{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:44:20Z","timestamp":1789523060134,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cRicerca Corrente\u201d funding program of the Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Nasal cytology is a non-invasive, affordable, and easily executable technique commonly used in research to study rhinitis and, to a lesser extent, chronic rhinosinusitis. It is particularly useful for the differential diagnosis of non-allergic rhinitis and for phenotyping chronic rhinosinusitis. Allergic rhinitis, asthma, and aspirin intolerance are frequent comorbidities of chronic rhinosinusitis. A diagnostic system has been proposed to assess the severity of chronic rhinosinusitis (clinical-cytological grading), incorporating nasal cytology and comorbidity observation. This score correlates with the recurrence risk of chronic rhinosinusitis with nasal polyposis. Specifically, a higher grade is often linked to asthma, aspirin intolerance, a recurrent disease requiring surgery, and a mixed cell phenotype (eosinophilic and mast cell). Although nasal cytology has been shown to be able to replace bronchial analysis with acceptable precision due to its technical characteristics, its use in diseases affecting both upper and lower airways remains limited. The main limitation of this technique is its lack of standardization, which currently hinders its widespread clinical adoption despite its increasing familiarity among allergists and otolaryngologists. In the context of the unitary airways hypothesis, nasal cytology could also provide valuable insights for managing lower airway diseases like chronic obstructive pulmonary disease and obstructive sleep apnea syndrome, which significantly impact quality of life and healthcare costs. This review aims to provide an overview of nasal cytology, highlighting its limitations and potential applications in chronic respiratory diseases.<\/jats:p>","DOI":"10.3390\/jcm14030884","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T03:26:10Z","timestamp":1738121170000},"page":"884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Potential Role of Nasal Cytology in Respiratory Diseases: Clinical Research and Future Perspectives"],"prefix":"10.3390","volume":"14","author":[{"given":"Giuseppina","family":"Marcuccio","sequence":"first","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4450-2605","authenticated-orcid":false,"given":"Giuseppina","family":"Raffio","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-0428","authenticated-orcid":false,"given":"Pasquale","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Scientific Directorate of Telese Terme Institute, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-8781","authenticated-orcid":false,"given":"Claudio","family":"Candia","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7389-2033","authenticated-orcid":false,"given":"Elena","family":"Cantone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3692-1384","authenticated-orcid":false,"given":"Aikaterini","family":"Detoraki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Complexities, A.O.U. Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-9921","authenticated-orcid":false,"given":"Mauro","family":"Maniscalco","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"},{"name":"Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0091-6749(83)90518-3","article-title":"Nasal anatomy, physiology, and function","volume":"72","author":"Geurkink","year":"1983","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_2","first-page":"37","article-title":"Nasal cytology","volume":"32","author":"Gelardi","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2301397","DOI":"10.1183\/13993003.01397-2023","article-title":"The airway epithelium: An orchestrator of inflammation, a key structural barrier and a therapeutic target in severe asthma","volume":"63","author":"Russell","year":"2024","journal-title":"Eur. Respir. J."},{"key":"ref_4","first-page":"2837","article-title":"Bronchoalveolar lavage: Are we following ATS guidance?","volume":"56","author":"Allon","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_5","first-page":"2835","article-title":"Bronchial brushing are still usefull in the diagnosis of peripheral lesions?","volume":"56","author":"Torricelli","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1183\/20734735.042912","article-title":"Induced sputum analysis: Step by step","volume":"9","author":"Weiszhar","year":"2013","journal-title":"Breathe"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2500\/ajra.2014.28.4024","article-title":"The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: A 3-year prospective observational study","volume":"28","author":"Vlaminck","year":"2014","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/cea.13207","article-title":"Nasal cytology: Methodology with application to clinical practice and research","volume":"48","author":"Heffler","year":"2018","journal-title":"Clin. Exp. Allergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/alr.22510","article-title":"Sample collection for laboratory-based study of the nasal airway and sinuses: A research compendium","volume":"10","author":"Massey","year":"2020","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4193\/Rhino16.287","article-title":"Nasal cytology in children: Scraping or swabbing?","volume":"55","author":"Pipolo","year":"2017","journal-title":"Rhinology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2500\/105065888781693212","article-title":"Nasal Cytology in Clinical Practice","volume":"2","author":"Meltzer","year":"1988","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1007\/s00405-021-07044-5","article-title":"Diagnostic performance of nasal cytology","volume":"279","author":"Ciofalo","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/1945892418768581","article-title":"Diagnostic Value of Nasal Cytology in Chronic Rhinosinusitis Assessed by a Liquid-based Cytological Technique","volume":"32","author":"She","year":"2018","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2500\/ajr.2007.21.3107","article-title":"Nasal scraping in diagnosing ciliary dyskinesia","volume":"21","author":"Caruso","year":"2007","journal-title":"Am. J. Rhinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1743-422X-3-6","article-title":"Epstein-barr virus induced cellular changes in nasal mucosa","volume":"3","author":"Gelardi","year":"2006","journal-title":"Virol. J."