{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:52:38Z","timestamp":1773352358739,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Thrombocytopenia, defined as a platelet count below 150 \u00d7 109\/L, is the second most common hematological abnormality after anemia found among European women in the third trimester of pregnancy. Most of the cases are mild, asymptomatic, and diagnosed accidentally. The primary causes of thrombocytopenia are linked to the pregnancy itself and include gestational thrombocytopenia (GT), autoimmune thrombocytopenia (ITP), and pre-eclampsia or HELLP syndrome-associated thrombocytopenia. First-line therapies for ITP include corticosteroids and intravenous immunoglobulin (IVIG). We came across a case of severe thrombocytopenia (platelet count of 9 \u00d7 109\/L) associated with severe anemia (Hb 5.9 g\/dL) at 30 weeks of gestation, with no personal or family history of bleeding disorders. A comprehensive hematologic, infectious, and rheumatological workup was performed to narrow the diagnosis. Despite aggressive corticosteroid therapy and immunoglobulin treatment, the patient\u2019s thrombocytopenia persisted, imposing delivery at 34 weeks. This article highlights the complex presentation and management of severe thrombocytopenia and anemia during pregnancy.<\/jats:p>","DOI":"10.3390\/jcm14030872","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T10:44:30Z","timestamp":1738061070000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-9348","authenticated-orcid":false,"given":"Andrei Mihai","family":"Malutan","sequence":"first","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Teodora","family":"Pascu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doru","family":"Diculescu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan","family":"Ciortea","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia","family":"Blaga","sequence":"additional","affiliation":[{"name":"Department of Neonatology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Nicula","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Bucuri","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"},{"name":"Clinical Department of Surgery, \u201cConstantin Papilian\u201d Emergency Clinical Military Hospital, 22 G-ral Traian Mosoiu, 400132 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Roman","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-3682","authenticated-orcid":false,"given":"Ionel","family":"Nati","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Mihaela","family":"Ormindean","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1909-7367","authenticated-orcid":false,"given":"Viorela","family":"Suciu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mihu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u2018Iuliu Hatieganu\u2019 University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1182\/bloodadvances.2023012541","article-title":"The 2022 review of the 2019 American Society of Hematology guidelines on immune thrombocytopenia","volume":"8","author":"Neunert","year":"2024","journal-title":"Blood Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1182\/blood-2010-08-302984","article-title":"The American Society of Hematology 2011 evidence-based practice guideline for immune 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