blood Cells, Fresh Frozen Plasma and Platelets (p \u2264 0.001). WBP patients had a shorter time on ventilator (5.15 \u00b1 4.05 vs. 10.00 \u00b1 8.72 days, p = 0.01) and a higher urine output after 24 h (200.85 \u00b1 100.87 vs. 118.10 \u00b1 82.33 mL, p = 0.002). Conclusions: Patients treated with WBP received significantly fewer intraoperative transfusions and had a shorter time on extracorporeal circulation and ventilator. Furthermore, there was a trend for reduced multiorgan dysfunction.<\/jats:p>","DOI":"10.3390\/jcm14030843","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T08:57:48Z","timestamp":1738054668000},"page":"843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 6-Year Single Center Experience in Neonatal Aortic Arch Surgery with Whole-Body Perfusion: Showing the Perks by Strict Propensity Score Matching"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8068-7253","authenticated-orcid":false,"given":"Isabelle","family":"Doll","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-7020","authenticated-orcid":false,"given":"Rodrigo","family":"Sandoval Boburg","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-4457","authenticated-orcid":false,"given":"Rafal","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-8397","authenticated-orcid":false,"given":"Christian J\u00f6rg","family":"Rustenbach","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-4724","authenticated-orcid":false,"given":"J\u00f6rg","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Intensive Care Medicine, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-6399","authenticated-orcid":false,"given":"Harry","family":"Magunia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schlensak","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital T\u00fcbingen, Eberhard-Karls-University T\u00fcbingen, Hoppe-Seyler-Str. 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jtcvs.2010.03.034","article-title":"Acute kidney injury and regional abdominal perfusion during neonatal aortic arch reconstruction","volume":"140","author":"Rajagopal","year":"2010","journal-title":"J. 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