},{"key":"ref_17","unstructured":"(2024, November 26). Progetto ARIA. Allergic Rhinitis and Its Impact on Asthma. Linee-Guida Italiane. Aggiornamento Italia 2014. Modena, m.A.o.h.w.p.-a.i.a.h. Available online: http:\/\/www.progetto-aria.it\/aim.htm."},{"key":"ref_18","first-page":"203","article-title":"The diagnostic value of a cytogram in rhinopathology","volume":"19","author":"Bogaerts","year":"1981","journal-title":"Rhinology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/cea.12730","article-title":"NASAL cytology: Practical aspects and clinical relevance","volume":"46","author":"Gelardi","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1824-7288-38-51","article-title":"Nasal cytology in children: Recent advances","volume":"38","author":"Gelardi","year":"2012","journal-title":"Ital. J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0091-6749(94)90178-3","article-title":"Nasal cytology in patients with allergic rhinitis: Effects of intranasal fluticasone propionate","volume":"94","author":"Meltzer","year":"1994","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/joc.joc_43_22","article-title":"Comparison of Modified Ultrafast Giemsa Stain with the Standard May Grunwald Giemsa Stain in FNAC of Various Organs","volume":"39","author":"Deepthi","year":"2022","journal-title":"J. Cytol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2222.2007.02888.x","article-title":"BSACI guidelines for the management of allergic and non-allergic rhinitis","volume":"38","author":"Scadding","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jaci.2009.06.027","article-title":"Unmet needs in severe chronic upper airway disease (SCUAD)","volume":"124","author":"Bousquet","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_25","first-page":"234","article-title":"\u201cOverlapped\u201d rhinitis: A real trap for rhinoallergologists","volume":"46","author":"Gelardi","year":"2014","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10096-011-1198-x","article-title":"Nasal cytology: The \"infectious spot\", an expression of a morphological-chromatic biofilm","volume":"30","author":"Gelardi","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ACI.0b013e3283423376","article-title":"Bacterial biofilms and the pathophysiology of chronic rhinosinusitis","volume":"11","author":"Kilty","year":"2011","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1128\/JB.01317-06","article-title":"When the party is over: A signal for dispersal of Pseudomonas aeruginosa biofilms","volume":"188","author":"Romeo","year":"2006","journal-title":"J. Bacteriol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Shin, S.H., Ye, M.K., Lee, D.W., and Geum, S.Y. (2023). Immunopathologic Role of Fungi in Chronic Rhinosinusitis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032366"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/allergies2040012","article-title":"Proposal for Structured Histopathology of Nasal Secretions for Endotyping Chronic Rhinosinusitis: An Exploratory Study","volume":"2","author":"Vlaminck","year":"2022","journal-title":"Allergies"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00414-012-0682-x","article-title":"Nasal ciliary motility: A new tool in estimating the time of death","volume":"126","author":"Romanelli","year":"2012","journal-title":"Int. J. Legal Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.chest.2022.11.022","article-title":"Motile Ciliary Disorders of the Nasal Epithelium in Adults With Bronchiectasis","volume":"163","author":"Zhang","year":"2023","journal-title":"Chest"},{"key":"ref_33","unstructured":"Gelardi, M., Giancaspro, R., Cintoli, G., Minafra, S.S., Musto, S., and Cassano, M. (2023). Proposal for a new diagnostic-therapeutic algorithm in chronic rhinosinusitis with nasal polyps. Acta Biomed., 94."},{"key":"ref_34","first-page":"181","article-title":"Nasal-sinus polyposis: Clinical-cytological grading and prognostic index of relapse","volume":"23","author":"Gelardi","year":"2009","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_35","unstructured":"Gelardi, M. (2013). Atlas of Nasal Cytology for the Differential Diagnosis of Nasal Diseases, Edi Ermes. [II ed.]."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1640180","DOI":"10.1155\/2018\/1640180","article-title":"Nasal Cytology: A Comparative Study of Two Different Techniques of Processing-Smeared versus Cytocentrifuged Slides","volume":"2018","author":"Bartoli","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijmedinf.2018.11.010","article-title":"Nasal cytology with deep learning techniques","volume":"122","author":"Dimauro","year":"2019","journal-title":"Int. J. Med. Inform."