{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:53Z","timestamp":1787028653944,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Synchrony Medical Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Airway clearance techniques are a key element in the daily treatment of people with bronchiectasis. There are several methods and devices to assist in effective airway clearance. We investigated LibAirty, a novel medical device, and compared it with the common practice performed today. Methods: Twenty adults enrolled, and each one had three different treatments in a randomized order: a human respiratory physiotherapist, a High-Frequency Chest Wall Oscillator, and LibAirty with BiPAP. The outcome parameters were mucus weight and a questionnaire. Further studies were performed to investigate LibAirty with hypertonic saline (HS) inhalation and using the device as a standalone. Results: No adverse events were recorded. The sputum amount expectorated in all arms using LibAirty was 14.4 \u00b1 11.1 g with BIPAP, 16.4 \u00b1 7 g with HS, and 11.3 \u00b1 4.1 g for the standalone treatment. For HFCWO, 4.45 \u00b1 3.28 g was obtained, and for CPT, 15.9 \u00b1 11.1 g was obtained. The amount obtained by LibAirty (all arms) was significantly higher than HFCWO. Conclusions: All arms of LibAirty were superior to HFCWO and similar to the human physiotherapist. Further studies should be performed to investigate the long-term effects of LibAirty.<\/jats:p>","DOI":"10.3390\/jcm14030907","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T04:01:39Z","timestamp":1738209699000},"page":"907","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Medical Device for Airway Clearance"],"prefix":"10.3390","volume":"14","author":[{"given":"Nir","family":"Helper","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology and National CF Center, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-9449","authenticated-orcid":false,"given":"Moshe","family":"Ashkenazi","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and National CF Center, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262000, Israel"},{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Sokol","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and National CF Center, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-571X","authenticated-orcid":false,"given":"Adi","family":"Dagan","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and National CF Center, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262000, Israel"},{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Efrati","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and National CF Center, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262000, Israel"},{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00441-016-2562-z","article-title":"Airway mucus, inflammation and remodeling: Emerging links in the pathogenesis of chronic lung diseases","volume":"367","author":"Duerr","year":"2017","journal-title":"Cell Tissue Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/thx.50.2.165","article-title":"Chest physiotherapy in cystic fibrosis: A comparative study of autogenic drainage and the active cycle of breathing techniques with postural drainage","volume":"50","author":"Miller","year":"1995","journal-title":"Thorax"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"106623","DOI":"10.1016\/j.rmed.2021.106623","article-title":"Combined use of rheology and portable low-field NMR in cystic fibrosis patients","volume":"189","author":"Abrami","year":"2021","journal-title":"Respir. 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