},{"key":"ref_38","first-page":"8","article-title":"Citologia nasale per l\u2019endotipizzazione della rinite allergica e non allergica e novit\u00e0 sulla lettura automatizzata","volume":"36","author":"Malizia","year":"2022","journal-title":"Ital. J. Pediatr. Allergy Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.anai.2020.03.004","article-title":"A real-world assessment of asthma with chronic rhinosinusitis","volume":"125","author":"Ricciardolo","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gelardi, M., Porro, G., Quaranta, V., Quaranta, N., Cassano, M., Ciprandi, G., and Study Group On, C.I. (2020). Clinical-Cytological-Grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: The relevance in clinical practice. Monaldi Arch. Chest Dis., 90.","DOI":"10.4081\/monaldi.2020.1277"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.14639\/0392-100X-1417","article-title":"Non-surgical management of chronic rhinosinusitis with nasal polyps based on clinical-cytological grading: A precision medicine-based approach","volume":"37","author":"Gelardi","year":"2017","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaip.2020.09.063","article-title":"Chronic Rhinosinusitis with Nasal Polyps and Asthma","volume":"9","author":"Laidlaw","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/alr.20025","article-title":"Atopic profile of patients failing medical therapy for chronic rhinosinusitis","volume":"1","author":"Tan","year":"2011","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4193\/Rhino09.095","article-title":"Comparative clinical and airway inflammatory features of asthmatics with or without polyps","volume":"48","author":"Bilodeau","year":"2010","journal-title":"Rhinology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12948-018-0103-x","article-title":"Comorbidities are associated with different features of severe asthma","volume":"16","author":"Novelli","year":"2018","journal-title":"Clin. Mol. Allergy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.dld.2019.11.008","article-title":"Chronic non-allergic rhinitis with neutrophils is associated with higher acid exposure time: A pH-impedance monitoring study","volume":"52","author":"Mandolesi","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1165\/rcmb.2007-0325OC","article-title":"Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies","volume":"39","author":"McDougall","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mormile, M., Mormile, I., Fuschillo, S., Rossi, F.W., Lamagna, L., Ambrosino, P., de Paulis, A., and Maniscalco, M. (2023). Eosinophilic Airway Diseases: From Pathophysiological Mechanisms to Clinical Practice. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087254"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ambrosino, P., Marcuccio, G., Raffio, G., Formisano, R., Candia, C., Manzo, F., Guerra, G., Lubrano, E., Mancusi, C., and Maniscalco, M. (2024). Endotyping Chronic Respiratory Diseases: T2 Inflammation in the United Airways Model. Life, 14.","DOI":"10.3390\/life14070899"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1164\/rccm.202305-0808OC","article-title":"Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma","volume":"209","author":"Wechsler","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11882-023-01114-w","article-title":"Type 2 Biomarkers for the Indication and Response to Biologics in CRSwNP","volume":"23","author":"Guo","year":"2023","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1378\/chest.13-1703","article-title":"Disability in patients with COPD","volume":"145","author":"Yohannes","year":"2014","journal-title":"Chest"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sanchez-Ramirez, D.C. (2022). Impact of Pulmonary Rehabilitation Services in Patients with Different Lung Diseases. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020407"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.rmed.2004.01.010","article-title":"Upper airway symptoms and quality of life in chronic obstructive pulmonary disease (COPD)","volume":"98","author":"Hurst","year":"2004","journal-title":"Respir. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0954-6111(03)00114-8","article-title":"Relationship between chronic nasal and respiratory symptoms in patients with COPD","volume":"97","author":"Roberts","year":"2003","journal-title":"Respir. Med."},{"key":"ref_56","first-page":"1219","article-title":"Relationships among bacteria, upper airway, lower airway, and systemic inflammation in COPD","volume":"127","author":"Hurst","year":"2005","journal-title":"Chest"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Maniscalco, M., Detoraki, A., Sarnelli, G., Nolano, M., De Paulis, A., Spadaro, G., Cantone, E., and Path-2 Task, F. (2023). A Multidisciplinary Approach for Type 2 Allergic Diseases: What Do Biologics Teach Us?. J. Pers. Med., 13.","DOI":"10.3390\/jpm13060941"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijporl.2019.04.015","article-title":"Nasal cytology in children with primary snoring and obstructive sleep apnoea syndrome","volume":"122","author":"Nosetti","year":"2019","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"959","DOI":"10.5664\/jcsm.6694","article-title":"Allergic and Non-Allergic Rhinitis Are Common in Obstructive Sleep Apnea but Not Associated With Disease Severity","volume":"13","author":"Zheng","year":"2017","journal-title":"J. Clin. Sleep. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1081-1206(10)60138-X","article-title":"Allergic and nonallergic rhinitis: The threat for obstructive sleep apnea","volume":"103","author":"Kalpaklioglu","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s11325-016-1322-3","article-title":"Prevalence of potential nonallergic rhinitis at a community-based sleep medical center","volume":"20","author":"Krakow","year":"2016","journal-title":"Sleep. Breath."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/3\/884\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:38:05Z","timestamp":1759919885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/3\/884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["jcm14030884"],"URL":"https:\/\/doi.org\/10.3390\/jcm14030884","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}